DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atet and Abcg5

DIOPT Version :9

Sequence 1:	NP_001097079.1	Gene:	Atet / 33636	FlyBaseID:	FBgn0020762	Length:	832	Species:	Drosophila melanogaster
Sequence 2:	NP_446206.2	Gene:	Abcg5 / 114628	RGDID:	620298	Length:	652	Species:	Rattus norvegicus

Alignment Length:	719	Identity:	170/719 - (23%)
Similarity:	307/719 - (42%)	Gaps:	149/719 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 LAPKVA---NNSGGSPNGQKKGTIALSHLPQRPPVDIEFCDISYSVTD----------SHRRGFK 163
            |:|:.|   :|:.||.:..::|::..|....    .:...::|:||::          ..::..:
  Rat     7 LSPEGARGPHNNRGSQSSLEEGSVTGSEARH----SLGVLNVSFSVSNRVGPWWNIKSCQQKWDR 67

  Fly   164 TILKSVSGKFRNGEITAIMGPSGAGKSTLMNILAG--YKTAQLSGSVLINSKERNLRRFRKLSCY 226
            .|||.||....:|:...|:|.||:||:||::.::|  .:|..|.|.|.:|..|....:|:....|
  Rat    68 KILKDVSLYIESGQTMCILGSSGSGKTTLLDAISGRLRRTGTLEGEVFVNGCELRRDQFQDCVSY 132

  Fly   227 IMQDDVLIANLTVREAMMVAANLKLGKNMIS-YAKVVVVEEILETIGLKESVNTLTCN-----LS 285
            ::|.||.:::|||||.:...|.|.|..:... |.|  .||.:|..:.|....:.:..|     :|
  Rat   133 LLQSDVFLSSLTVRETLRYTAMLALRSSSADFYDK--KVEAVLTELSLSHVADQMIGNYNFGGIS 195

  Fly   286 GGQRKRLSIALELVNNPPVMFFDEPTSGLDSSTCFQLISLLRSLARGGRTIVCTIHQPSARLFEK 350
            .|:|:|:|||.:|:.:|.||..||||:|||..|...::.||..|||..|.::.|||||.:.||..
  Rat   196 SGERRRVSIAAQLLQDPKVMMLDEPTTGLDCMTANHIVLLLVELARRNRIVIVTIHQPRSELFHH 260

  Fly   351 FDHLYLLAQGQCVYEGRVKGLVPYLSSLGYECPSYHNPADYVLEVASGEYGDAVPKLVDAVKSGA 415
            ||.:.:|..|:.|:.|..:.::.:.::.||.||.:.||.|:.:::.|          ||...
  Rat   261 FDKIAILTYGELVFCGTPEEMLGFFNNCGYPCPEHSNPFDFYMDLTS----------VDTQS--- 312

  Fly   416 CKKYAHKDYVLTLAQKGCNNDIIKGSGSGAENAMAILTLEDEKPPLEDRQLEPSIPVDDPAELKP 480
                                                          .:|::|....|.
  Rat   313 ----------------------------------------------REREIETYKRVQ------- 324

  Fly   481 PKLETQQSQNSDCSVVNMPTNAVDDSCSFSSSKGTQNAVGGSGSGGPSAVVGCMTSLLDSHESVV 545
             .||:...|:..|..:            ..:.:.|::.                       :::.
  Rat   325 -MLESAFRQSDICHKI------------LENIERTRHL-----------------------KTLP 353

  Fly   546 TLPNKTGFPTSGWTQFWILLKRSFRTILRDKMLTHMRLFSHVIVGAIIGMIYYDVGNEASK--IM 608
            .:|.||..|...:.:..:||:|..|.::|:|.:..|||..::|:|..:......|.|...|  :.
  Rat   354 MVPFKTKNPPGMFCKLGVLLRRVTRNLMRNKQVVIMRLVQNLIMGLFLIFYLLRVQNNMLKGAVQ 418

  Fly   609 SNAGCIFFVSLFTTFTAMMPTILTFPTEMSVFVREHLNYWYSLKAFYFAKTIADMPFQIVFSSVY 673
            ...|.::.:...|.:|.|:..:..||...:|..:|..:..|.......|..:..:||.||.:.::
  Rat   419 DRVGLLYQLVGATPYTGMLNAVNLFPMLRAVSDQESQDGLYQKWQMLLAYVLHALPFSIVATVIF 483

  Fly   674 VLVVYYLTSQPMELERVSMFVLICVLNSLVAQSLGL-LIGAGMN---IETGVFLGPVTTIPTILF 734
            ..|.|:......|:.|...|....:...|:.:.|.| |:|...|   :.:.|.|..::.:  ::.
  Rat   484 SSVCYWTLGLYPEVARFGYFSAALLAPHLIGEFLTLVLLGMVQNPNIVNSIVALLSISGL--LIG 546

  Fly   735 SGFFVNFDTIPGYLQWVTYVSYVRYGFEGAMV-AIYGMDRAKMQC--------NQMYCHYRVPKK 790
            |||..|.:.:|..|:.:.|.::.:|..|..:| ..||::   ..|        |...|......:
  Rat   547 SGFIRNIEEMPIPLKILGYFTFQKYCCEILVVNEFYGLN---FTCGGSNTSVPNNPMCSMTQGIQ 608

  Fly   791 FLEE 794
            |:|:
  Rat   609 FIEK 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atet	NP_001097079.1	3a01204	137..825	CDD:273361	162/691 (23%)
		ABCG_EPDR	142..366	CDD:213180	81/241 (34%)
		ABC2_membrane	564..767	CDD:279410	51/209 (24%)
Abcg5	NP_446206.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30		7/22 (32%)
		ABCG_White	50..276	CDD:213201	78/227 (34%)
		3a01204	61..646	CDD:273361	159/661 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810