DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bdl and IGDCC3

DIOPT Version :9

Sequence 1:	NP_608822.1	Gene:	bdl / 33635	FlyBaseID:	FBgn0028482	Length:	719	Species:	Drosophila melanogaster
Sequence 2:	NP_004875.2	Gene:	IGDCC3 / 9543	HGNCID:	9700	Length:	814	Species:	Homo sapiens

Alignment Length:	746	Identity:	178/746 - (23%)
Similarity:	278/746 - (37%)	Gaps:	135/746 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPAKRSRTFRQSGSALL-ALLAIILLMNISCTSAARDHRRQ-------TNLEAKVGSHVVFNCYI 57
            |..:|:.:.|:..:.|. .||..:||:.:...|....|..:       ::..|..|..:|.:|.:
Human     1 MAVQRAASPRRPPAPLWPRLLLPLLLLLLPAPSEGLGHSAELAFAVEPSDDVAVPGQPIVLDCRV 65

  Fly    58 DFPFDAPIPYLVHWTKDNKKIFTWYEQETSTSELFNGRLHLVENHPEFGRASVNLTAIRESDQGW 122
            :   ..| |..:.|.|:..::    .:.|.::.|.||.|.:.....|.|.:        .||:|.
Human    66 E---GTP-PVRITWRKNGVEL----PESTHSTLLANGSLMIRHFRLEPGGS--------PSDEGD 114

  Fly   123 YHCQVSFPNRSPSVRNNGTAYHLAVQGGSLIRIPPVNQTIREGQTAFFHCVMKHPENSQASWYKD 187
            |.|...  ||...|.:.......|..  |...:.|......||..|.|.|.:........:|.|:
Human   115 YECVAQ--NRFGLVVSRKARIQAATM--SDFHVHPQATVGEEGGVARFQCQIHGLPKPLITWEKN 175

  Fly   188 GVLLQEVQDLVRRFYMGPDGSLSIDPTMMSDLGEYEC------KVRNSDGELQTAKAFLNIQYKA 246
            .|.:....:   |:.:.|.|.|.|......|.|.:.|      .:|.|.|...|.....:..||.
Human   176 RVPIDTDNE---RYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGARLTVSGSGSGAYKE 237

  Fly   247 KVIYAPPE-VFLPYGQPAVLDCHFRANP-PLKNLRWEK-DGLLFDSYNVPGVFYKMNGSLFFAKV 308
            ..|...|| :.|...|.|||:|....|| |:  :.|.: ||   ....|.|:.....|:|..:.|
Human   238 PAILVGPENLTLTVHQTAVLECVATGNPRPI--VSWSRLDG---RPIGVEGIQVLGTGNLIISDV 297

  Fly   309 DENHAGSYTCTPYNDLGT------DGPSPVISVIVLRPPIFSVTPKAIYIQKLGEAAELPCEAID 367
            ...|:|.|.|.. |..||      .|     .::|..|..|...|::| .:..|..|...|:|
Human   298 TVQHSGVYVCAA-NRPGTRVRRTAQG-----RLVVQAPAEFVQHPQSI-SRPAGTTAMFTCQA-- 353

  Fly   368 RDGNNRPSIIWGRKDGQPL-PADRFSLSGGN--LTITGLVEGDRGIYECSATNEAATITAEAELM 429
             .|...|.:.| .|:||.| |.....|...|  |||:|:...|..||:|.|.|.|.:..|.|.|.
Human   354 -QGEPPPHVTW-LKNGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLT 416

  Fly   430 I---ENIAPRAPYNLTA---NSTETCITIRW-QPGYLRPNLEYTVWY-----RLMEAPEWRTLRV 482
            :   |.: |..|.|:.|   :|||  :.:.| :|   ..|.:..:.|     :..:.||......
Human   417 VLWAEGL-PGPPRNVRAVSVSSTE--VRVSWSEP---LANTKEIIGYVLHIRKAADPPELEYQEA 475

  Fly   483 LDKKVMEATVQHLQPGKEYEFMVLSQDKYGDGMFSKQFRFQTLPSPIRADDFDAQQLQHDLGQVT 547
            :.|...:..|..|:|...|.|.:.:.                  :|..|.......|...||:..
Human   476 VSKSTFQHLVSDLEPSTAYSFYIKAY------------------TPRGASSASVPTLASTLGEAP 522

  Fly   548 APAGGLGAPWNLTAISNQQGWLL--HWEHPVQGLEGLRLY---AVRWWKEPEHFLIGHAETFDNY 607
            ||     .|.::..:.:....||  .|....|...|.:|:   |.:........|.|...:
Human   523 AP-----PPLSVRVLGSSSLQLLWEPWPRLAQHEGGFKLFYRPASKTSFTGPILLPGTVSS---- 578

  Fly   608 YQLRHLKEDTLFKVQVLAV-----GTETQQSV----PSHELLIDVP---------SQRKVRALII 654
            |.|..|....:::|::||.     |..|.:.|    .|....:..|         :|.....::|
Human   579 YNLSQLDPTAVYEVKLLAYNQHGDGNATVRFVSLRGASERTALSPPCDCRKEEAANQTSTTGIVI 643

  Fly   655 GSSVGVIFLLCALCAFLYVKRSCLRHLFAKD 685
            |..:||..::..:...|:.:|.  |.|..||
Human   644 GIHIGVTCIIFCVLFLLFGQRG--RVLLCKD 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bdl	NP_608822.1	IG_like	42..128	CDD:214653	20/85 (24%)
		Ig	43..131	CDD:299845	20/87 (23%)
		I-set	153..242	CDD:254352	21/94 (22%)
		Ig	157..242	CDD:299845	21/90 (23%)
		Ig_2	252..337	CDD:290606	27/93 (29%)
		IG_like	260..327	CDD:214653	23/74 (31%)
		I-set	341..428	CDD:254352	30/89 (34%)
		IGc2	356..419	CDD:197706	24/65 (37%)
		FN3	435..524	CDD:238020	19/97 (20%)
		FN3	554..636	CDD:238020	19/95 (20%)
IGDCC3	NP_004875.2	Ig	44..135	CDD:299845	23/108 (21%)
		IG_like	48..128	CDD:214653	23/97 (24%)
		Ig	143..227	CDD:299845	20/86 (23%)
		IG_like	145..227	CDD:214653	20/84 (24%)
		Ig	242..326	CDD:299845	27/94 (29%)
		IG_like	244..326	CDD:214653	27/92 (29%)
		I-set	331..417	CDD:254352	31/90 (34%)
		Ig	347..414	CDD:143165	25/70 (36%)
		FN3	424..517	CDD:238020	22/115 (19%)
		fn3	522..603	CDD:278470	18/89 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	722..743
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	762..814
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910