DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atet and Abcg5

DIOPT Version :9

Sequence 1:	NP_001097079.1	Gene:	Atet / 33636	FlyBaseID:	FBgn0020762	Length:	832	Species:	Drosophila melanogaster
Sequence 2:	NP_114090.1	Gene:	Abcg5 / 27409	MGIID:	1351659	Length:	652	Species:	Mus musculus

Alignment Length:	763	Identity:	181/763 - (23%)
Similarity:	315/763 - (41%)	Gaps:	174/763 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 SPNGQKKGTI---ALSHLPQRPPVDIE------FCDISYSVTD----------SHRRGFKTILKS 168
            ||.|.:...|   :||.|.|......|      ...:||||::          ..::..:.|||.
Mouse     8 SPEGARGPHINRGSLSSLEQGSVTGTEARHSLGVLHVSYSVSNRVGPWWNIKSCQQKWDRQILKD 72

  Fly   169 VSGKFRNGEITAIMGPSGAGKSTLMNILAG--YKTAQLSGSVLINSKERNLRRFRKLSCYIMQDD 231
            ||....:|:|..|:|.||:||:||::.::|  .:|..|.|.|.:|..|....:|:....|::|.|
Mouse    73 VSLYIESGQIMCILGSSGSGKTTLLDAISGRLRRTGTLEGEVFVNGCELRRDQFQDCFSYVLQSD 137

  Fly   232 VLIANLTVREAMMVAANLKLGKNMIS-YAKVVVVEEILETIGLKESVNTLTCN-----LSGGQRK 290
            |.:::|||||.:...|.|.|.::... |.|  .||.::..:.|....:.:..:     :|.|:|:
Mouse   138 VFLSSLTVRETLRYTAMLALCRSSADFYNK--KVEAVMTELSLSHVADQMIGSYNFGGISSGERR 200

  Fly   291 RLSIALELVNNPPVMFFDEPTSGLDSSTCFQLISLLRSLARGGRTIVCTIHQPSARLFEKFDHLY 355
            |:|||.:|:.:|.||..||||:|||..|..|::.||..|||..|.::.|||||.:.||:.||.:.
Mouse   201 RVSIAAQLLQDPKVMMLDEPTTGLDCMTANQIVLLLAELARRDRIVIVTIHQPRSELFQHFDKIA 265

  Fly   356 LLAQGQCVYEGRVKGLVPYLSSLGYECPSYHNPADYVLEVASGEYGDAVPKLVDAVKSGACKKYA 420
            :|..|:.|:.|..:.::.:.::.||.||.:.||.|:.:::.|          ||.
Mouse   266 ILTYGELVFCGTPEEMLGFFNNCGYPCPEHSNPFDFYMDLTS----------VDT---------- 310

  Fly   421 HKDYVLTLAQKGCNNDIIKGSGSGAENAMAILTLEDEKPPLEDRQLEPSIPVDDPAELKPPKLET 485
                                                     :.|:.|               :||
Mouse   311 -----------------------------------------QSRERE---------------IET 319

  Fly   486 QQSQNSDCSVVNMPTNAVDDSCSFSSSKGTQNAVGGSGSGGPSAVVGCMTSLLDSHE------SV 544
            .:.       |.|.      .|:|..|                   .....:|::.|      ::
Mouse   320 YKR-------VQML------ECAFKES-------------------DIYHKILENIERARYLKTL 352

  Fly   545 VTLPNKTGFPTSGWTQFWILLKRSFRTILRDKMLTHMRLFSHVIVGAIIGMIYYDVGNEASK--I 607
            .|:|.||..|...:.:..:||:|..|.::|:|....|||..::|:|..:......|.|...|  :
Mouse   353 PTVPFKTKDPPGMFGKLGVLLRRVTRNLMRNKQAVIMRLVQNLIMGLFLIFYLLRVQNNTLKGAV 417

  Fly   608 MSNAGCIFFVSLFTTFTAMMPTILTFPTEMSVFVREHLNYWYSLKAFYFAKTIADMPFQIVFSSV 672
            ....|.::.:...|.:|.|:..:..||...:|..:|..:..|.......|..:..:||.::.:.:
Mouse   418 QDRVGLLYQLVGATPYTGMLNAVNLFPMLRAVSDQESQDGLYHKWQMLLAYVLHVLPFSVIATVI 482

  Fly   673 YVLVVYYLTSQPMELERVSMFVLICVLNSLVAQSLGLLIGAGMNIETGVFLGP--VTTIPTILF- 734
            :..|.|:......|:.|...|....:...|:.:.|.|::       .|:...|  |.:|..:|.
Mouse   483 FSSVCYWTLGLYPEVARFGYFSAALLAPHLIGEFLTLVL-------LGIVQNPNIVNSIVALLSI 540

  Fly   735 ------SGFFVNFDTIPGYLQWVTYVSYVRYGFEGAMV-AIYGMDRAKMQC--------NQMYCH 784
                  |||..|...:|..|:.:.|.::.:|..|..:| ..||::   ..|        |...|.
Mouse   541 SGLLIGSGFIRNIQEMPIPLKILGYFTFQKYCCEILVVNEFYGLN---FTCGGSNTSMLNHPMCA 602

  Fly   785 YRVPKKFLEEMSMD-NALFWVDAVALIGIFFALRIIAYFVLRWKLHMI 831
            .....:|:|:.... .:.|..:.:.|.|...||.|:...:.:.:.::|
Mouse   603 ITQGVQFIEKTCPGATSRFTANFLILYGFIPALVILGIVIFKVRDYLI 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atet	NP_001097079.1	3a01204	137..825	CDD:273361	174/738 (24%)
		ABCG_EPDR	142..366	CDD:213180	83/247 (34%)
		ABC2_membrane	564..767	CDD:279410	49/214 (23%)
Abcg5	NP_114090.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25		6/16 (38%)
		ABCG_White	50..276	CDD:213201	78/227 (34%)
		3a01204	61..646	CDD:273361	167/704 (24%)
		ABC2_membrane	372..579	CDD:279410	48/213 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810