DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atet and Abcg4

DIOPT Version :9

Sequence 1:	NP_001097079.1	Gene:	Atet / 33636	FlyBaseID:	FBgn0020762	Length:	832	Species:	Drosophila melanogaster
Sequence 2:	NP_001100286.2	Gene:	Abcg4 / 300664	RGDID:	1305840	Length:	646	Species:	Rattus norvegicus

Alignment Length:	745	Identity:	349/745 - (46%)
Similarity:	464/745 - (62%)	Gaps:	132/745 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 GLGSNNHALAPKVANNSGGSP---------------NGQKKGTIALSHLPQRPPVDIEFCDISYS 153
            |.|....|:|..||...|..|               ..|:     .||||:|..|||||.::|||
  Rat    10 GCGLGPGAVAMAVALEDGAEPPVLTTHLKKVENHITEAQR-----FSHLPKRSAVDIEFVELSYS 69

  Fly   154 VTDS---HRRGFKTILKSVSGKFRNGEITAIMGPSGAGKSTLMNILAGYKTAQLSGSVLINSKER 215
            |.:.   .:||:||:||.:||||...|:..|||||||||||.|||||||:.:.:.|.:|:|.:.|
  Rat    70 VREGPCWRKRGYKTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGRPR 134

  Fly   216 NLRRFRKLSCYIMQDDVLIANLTVREAMMVAANLKLGKNMISYAKVVVVEEILETIGLKESVNTL 280
            :||.|||:||||||||:|:.:|||.|||||:|||||.:.  ...|..:|.|||..:||....:|.
  Rat   135 DLRTFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEK--QEVKKELVTEILTALGLMSCSHTR 197

  Fly   281 TCNLSGGQRKRLSIALELVNNPPVMFFDEPTSGLDSSTCFQLISLLRSLARGGRTIVCTIHQPSA 345
            |..|||||||||:|||||||||||||||||||||||::|||::||::|||.||||::||||||||
  Rat   198 TALLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAHGGRTVICTIHQPSA 262

  Fly   346 RLFEKFDHLYLLAQGQCVYEGRVKGLVPYLSSLGYECPSYHNPADYVLEVASGEYGDAVPKLVDA 410
            :|||.||.||:|:||||:::|.|..|:|||..||..||:||||||:::|||||||||..|.|..|
  Rat   263 KLFEMFDKLYILSQGQCIFKGVVTNLIPYLKGLGLHCPTYHNPADFIIEVASGEYGDLNPMLFRA 327

  Fly   411 VKSGACKKYAHKDYVLTLAQKGCNNDIIKGSGSGAENAMAILTLEDEKPPLEDRQLEPSIPVDDP 475
            |::|.|          |:|:|         ..|..:|                     .:|...|
  Rat   328 VQNGLC----------TMAEK---------KSSPEKN---------------------EVPAHCP 352

  Fly   476 AELKPPKLETQQSQNSDCSVVNMPTNAVDDSCSFSSSKGTQNAVGGSGSGGPSAVVGCMTSLLDS 540
            .  .||:|:.                                                    ::|
  Rat   353 T--CPPELDP----------------------------------------------------IES 363

  Fly   541 HESVVTLPNKTGFPTSGWTQFWILLKRSFRTILRDKMLTHMRLFSHVIVGAIIGMIYYDVGNEAS 605
            |.          |.||..|||.||.:|:|.:||||.:|||:|..|||::|.:||::|..:|::||
  Rat   364 HT----------FATSTLTQFCILFRRTFLSILRDTVLTHLRFMSHVLIGVLIGLLYLHIGDDAS 418

  Fly   606 KIMSNAGCIFFVSLFTTFTAMMPTILTFPTEMSVFVREHLNYWYSLKAFYFAKTIADMPFQIVFS 670
            |:.:|.|.:||..||..|.|:|||:||||.||:||:||||||||||||:|.|||:||:|||:|..
  Rat   419 KVFNNTGFLFFSMLFLMFAALMPTVLTFPLEMAVFMREHLNYWYSLKAYYLAKTMADVPFQVVCP 483

  Fly   671 SVYVLVVYYLTSQPMELERVSMFVLICVLNSLVAQSLGLLIG-AGMNIETGVFLGPVTTIPTILF 734
            .||..:||::|.||.|..|..:|..:.:..:||||||||||| |..:::...|:||||.||.:||
  Rat   484 VVYCSIVYWMTGQPAETSRFLLFSALSIATALVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLF 548

  Fly   735 SGFFVNFDTIPGYLQWVTYVSYVRYGFEGAMVAIYGMDRAKMQCNQMYCHYRVPKKFLEEMSMDN 799
            |||||:|.|||.||||.:|:|||||||||.::.||||:|..:.|.:.:|.:|.|:..|.|:.::.
  Rat   549 SGFFVSFKTIPTYLQWSSYLSYVRYGFEGLILTIYGMERGHLTCLEDHCPFRDPQIILHELDVEE 613

  Fly   800 ALFWVDAVALIGIFF-ALRIIAYFVLRWKL 828
            |..::|.:.| |||| |||::||.|||:::
  Rat   614 AKLYMDFLVL-GIFFLALRLLAYLVLRYRV 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atet	NP_001097079.1	3a01204	137..825	CDD:273361	336/692 (49%)
		ABCG_EPDR	142..366	CDD:213180	142/226 (63%)
		ABC2_membrane	564..767	CDD:279410	117/203 (58%)
Abcg4	NP_001100286.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335089
Domainoid	1	1.000	272	1.000	Domainoid score	I1735
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H75179
Inparanoid	1	1.050	695	1.000	Inparanoid score	I656
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177791at33208
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	1	1.100	-	-	LDO	PTHR48041
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760