DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atet and bfr1

DIOPT Version :9

Sequence 1:	NP_001097079.1	Gene:	Atet / 33636	FlyBaseID:	FBgn0020762	Length:	832	Species:	Drosophila melanogaster
Sequence 2:	NP_587932.3	Gene:	bfr1 / 2539195	PomBaseID:	SPCC18B5.01c	Length:	1530	Species:	Schizosaccharomyces pombe

Alignment Length:	808	Identity:	192/808 - (23%)
Similarity:	326/808 - (40%)	Gaps:	221/808 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 APKVANNSGGSP----NGQ--KKGTIALSHLPQRPPVDIEF------------CDISY--SVTDS 157
            |.|.|.|.||.|    .||  :.|.:..........::.|:            .:::|  .:...
pombe   832 AVKAAVNEGGKPLDLETGQDTQGGDVVKESPDNEEELNKEYEGIEKGHDIFSWRNLNYDIQIKGE 896

  Fly   158 HRRGFKTILKSVSGKFRNGEITAIMGPSGAGKSTLMNILA-GYKTAQLSGSVLINSKERNLRRFR 221
            |||    :|..|.|....|::||:||.|||||:||:|:|| ...|..::|.:|:|.:..: ..|:
pombe   897 HRR----LLNGVQGFVVPGKLTALMGESGAGKTTLLNVLAQRVDTGVVTGDMLVNGRGLD-STFQ 956

  Fly   222 KLSCYIMQDDVLIANLTVREAMMVAANLKLGKNMISYAKVVVVEEILETIGLKE----SVNTLTC 282
            :.:.|:.|.||.|...|||||:..:|.|:...::....|...||.:::.:.::.    .:.|...
pombe   957 RRTGYVQQQDVHIGESTVREALRFSAALRQPASVPLSEKYEYVESVIKLLEMESYAEAIIGTPGS 1021

  Fly   283 NLSGGQRKRLSIALELVNNPP-VMFFDEPTSGLDSSTCFQLISLLRSLARGGRTIVCTIHQPSAR 346
            .|:..||||.:|.:||...|. ::|.|||||||||.:.:.::..||.||..|:.|:||||||||.
pombe  1022 GLNVEQRKRATIGVELAAKPALLLFLDEPTSGLDSQSAWSIVCFLRKLADAGQAILCTIHQPSAV 1086

  Fly   347 LFEKFDHLYLLAQ-GQCVYEGRV----KGLVPYLSSLG-YECPSYHNPADYVLEVASGEYGDAVP 405
            ||::||.|.||.: |:.||.|.:    |.|:.|..|.| ..||...|||:|:|
pombe  1087 LFDQFDRLLLLQKGGKTVYFGDIGEHSKTLLNYFESHGAVHCPDDGNPAEYIL------------ 1139

  Fly   406 KLVDAVKSGACKKYAHKDYVLTLAQKGCNNDIIKGSGSGAENAMAILTLEDEKPPLEDRQLEPSI 470
               |.:.:||... .::|:     .:..||.
pombe  1140 ---DVIGAGATAT-TNRDW-----HEVWNNS---------------------------------- 1161

  Fly   471 PVDDPAELKPPKLETQQSQNSDCSVVNMPTNAVDDSCSFSSSKGTQNAVGGSGSGGPSAVVGCMT 535
                         |.:::.:::...:|         .|||:|:..:
pombe  1162 -------------EERKAISAELDKIN---------ASFSNSEDKK------------------- 1185

  Fly   536 SLLDSHESVVTLPNKTGFPTSGWTQFWILLKRSFRTILRDKMLTHMRLFSHVIVGAIIGMIYYDV 600
            :|.....|...:|.        |.|..:::.|:|::..|:..:...:|...:..|..||..:|:.
pombe  1186 TLSKEDRSTYAMPL--------WFQVKMVMTRNFQSYWREPSILMSKLALDIFAGLFIGFTFYNQ 1242

  Fly   601 GNEASKIMSNAGCIFFVSLFTTFTAMMPTILTFP---------TEM-SVF-VREHLNYWYSLKAF 654
            |.....|.:        .||..|   |.|:|..|         .|: :|| |||..:..||..||
pombe  1243 GLGVQNIQN--------KLFAVF---MATVLAVPLINGLQPKFIELRNVFEVREKPSNIYSWVAF 1296

  Fly   655 YFAKTIADMPFQIVFSSVYVLVVYYLTSQPMEL--------ERVSMFVLICVLNSLVAQSLGLLI 711
            .|:..|.::||.:||.:::.|..:|    |::.        ::.....|:.:...:...:.|..:
pombe  1297 VFSAIIVEIPFNLVFGTLFFLCWFY----PIKFYKHIHHPGDKTGYAWLLYMFFQMYFSTFGQAV 1357

  Fly   712 GAGM-NIETGVFLGPVTTIPTILFSGFFVNFDTIPGYLQWVTYVSYVRYGFEGAMV-AIYGM--- 771
            .:.. |.:|...:..:.....|.|:|.......:.|:..|:..::...|..||.:. .::|:
pombe  1358 ASACPNAQTASVVNSLLFTFVITFNGVLQPNSNLVGFWHWMHSLTPFTYLIEGLLSDLVHGLPVE 1422

  Fly   772 ------------------------------------DRAKMQCNQMYCHYRVPKKFLEEMSMDNA 800
                                                ..|...|:  ||.|:...:|||..||...
pombe  1423 CKSHEMLTINPPSGQTCGEYMSAFLTNNTAAGNLLNPNATTSCS--YCPYQTADQFLERFSMRYT 1485

  Fly   801 LFWVDAVALIG-IFFAL--RIIAYFVLR 825
            ..|.:....:| :||.:  .::.::|.|
pombe  1486 HRWRNLGIFVGYVFFNIFAVLLLFYVFR 1513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atet	NP_001097079.1	3a01204	137..825	CDD:273361	181/776 (23%)
		ABCG_EPDR	142..366	CDD:213180	87/244 (36%)
		ABC2_membrane	564..767	CDD:279410	48/223 (22%)
bfr1	NP_587932.3	ABC_trans_N	<102..160	CDD:291196
		3a01205	108..1516	CDD:273362	192/808 (24%)
		ABCG_PDR_domain1	166..392	CDD:213200
		ABC2_membrane	526..729	CDD:279410
		PDR_CDR	741..835	CDD:283960	1/2 (50%)
		ABCG_PDR_domain2	879..1107	CDD:213199	86/232 (37%)
		ABC2_membrane	1206..1413	CDD:279410	48/221 (22%)
		PDR_CDR	<1474..>1508	CDD:283960	9/33 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	79	1.000	Domainoid score	I2350
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
TreeFam	0	0.000	Not matched by this tool.
	3	2.900