DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atet and wht-5

DIOPT Version :9

Sequence 1:	NP_001097079.1	Gene:	Atet / 33636	FlyBaseID:	FBgn0020762	Length:	832	Species:	Drosophila melanogaster
Sequence 2:	NP_502352.1	Gene:	wht-5 / 178182	WormBaseID:	WBGene00008950	Length:	695	Species:	Caenorhabditis elegans

Alignment Length:	835	Identity:	215/835 - (25%)
Similarity:	349/835 - (41%)	Gaps:	190/835 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 PNRVSDSAATTAPNAVLYTSGNMSLSTLST-GSGNPNPNPNASTNSRQEPVP-LLSQLKLTNDL- 89
            |..|.|....|            ||....| .|.:|.|.|.        |:| |::...:.:::
Worm    14 PKNVEDEGLIT------------SLDVDPTQKSRSPTPKPT--------PIPVLINDTPVASEIE 58

  Fly    90 ---KQNSHGSQNNLCNGGLGSNNHALAPKVANNSGGSPNGQKKGTIALSHLPQRPPVDIEFCDIS 151
               |:.:|.|:.......|...|...:.::.  |....|.:|                :.|.:|.
Worm    59 QVEKELAHSSERFRKPKTLSVTNDTESARIP--SQVKTNAKK----------------LVFQNIQ 105

  Fly   152 YSVTDSHRRGFK-TILKSVSGKFRNGEITAIMGPSGAGKSTLMNILAG--YKTAQLSGSVLINSK 213
            ..|.  .::|.: .|||.:.|..|.||:|.|||.|||||:||:|||.|  .|..:..|.::||.:
Worm   106 AVVL--KKKGVRQEILKKIDGVARPGELTFIMGSSGAGKTTLLNILTGRNLKNIETDGDIMINGR 168

  Fly   214 ERNLRRFRKLSCYIMQDDVLIANLTVREAMMVAANLK----LGKNMISYAKVVVVEEILETIGLK 274
            .......:|||.|:.||||.|..|||||.:..||.|:    ||...:.    .:|:|:|..:.||
Worm   169 NMISNEMKKLSAYVQQDDVFIGTLTVRETLRFAAKLRSPSALGATELD----SIVDELLVMMSLK 229

  Fly   275 E----SVNTLT-CNLSGGQRKRLSIALELVNNPPVMFFDEPTSGLDSSTCFQLISLLRSLARGGR 334
            :    .|.|:| .:||.|:||||:.|.|::.:||::|.|||||||||....|:|..||.|...|:
Worm   230 KCENTKVGTMTEKSLSRGERKRLAFACEILTDPPILFCDEPTSGLDSFMSHQVIKALRQLTIEGK 294

  Fly   335 TIVCTIHQPSARLFEKFDHLYLLAQGQCVYEGRVKGLVPYLSSLGYECPSYHNPADYVLEVASGE 399
            |::|||||||..::...|.|.||:||...|.|..|.:..:....||..|.:.:..|:.:.|.|
Worm   295 TVICTIHQPSTSVYHMADQLILLSQGHVAYAGPAKQVDAFFGRCGYPIPKFVSSPDHFMRVIS-- 357

  Fly   400 YGDAVPKLVDAVKSGACKKYAHKDYVLTLAQKGCNNDIIKGSGSGAENAMAILTLEDEKPPLEDR 464
                                 ||.:.                           |.:|....:|..
Worm   358 ---------------------HKSFE---------------------------TEDDYNKRIEKI 374

  Fly   465 QLEPSIPVDDPAELKPPKLETQQSQNSDCSVVNMPTNAVDDSCSFSSSKGTQNAVGGSGSGGPSA 529
            .||..|            ::.:||.:|                :.|||:
Worm   375 VLEHDI------------MKKEQSTHS----------------TLSSSR---------------- 395

  Fly   530 VVGCMTSLLDSHESVVTLPNKTGFPTSGWTQFWILLKRSFRTILRDKMLTHMRLFSHVIVGAIIG 594
                       .|...|.|  ..||.:...||:.:.:||...:.|::.:..::|...:|:..:||
Worm   396 -----------REHPETAP--FTFPRTWTAQFFFIFQRSSIQLWRERSVLLVKLIQTLIMSIMIG 447

  Fly   595 MIYYDVGNEASKIMSNAGCIFFVSLFTTFTAMMPTILTFPTEMSVFVREHLNYWYSLKAFYFAKT 659
            ..||.:..:...:.|..|..|..........|||.:..|..:..|.|||.....||..|:|.|||
Worm   448 STYYGLEIDKKSLPSFKGFAFVSVQMMHMLFMMPAMTVFWKDYPVVVREFQANMYSPSAYYLAKT 512

  Fly   660 IADMPFQIVFSSVYVLVVYYLTSQPMELERVSMFVLICVLNSL----VAQSLGLLIGAGMNIETG 720
            .||....:||..::..::..:||.|..:..::.:::|.:|.||    |.||...:.|   ::.||
Worm   513 TADSIQYLVFPVIFSGILLGMTSLPYSVVIITNYLIINILLSLNACSVGQSFAAMCG---HLATG 574

  Fly   721 VFLGPVTTIPTILFSGFFVNFDTIPGYLQWVTYVSYVRYGFEGAMVAIYGMDRAKMQCN------ 779
            :.:.|:..:|.::|.||.:.::.||.|.....:||:.:||||...:..:..:.....|.
Worm   575 MTVLPIVCVPLMVFGGFMITYEAIPWYFLPFAWVSWYKYGFEAITIVYFNHNSTISGCESNSSVA 639

  Fly   780 ------QMYCHYRVPKKFLEEMSMDNALFWVDAVALIGIFFALRIIAYFVLRWKL 828
                  ...|...:  :|::..:.:....|:|...::.:....:|:...:..|::
Worm   640 TLKMSIDSNCTTGI--EFIKAQAFEETHLWLDYTVILAVILFWKILGALLFTWRI 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atet	NP_001097079.1	3a01204	137..825	CDD:273361	192/715 (27%)
		ABCG_EPDR	142..366	CDD:213180	99/235 (42%)
		ABC2_membrane	564..767	CDD:279410	58/206 (28%)
wht-5	NP_502352.1	3a01204	88..695	CDD:273361	196/741 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.710