DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atet and E23

DIOPT Version :9

Sequence 1:	NP_001097079.1	Gene:	Atet / 33636	FlyBaseID:	FBgn0020762	Length:	832	Species:	Drosophila melanogaster
Sequence 2:	NP_524648.3	Gene:	E23 / 43895	FlyBaseID:	FBgn0020445	Length:	1017	Species:	Drosophila melanogaster

Alignment Length:	882	Identity:	237/882 - (26%)
Similarity:	397/882 - (45%)	Gaps:	141/882 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LQASSVPLVDKCSSHAVILPAAKSPNRVSDSAATTAPNAVLYTSGNMSLSTLSTGSGNPNPNPNA 68
            ||....|.....::.|....:..||...||:.|.|   :|..:..:.|.|..||.|.:.:...:.
  Fly   211 LQIEVEPATSAVAAAAAAAASVASPPATSDATAAT---SVASSDSSASSSASSTSSSSSSSTSSE 272

  Fly    69 STNSRQEPVPLLSQLKLTNDLKQNSHGSQNNLCNGGLGSNNHALAPKVANNSGGS---------- 123
            .|::.|..:|....|..:|                ||.:...::.....:||..|
  Fly   273 FTHTSQTTIPSTDNLTSSN----------------GLANIGKSILVDAKSNSPASLSYHFEKSAA 321

  Fly   124 PNGQKKG---TIALSHLP-----QRPPVDIEFCDISYSVTDSHRRGFKTILKSVSGKFRNGEITA 180
            .|.||:.   .|..||.|     .:|...::....:.:|..:.|:    ||..|||.....|:.|
  Fly   322 ANQQKQHHNINICNSHHPHHHSQNQPQHSLQLTFQNLNVLHNERQ----ILSDVSGFVSPCEVLA 382

  Fly   181 IMGPSGAGKSTLMNILAGYKTAQLSGSVLINSKERNLRRFRKLSCYIMQDDVLIANLTVREAMMV 245
            ||||||:||:||::.|:|.:... ||||.:| :|...:::|:...|::|:::....||:||.::.
  Fly   383 IMGPSGSGKTTLLDCLSGQRHID-SGSVFLN-REPLTKKWRRRIGYVLQEEIFFPQLTLRETVVY 445

  Fly   246 AANLKLGKNMISYAKVVVVEEILETIGLKESVNT-----LTCNLSGGQRKRLSIALELVNNPPVM 305
            .|.|:|.::|....|:..|:.|||.:.|.....|     |...||||::||.:||.||:.||.:|
  Fly   446 TALLRLPESMPRAEKMRQVDHILEALELGCCQQTKFGDYLNRGLSGGEKKRANIACELLTNPLLM 510

  Fly   306 FFDEPTSGLDSSTCFQLISLLRSLAR-GGRTIVCTIHQPSARLFEKFDHLYLLAQGQCVYEGRVK 369
            ..|||||||||.:...|:.:|:..|: ..:|||.::||||:::|..||.|.||.||:..|.|.|:
  Fly   511 LLDEPTSGLDSHSAISLMKVLKRYAQLEQKTIVISVHQPSSQMFHMFDKLLLLHQGRTAYFGDVQ 575

  Fly   370 GLVPYLSSLGYECPSYHNPADYVLEVASGEYGDAVPKLVDAVKSGACKKYAHKDYVLTLAQKGC- 433
            .:..:...:|.....::||||:|||... .:.|...||..|.|.      :|.:|:    .:.|
  Fly   576 NIYRHFEDIGVTIKPHYNPADFVLEQLK-SHPDIREKLFIAAKE------SHGNYL----NRNCI 629

  Fly   434 ----NNDIIKGSGSGAENAMAILTLEDEKPPLEDRQLEPSIPVDD--------PAELKPPKLETQ 486
                :|.:......|.:.|.:||                   :||        .:.....:.|..
  Fly   630 TSSHHNQVSVSGAKGKKQADSIL-------------------IDDIINNYYNQRSNRHHHQYENL 675

  Fly   487 QSQNSDCSV-------VNMPTNAVDDSCSFSSSKGTQNAVGGSGSG-GPSAVVGCMTSLLDSHES 543
            ...::.|.|       .::...|.|...:|||...:......:||| |.||....::
  Fly   676 HHTSNGCRVEEDEEAAQHLVWCAADSQSNFSSCASSDCHSYSAGSGPGHSADDDWLS-------- 732

  Fly   544 VVTLPNKTGFPTSGWTQFWILLKRSFRTILRDKMLTHMRLFSHVIVGAIIGMIYYDVGNEASKIM 608
                     :|||..|||.:|..|:||. .:.:||:.:..|..:.:..:.|.|::.:......:.
  Fly   733 ---------YPTSFHTQFCVLSSRNFRE-AKPRMLSKLNWFQTIGLALMAGAIWFQLPRTEEFLH 787

  Fly   609 SNAGCIFFVSLFTTFTAMMPTILTFPTEMSVFVREHLNYWYSLKAFYFAKTIADMPFQIVFSSVY 673
            ...|.:||...:....|:...:.:||:|..|..:|..:..|.|.|:|.||..|::|..|...:||
  Fly   788 DLQGWMFFSQTYWMLFALFGALNSFPSEREVVSKERRSGAYRLSAYYLAKMCAELPLVITLPTVY 852

  Fly   674 VLVVYYLTSQPM----ELERVSMFVLICVLNSLVAQSLGLLIGA-GMNIETGVFLGPVTTIPTIL 733
            :::.|     ||    .|:...:.::..::|::||||:|..||| .|::...:.|..:.|:.|.|
  Fly   853 LMISY-----PMLGCTSLKLFFLMLIFLLINTIVAQSVGFFIGACCMDMNVSITLSALYTLATQL 912

  Fly   734 FSGFFVNFDTIPGYLQWVTYVSYVRYGF---------EGAMVAIYGMDRAKMQCNQMYCHYRVPK 789
            |.|:..:  .||..|.|:.|.|.:.|.:         |||.:.. |...:...|.|....: :|.
  Fly   913 FGGYLSS--RIPEGLSWIRYTSMIHYAYQNMQILEFREGAAIGC-GSPSSYEICKQQSTEF-IPY 973

  Fly   790 KFLEEMSMDNALFWVDAVALIGIFFALRIIAYFVLRW 826
            :.:.:.....:..|::.:.|:..|...|.:.|.|||:
  Fly   974 EEILKAQNSTSPLWLNTLILMMFFLVFRCLGYAVLRF 1010

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atet	NP_001097079.1	3a01204	137..825	CDD:273361	203/733 (28%)
		ABCG_EPDR	142..366	CDD:213180	87/229 (38%)
		ABC2_membrane	564..767	CDD:279410	59/216 (27%)
E23	NP_524648.3	ABCG_EPDR	350..572	CDD:213180	87/227 (38%)
		3a01204	363..1009	CDD:273361	200/708 (28%)
		ABC2_membrane	744..943	CDD:279410	56/206 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	79	1.000	Domainoid score	I2350
eggNOG	1	0.900	-	-		E2759_KOG0061
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	1	1.000	-	-		otm46658
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	1	1.100	-	-	P	PTHR48041
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
	8	7.810