DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atet and Abcg2

DIOPT Version :9

Sequence 1:	NP_001097079.1	Gene:	Atet / 33636	FlyBaseID:	FBgn0020762	Length:	832	Species:	Drosophila melanogaster
Sequence 2:	NP_852046.1	Gene:	Abcg2 / 312382	RGDID:	631345	Length:	657	Species:	Rattus norvegicus

Alignment Length:	758	Identity:	212/758 - (27%)
Similarity:	353/758 - (46%)	Gaps:	151/758 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 SNNHALAPKVANNSGGSPNGQKKG--TIALSHLPQRPPVDIEFCDISYSVTDSHRRGF------- 162
            ||:|.|.|....|..|.|....:|  |:|...:       :.|..|:|.|  ..:.||
  Rat     4 SNDHVLVPMSQRNKNGLPGMSSRGARTLAEGDV-------LSFHHITYRV--KVKSGFLVRKTAE 59

  Fly   163 KTILKSVSGKFRNGEITAIMGPSGAGKSTLMNILAGYKTAQ-LSGSVLINSKERNLRRFRKLSCY 226
            |.||..::|..:.| :.||:||:|.|||:|:::||..|..: |||.||||...:. ..|:..|.|
  Rat    60 KEILSDINGIMKPG-LNAILGPTGGGKSSLLDVLAARKDPRGLSGDVLINGAPQP-ANFKCSSGY 122

  Fly   227 IMQDDVLIANLTVREAMMVAANLKLGKNMISYAKVVVVEEILETIGLKESVNT-----LTCNLSG 286
            ::||||::..|||||.:..:|.|:|.|.|.::.|...:..|::.:||.:..::     .|..:||
  Rat   123 VVQDDVVMGTLTVRENLQFSAALRLPKAMKTHEKNERINTIIKELGLDKVADSKVGTQFTRGISG 187

  Fly   287 GQRKRLSIALELVNNPPVMFFDEPTSGLDSSTCFQLISLLRSLARGGRTIVCTIHQPSARLFEKF 351
            |:|||.||.:||:.:|.::|.||||:||||||...::.||:.:::.||||:.:||||...:|:.|
  Rat   188 GERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLF 252

  Fly   352 DHLYLLAQGQCVYEGRVKGLVPYLSSLGYECPSYHNPADYVLEVASGEYGDAVPKLVDAVKSGAC 416
            |.|.|||.|:.::.|..:..:.|.:|.||.|..|:||||:.|:|.:|:
  Rat   253 DSLTLLASGKLMFHGPAQKALEYFASAGYHCEPYNNPADFFLDVINGD----------------- 300

  Fly   417 KKYAHKDYVLTLAQKGCNNDIIKGSGSGAENAMAILTLEDEKPPLEDRQLEPSIPVDDPAELKPP 481
                                           :.|::....|    :|.:...:   ::|::.:.|
  Rat   301 -------------------------------SSAVMLNRGE----QDHEANKT---EEPSKREKP 327

  Fly   482 KLETQQSQNSDCSVVNMPTNAVDDSCSFSSSKGTQNAVGGSGSGGPSAVVGCMTSLLDSHESVVT 546
            .:|.......: |.:...|.|..|....:..|           .|.||.          .|.|
  Rat   328 IIENLAEFYIN-STIYGETKAELDQLPVAQKK-----------KGSSAF----------REPV-- 368

  Fly   547 LPNKTGFPTSGWTQFWILLKRSFRTILRDKMLTHMRLFSHVIVGAIIGMIYYDVGNEASKIMSNA 611
                  :.||...|...:.:|||:.:|.:...:..:|...||:|.|||.:|:.:.|:.:.:.:.|
  Rat   369 ------YVTSFCHQLRWIARRSFKNLLGNPQASVAQLIVTVILGLIIGALYFGLKNDPTGMQNRA 427

  Fly   612 GCIFFVSLFTTFTAMMPTILTFPTEMSVFVREHLNYWYSLKAFYFAKTIAD-MPFQIVFSSVYVL 675
            |..||::....||::....| |..|..:|:.|:::.:|.:.:::|.|.::| :|.:.:.|.:|..
  Rat   428 GVFFFLTTNQCFTSVSAVEL-FVVEKKLFIHEYISGYYRVSSYFFGKLVSDLLPMRFLPSVIYTC 491

  Fly   676 VVYYLTSQPMELER--VSMFVLICVLNSLVAQSLGLLIGAGMN-IETGVFLGPVTTIPTILFSGF 737
            ::|::......:|.  :.||.||.|  :..|.|:.|.|.||.: :.....|..::.:..:||||.
  Rat   492 LLYFMLGLKRTVEAFFIMMFTLIMV--AYTASSMALAIAAGQSVVSVATLLMTISFVFMMLFSGL 554

  Fly   738 FVNFDTIPGYLQWVTYVSYVRYGFEGAMVAIYGMDRAKMQCN----QMYC-------------HY 785
            .||..||..:|.|:.|.|..||||            ..:|.|    |.:|             .|
  Rat   555 LVNLRTIGPWLSWLQYFSIPRYGF------------TALQHNEFLGQEFCPGLNVTMNSTCVNSY 607

  Fly   786 RV--PKKFLEEMSMDNALF--WVDAVALIGIFFALRIIAYFVL 824
            .:  ...:|....:|.:.:  |.:.|||..:......|||..|
  Rat   608 TICTGNDYLINQGIDLSPWGLWRNHVALACMIIIFLTIAYLKL 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atet	NP_001097079.1	3a01204	137..825	CDD:273361	201/726 (28%)
		ABCG_EPDR	142..366	CDD:213180	92/236 (39%)
		ABC2_membrane	564..767	CDD:279410	61/206 (30%)
Abcg2	NP_852046.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25		8/20 (40%)
Abcg2	NP_852046.1	3a01204	46..651	CDD:273361	198/709 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335095
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.640