DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atet and Abcg1

DIOPT Version :9

Sequence 1:	NP_001097079.1	Gene:	Atet / 33636	FlyBaseID:	FBgn0020762	Length:	832	Species:	Drosophila melanogaster
Sequence 2:	NP_033723.1	Gene:	Abcg1 / 11307	MGIID:	107704	Length:	666	Species:	Mus musculus

Alignment Length:	772	Identity:	371/772 - (48%)
Similarity:	486/772 - (62%)	Gaps:	126/772 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 NASTNSRQEPVPLLSQLKLTNDLKQNSHGSQNNLCNGGLGSNNHALAPKVANNSGGSPNGQKKGT 131
            |||:.|.....|....:.:...:..|....:.:|.||.|        .||.||   ....|:
Mouse    15 NASSYSAAMTEPKSVCVSVDEVVSSNVDEVETDLLNGHL--------KKVDNN---FTEAQR--- 65

  Fly   132 IALSHLPQRPPVDIEFCDISYSVTDS---HRRGFKTILKSVSGKFRNGEITAIMGPSGAGKSTLM 193
              .|.||:|..|:|||.|:||||.:.   .::|:||:||.:||||.:||:.||||||||||||||
Mouse    66 --FSSLPRRAAVNIEFKDLSYSVPEGPWWKKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLM 128

  Fly   194 NILAGYKTAQLSGSVLINSKERNLRRFRKLSCYIMQDDVLIANLTVREAMMVAANLKLGKNMISY 258
            ||||||:...:.|:||||...|:||.|||:||||||||:|:.:|||:|||||:|:|||.:.  ..
Mouse   129 NILAGYRETGMKGAVLINGMPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEK--DE 191

  Fly   259 AKVVVVEEILETIGLKESVNTLTCNLSGGQRKRLSIALELVNNPPVMFFDEPTSGLDSSTCFQLI 323
            .:..:|:|||..:||....||.|.:|||||||||:|||||||||||||||||||||||::|||::
Mouse   192 GRREMVKEILTALGLLPCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVV 256

  Fly   324 SLLRSLARGGRTIVCTIHQPSARLFEKFDHLYLLAQGQCVYEGRVKGLVPYLSSLGYECPSYHNP 388
            ||::.||:|||:||||||||||:|||.||.||:|:||||||.|:|..|||||..||..||:||||
Mouse   257 SLMKGLAQGGRSIVCTIHQPSAKLFELFDQLYVLSQGQCVYRGKVSNLVPYLRDLGLNCPTYHNP 321

  Fly   389 ADYVLEVASGEYGDAVPKLVDAVKSGACKKYAHKDYVLTLAQKGCNNDIIKGSGSGAENAMAILT 453
            ||:|:|||||||||...:||.||:.|.|    ..||...|   |.:.|:
Mouse   322 ADFVMEVASGEYGDQNSRLVRAVREGMC----DADYKRDL---GGDTDV---------------- 363

  Fly   454 LEDEKPPLEDRQLEPSIPVDDPAELKPPKLETQQSQNSDCSVVNMPTNAVDDSCSFSSSKGTQNA 518
                .|.|..|          |||                          :||.|..
Mouse   364 ----NPFLWHR----------PAE--------------------------EDSASME-------- 380

  Fly   519 VGGSGSGGPSAVVGCMTSLLDSHESVVTLPNKTGFPTSGWTQFWILLKRSFRTILRDKMLTHMRL 583
                         ||.:                 |..|..|||.||.||:|.:|:||.:|||:|:
Mouse   381 -------------GCHS-----------------FSASCLTQFCILFKRTFLSIMRDSVLTHLRI 415

  Fly   584 FSHVIVGAIIGMIYYDVGNEASKIMSNAGCIFFVSLFTTFTAMMPTILTFPTEMSVFVREHLNYW 648
            .||:.:|.:||::|..:||||.|::||:|.:||..||..|.|:|||:||||.|||||:|||||||
Mouse   416 TSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMSVFLREHLNYW 480

  Fly   649 YSLKAFYFAKTIADMPFQIVFSSVYVLVVYYLTSQPMELERVSMFVLICVLNSLVAQSLGLLIG- 712
            |||||:|.|||:||:||||:|...|..:||::||||.:..|..:|..:..:.||||||||||||
Mouse   481 YSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVAQSLGLLIGA 545

  Fly   713 AGMNIETGVFLGPVTTIPTILFSGFFVNFDTIPGYLQWVTYVSYVRYGFEGAMVAIYGMDRAKMQ 777
            |..:::...|:||||.||.:|||||||:|||||.||||::|:|||||||||.:::|||:||..:.
Mouse   546 ASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPAYLQWMSYISYVRYGFEGVILSIYGLDREDLH 610

  Fly   778 CN-QMYCHYRVPKKFLEEMSMDNALFWVDAVALIGIFF-ALRIIAYFVLRWKLHMIR 832
            |: ...||::..:..|.|:.::||..::|.:.| |||| :||:|||||||:|:...|
Mouse   611 CDIAETCHFQKSEAILRELDVENAKLYLDFIVL-GIFFISLRLIAYFVLRYKIRAER 666

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atet	NP_001097079.1	3a01204	137..825	CDD:273361	351/693 (51%)
		ABCG_EPDR	142..366	CDD:213180	147/226 (65%)
		ABC2_membrane	564..767	CDD:279410	121/203 (60%)
Abcg1	NP_033723.1	3a01204	60..666	CDD:273361	356/714 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831348
Domainoid	1	1.000	273	1.000	Domainoid score	I1783
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	695	1.000	Inparanoid score	I679
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177791at33208
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	1	1.100	-	-	O	PTHR48041
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.760