DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atet and Abca12

DIOPT Version :9

Sequence 1:	NP_001097079.1	Gene:	Atet / 33636	FlyBaseID:	FBgn0020762	Length:	832	Species:	Drosophila melanogaster
Sequence 2:	XP_237242.6	Gene:	Abca12 / 301482	RGDID:	1304586	Length:	2595	Species:	Rattus norvegicus

Alignment Length:	877	Identity:	185/877 - (21%)
Similarity:	309/877 - (35%)	Gaps:	261/877 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 LKLTNDLKQNSHGSQNNLCNGGLGSNNHALAPKVANNSGGSPNGQKKGTIALSHLPQRPPVDIEF 147
            |..||.:.|:::.|.|.            .:|..|..|...|.                |.|::.
  Rat  1308 LMFTNIMMQSTNPSANK------------TSPDCAFPSNIEPE----------------PKDLQV 1344

  Fly   148 CDISYSVTDSHRRGFKTILKSVSGKFRNGEITAIMGPSGAGKSTLMNILAGYKTAQLSGSVLINS 212
            ....:.||.|:  |.||.:.:::..|..|.||:::||:||||:|.:::|.|...| .:|::.:..
  Rat  1345 GVALHGVTKSY--GSKTAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGA-TAGTIFVYG 1406

  Fly   213 KE--RNLRRFRKLSCYIMQDDVLIANLTVREAMMVAANLKLGKNMISYAKVVVVEEILETI---G 272
            |:  .:|...||.....||.|||.:.||.:|.:::..::|:.    .:.|..:.||:..|:   |
  Rat  1407 KDIKTDLNTVRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVP----HWTKKQLHEEVKRTLKDTG 1467

  Fly   273 LKESVNTLTCNLSGGQRKRLSIALELVNNPPVMFFDEPTSGLDSSTCFQLISLLRSLARGGRTIV 337
            |....:.....||||.:::|||::.|:....|:..|||::|:|..:...:..:: |..:..|||:
  Rat  1468 LYSHRHKRVGTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVI-SKNKTARTII 1531

  Fly   338 -CTIHQPSARLFEKFDHLYLLAQGQCVYEGRVKGLVPYLSSLGYEC---PSYHNPADYVLEVASG 398
             .|.|...|.:..  |.:..|.||                  |..|   |.|...|
  Rat  1532 LSTHHLDEAEVLS--DRIAFLEQG------------------GLRCCGSPFYLKEA--------- 1567

  Fly   399 EYGDAVPKLVDAVKSGACKKYAHKDYVLTLAQKGCNN-DIIKGSGSGAENAMAILTLEDEKPPLE 462
             :||.                    |.|||.:|...| |......:.|..||    ::...|
  Rat  1568 -FGDG--------------------YHLTLTKKKSPNLDTNAICDTVAVTAM----IQSHLP--- 1604

  Fly   463 DRQLEPSIPVDDPAEL---KPP---------------------KLETQQSQNSDCSVVNMPTNAV 503
                |..:..|...||   .||                     ||.......||.:|..:..|..
  Rat  1605 ----EAYLKEDIGGELVYVLPPFSTKVSGAYLSLLRALDKGMGKLNIGCYGISDTTVEEVFLNLT 1665

  Fly   504 DDS--C-SFSSSKGTQNAVG---GSGSGGPSAVVGCMTSLLDSHESVVTLPNK-TGFPTSGWTQF 561
            .||  | :.|....||..||   .:|:..|..:....::..|..:.|:|...: .||........
  Rat  1666 KDSQKCGNMSLEHLTQRKVGNPSANGTSTPDDLSVSSSNFTDRDDKVLTRSERLDGFGLLLKKIM 1730

  Fly   562 WILLKRSFRTILRDKMLTHMRLFSHVIVGAIIGM-IYYDVGNEASKIM-------SNAGCIFFVS 618
            .||:||...|....|.|....:...|.|...:|: ...|..|...:::       ::....|:.:
  Rat  1731 AILIKRFHHTRRNWKGLIAQVVLPIVFVATAMGLGTLRDSSNSYPELLISPSIYGNSEQTAFYAN 1795

  Fly   619 LFTTFTAMMPTILTFP---------TEMSVFVREHLNYW-------------------YSLKAFY 655
            ...:..|::..:..||         ::.....:::|..|                   .....|.
  Rat  1796 FDPSTNALVSALWNFPGIDNVCLNTSDSQCLKKDNLGKWNTSGEAIDNFGVCSCSDNVQECPKFN 1860

  Fly   656 FAKTIADMPFQIVFSSVYVLVVYYLTSQPMELERVSMFVLICVLNSLVAQ-----SLGLLIGAGM 715
            ::.     |.:..:||   .|:|.||.:.||      ..||...|..|.:     |.|:.:...:
  Rat  1861 YSP-----PHRRTYSS---QVIYNLTGKHME------NYLISTANHFVQKRYGGWSFGMKLTNDL 1911

  Fly   716 NIETGVFLGPVTTIPTILFSGFFVN------------FDTIPGYLQ-------WVTYVSY--VRY 759
            ..:       ||.:|        ||            :.::|.||.       .|....|  .|:
  Rat  1912 RFD-------VTAVP--------VNRTLAKVWYDPEGYHSLPAYLNSLNNFLLRVNMSEYDAARH 1961

  Fly   760 G-------FEGA--------------MVAI-----YGMDRAKMQCNQMYCHYRVPKKFLEEMSMD 798
            |       :.|.              :||:     |.:..|......:..|....|:......:.
  Rat  1962 GIIMYSHPYPGVQDQEQATISSLIDILVALSILMGYSVTTASFVTYIVREHQTKAKQLQHISGIG 2026

  Fly   799 NALFWV-----DAV-ALIGIFFALRIIAYFVL 824
            ...:||     |.| .|:.:.|::.:||.|.|
  Rat  2027 VTCYWVTNFIYDMVFYLVPVAFSIGVIAIFKL 2058

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atet	NP_001097079.1	3a01204	137..825	CDD:273361	175/823 (21%)
		ABCG_EPDR	142..366	CDD:213180	67/229 (29%)
		ABC2_membrane	564..767	CDD:279410	46/285 (16%)
Abca12	XP_237242.6	ABC2_membrane_3	<1006..1267	CDD:289468
		NosY	<1108..1269	CDD:224196
		ZnuC	1346..1570	CDD:224046	70/261 (27%)
		ABC_subfamily_A	1350..1565	CDD:213230	69/242 (29%)
		ABC2_membrane_3	<1913..2174	CDD:289468	29/161 (18%)
		CcmA	2253..2567	CDD:224054
		ABC_subfamily_A	2254..2477	CDD:213230
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000