DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atet and Abcg4

DIOPT Version :9

Sequence 1:	NP_001097079.1	Gene:	Atet / 33636	FlyBaseID:	FBgn0020762	Length:	832	Species:	Drosophila melanogaster
Sequence 2:	NP_620405.3	Gene:	Abcg4 / 192663	MGIID:	1890594	Length:	646	Species:	Mus musculus

Alignment Length:	745	Identity:	347/745 - (46%)
Similarity:	460/745 - (61%)	Gaps:	132/745 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 GLGSNNHALAPKVANNSGGSP---------------NGQKKGTIALSHLPQRPPVDIEFCDISYS 153
            |.|....|:|..|....|..|               ..|:     .||||:|..|||||.::|||
Mouse    10 GCGLGPGAVAMAVTLEDGAEPPVLTTHLKKVENHITEAQR-----FSHLPKRSAVDIEFVELSYS 69

  Fly   154 VTDS---HRRGFKTILKSVSGKFRNGEITAIMGPSGAGKSTLMNILAGYKTAQLSGSVLINSKER 215
            |.:.   .:||:||:||.:||||...|:..|||||||||||.|||||||:.:.:.|.:|:|.:.|
Mouse    70 VREGPCWRKRGYKTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGRPR 134

  Fly   216 NLRRFRKLSCYIMQDDVLIANLTVREAMMVAANLKLGKNMISYAKVVVVEEILETIGLKESVNTL 280
            .||.|||:||||||||:|:.:|||.|||||:|||||.:.  ...|..:|.|||..:||....:|.
Mouse   135 ELRTFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEK--QEVKKELVTEILTALGLMSCSHTR 197

  Fly   281 TCNLSGGQRKRLSIALELVNNPPVMFFDEPTSGLDSSTCFQLISLLRSLARGGRTIVCTIHQPSA 345
            |..|||||||||:|||||||||||||||||||||||::|||::||::|||.||||::||||||||
Mouse   198 TALLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAHGGRTVICTIHQPSA 262

  Fly   346 RLFEKFDHLYLLAQGQCVYEGRVKGLVPYLSSLGYECPSYHNPADYVLEVASGEYGDAVPKLVDA 410
            :|||.||.||:|:||||:::|.|..|:|||..||..||:||||||:::|||||||||..|.|..|
Mouse   263 KLFEMFDKLYILSQGQCIFKGVVTNLIPYLKGLGLHCPTYHNPADFIIEVASGEYGDLNPMLFRA 327

  Fly   411 VKSGACKKYAHKDYVLTLAQKGCNNDIIKGSGSGAENAMAILTLEDEKPPLEDRQLEPSIPVDDP 475
            |::|.|          |:|:|         ..|..:|                     .:|...|
Mouse   328 VQNGLC----------TMAEK---------KSSPGKN---------------------ELPAHCP 352

  Fly   476 AELKPPKLETQQSQNSDCSVVNMPTNAVDDSCSFSSSKGTQNAVGGSGSGGPSAVVGCMTSLLDS 540
            .  .||:|:.                                                    ::|
Mouse   353 T--CPPELDP----------------------------------------------------IES 363

  Fly   541 HESVVTLPNKTGFPTSGWTQFWILLKRSFRTILRDKMLTHMRLFSHVIVGAIIGMIYYDVGNEAS 605
            |.          |.||..|||.||.:|:|.:||||.:|||:|..|||::|.:||::|..:|::||
Mouse   364 HT----------FATSTLTQFCILFRRTFLSILRDTVLTHLRFMSHVLIGVLIGLLYLHIGDDAS 418

  Fly   606 KIMSNAGCIFFVSLFTTFTAMMPTILTFPTEMSVFVREHLNYWYSLKAFYFAKTIADMPFQIVFS 670
            |:.:|.|.:||..||..|.|:|||:||||.||:||:||||||||:|||:|.|||:||:|||:|..
Mouse   419 KVFNNTGFLFFSMLFLMFAALMPTVLTFPLEMAVFMREHLNYWYTLKAYYLAKTMADVPFQVVCP 483

  Fly   671 SVYVLVVYYLTSQPMELERVSMFVLICVLNSLVAQSLGLLIG-AGMNIETGVFLGPVTTIPTILF 734
            .||..:||::|.||.|..|..:|..:.:..:||||||||||| |..:::...|:||||.||.:||
Mouse   484 VVYCSIVYWMTGQPAETSRFLLFSALAIATALVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLF 548

  Fly   735 SGFFVNFDTIPGYLQWVTYVSYVRYGFEGAMVAIYGMDRAKMQCNQMYCHYRVPKKFLEEMSMDN 799
            |||||:|.|||.||||.:|:|||||||||.::.||||:|..:.|....|.:|.|:..|.|:.::.
Mouse   549 SGFFVSFKTIPTYLQWSSYLSYVRYGFEGLILTIYGMERGHLTCLDEQCPFRDPQIILRELDVEE 613

  Fly   800 ALFWVDAVALIGIFF-ALRIIAYFVLRWKL 828
            |..::|.:.| |||| |||::||.|||:::
Mouse   614 AKLYMDFLVL-GIFFLALRLLAYLVLRYRV 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atet	NP_001097079.1	3a01204	137..825	CDD:273361	335/692 (48%)
		ABCG_EPDR	142..366	CDD:213180	142/226 (63%)
		ABC2_membrane	564..767	CDD:279410	116/203 (57%)
Abcg4	NP_620405.3	3a01204	44..646	CDD:273361	340/711 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831353
Domainoid	1	1.000	273	1.000	Domainoid score	I1783
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H75179
Inparanoid	1	1.050	695	1.000	Inparanoid score	I679
Isobase	1	0.950	-	0	Normalized mean entropy	S2781
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	1	1.100	-	-	LDO	PTHR48041
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.700