DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bdl and dscama

DIOPT Version :9

Sequence 1:	NP_608822.1	Gene:	bdl / 33635	FlyBaseID:	FBgn0028482	Length:	719	Species:	Drosophila melanogaster
Sequence 2:	XP_021334866.1	Gene:	dscama / 568643	ZFINID:	ZDB-GENE-050310-7	Length:	2025	Species:	Danio rerio

Alignment Length:	765	Identity:	166/765 - (21%)
Similarity:	255/765 - (33%)	Gaps:	221/765 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 EAKVGSH--VVFNCYIDFPFDAPIPYLVHWTKDNKKIFTWYEQETSTSELFNGRLHLVENHPEFG 106
            |..||.:  |...|::.   ..|.| .:.||.|::.:..            :.|..:|.:....|
Zfish   416 EKVVGPNDFVSLTCHVK---GTPQP-AITWTLDDEVVAK------------DSRHRIVHSITAEG 464

  Fly   107 R--ASVNLTAIRESDQGWYHCQVSFPNRSPSVRNN--GTAYHLA---VQGGSLIRIPPVNQTIRE 164
            .  :.:|::.|:..|.|.|.|..          ||  ||..:.|   |:|.:.|| |..|.|...
Zfish   465 NVVSYLNISHIQVRDSGVYRCTC----------NNSAGTVSYQARINVRGSADIR-PMKNLTAIA 518

  Fly   165 GQTAFFHC-VMKHPENSQASWYKDGVLLQEVQDLVRRFYMGPDGSLS-IDPTMMSDLGEYECKVR 227
            |...:.|| |:.:|..| ..|:|:..|| ...|..|.|  ..:|:|. ::.....|.|||.|.|
Zfish   519 GWDMYIHCHVIGYPYYS-IKWFKNSNLL-PFNDRQRAF--ENNGTLKLLNVQKELDEGEYSCHV- 578

  Fly   228 NSDGELQTAKAFLNIQYKAKVIYAPPEV----FLPY--GQPAVLDCHFRANPPLKNLRWEKDGLL 286
                  |........|.....:..||.:    |..|  |....:.|..|:.....::.|||||..
Zfish   579 ------QVQPQLFKNQSVHVTVKVPPFIQPFEFPRYSIGHRVFVPCVVRSGDLPISITWEKDGKS 637

  Fly   287 FD-SYNVPGVFYKMNGSLFFAKVDENHAGSYTCTPYNDLGTDGPSPVI----SVIVLRPPIFSVT 346
            .: |..|.........||..:.:...|.|:|||...||      :.|:    .:||..||.|.|.
Zfish   638 INASLGVTIDNIDFTSSLRISNLQRVHNGTYTCIAQND------AAVVKYQSQLIVRVPPRFKVQ 696

  Fly   347 PK---AIYIQKLGEAAELPCEAIDRDGNNRPSIIWGRKDG------QPLPAD---RFSLSG-GNL 398
            |:   .||    |::..|.|.|   ||..||:|.|....|      ||:..:   |..|.| |:|
Zfish   697 PQDQDGIY----GKSVILNCSA---DGEPRPTIEWKYSKGAGVPQFQPIALNSGFRVQLLGNGSL 754

  Fly   399 TITGLVEGDRGIYECSATNEAATITAEA---ELMIENIAPRAPYNLTANSTE----TC------- 449
            .|..::|.|.|.|.|..:|:.....:::   .:.|..:....|.|..|...|    :|
Zfish   755 LIKHVLEEDAGYYLCKVSNDVGADVSKSMYLNVKIPAMITSYPNNSLATKGEKIEMSCKAHGEKP 819

  Fly   450 ITIRW--------QPGYLRPNL-EYTVWYR----------------------------------- 470
            |.:||        |...:.|:: .:||..:
Zfish   820 IMVRWEKEVEKEKQSHMINPDMWRHTVTVKNVGDEVVSTLQIYPTMREDSGFFSCHAINSYGEDR 884

  Fly   471 ------LMEAPE-----------------------------------------W---RTLRVLDK 485
                  :.|.||                                         |   |..|.:..
Zfish   885 GILQLTVQEPPEPPKVEIREVKERTIALRWTMGFDGNSLITGYDIECKNKTETWERARRTRDVSP 949

  Fly   486 KVMEATVQHLQPGKEYEFMVLSQDKYGDGMFSKQFRFQTLPSPIRADDFDAQQLQHDLGQVTAPA 550
            .:.:||:..|.|...|...:.:::..||...|.:....|       |:.|.:....|:......:
Zfish   950 TLNQATIIELHPSSTYNIRMFAKNHIGDSEPSNELTVTT-------DEADPEGPPQDVTLEAITS 1007

  Fly   551 GGLGAPWNLTAISNQQG-----WLLHWEHPVQGLEGLRLYAVRWWKEPEHFLIGHAETFDNYYQL 610
            ..:...|.......|.|     .:.|.||...|.......:|....|.|..            .|
Zfish  1008 QSIKVTWKAPLKHLQNGVIRGYQVCHREHSTNGSHQFVCISVEATGETESL------------SL 1060

  Fly   611 RHLKEDTLFKVQVLA---VGTETQQSVPSHELLIDVPSQRKVRALIIGSS 657
            .:||:...::|.|.|   .|.....|......:.||||:...:.:...:|
Zfish  1061 NNLKKFAEYEVVVQASNSAGPGPASSEVRATTMEDVPSRAPEKVVATAAS 1110

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bdl	NP_608822.1	IG_like	42..128	CDD:214653	19/87 (22%)
		Ig	43..131	CDD:299845	19/90 (21%)
		I-set	153..242	CDD:254352	27/90 (30%)
		Ig	157..242	CDD:299845	24/86 (28%)
		Ig_2	252..337	CDD:290606	24/95 (25%)
		IG_like	260..327	CDD:214653	19/67 (28%)
		I-set	341..428	CDD:254352	31/102 (30%)
		IGc2	356..419	CDD:197706	25/72 (35%)
		FN3	435..524	CDD:238020	26/193 (13%)
		FN3	554..636	CDD:238020	18/89 (20%)
dscama	XP_021334866.1	Ig	124..217	CDD:325142
		I-set	236..311	CDD:254352
		IG_like	321..402	CDD:214653
		I-set	408..502	CDD:333254	24/111 (22%)
		IGc2	524..579	CDD:197706	20/65 (31%)
		Ig	614..679	CDD:319273	18/70 (26%)
		Ig_DSCAM	708..787	CDD:143211	24/81 (30%)
		Ig	805..898	CDD:325142	12/92 (13%)
		FN3	894..988	CDD:238020	13/93 (14%)
		FN3	995..1092	CDD:238020	19/108 (18%)
		fn3	1100..1186	CDD:306538	1/11 (9%)
		fn3	1199..1282	CDD:306538
		Ig	1312..1377	CDD:319273
		fn3	1405..1471	CDD:306538
		FN3	1492..1563	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10075
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910