DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bdl and sdk1a

DIOPT Version :9

Sequence 1:	NP_608822.1	Gene:	bdl / 33635	FlyBaseID:	FBgn0028482	Length:	719	Species:	Drosophila melanogaster
Sequence 2:	XP_009297968.1	Gene:	sdk1a / 558391	ZFINID:	ZDB-GENE-081104-374	Length:	2245	Species:	Danio rerio

Alignment Length:	601	Identity:	140/601 - (23%)
Similarity:	219/601 - (36%)	Gaps:	133/601 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 PIPYLVHWTKDNKKIFTWYEQETSTSELFNGRLHLVENHPEFGRASVNLTAIRESDQGWYHCQVS 128
            |:|.|           .||:.....|:|.|.|..::.:      ..:.:..::.||.|.:.|
Zfish   444 PMPKL-----------EWYKDAVPLSKLNNPRYKIISS------MGLQVRKLQPSDAGIFQC--- 488

  Fly   129 FPNRSPSVRNN-GTA-YHLAVQGGSL---IRIPPVNQTIREGQTAFFHCVMKHPENSQASWYKDG 188
                  ..||: |.| .|..:...|:   ...||::.|:.:|..|.|.|.:.........|.:|.
Zfish   489 ------FARNSAGEAQVHTYLDVTSMAPAFTAPPLDITVTDGAVAAFTCRVSGAPKPAIVWRRDT 547

  Fly   189 VLLQEVQDLVRRFYMGPDGSLSIDPTMMSDLGEYECKVRNSDGELQTAKAFLNIQYKAKVIYAPP 253
            .:|......:.||.:...|.|.|.|.::.|.|.|.|...||:|.: .|.|.|.:..:..:...|.
Zfish   548 QILASGSVQIPRFTLLESGGLQIQPVVLQDTGNYTCYAANSEGAI-NASASLTVWSRTSISSPPT 611

  Fly   254 EVFLPYGQPAVLDCHFRANPPLKNLR--WEKDGLLFDSYNVPGVFYKMNGSLFFAKVDENHAGSY 316
            :..:..|..|:|:|. ..:.|...:|  |:||..|. |::..|......|||..::......|:|
Zfish   612 DRRVIKGTTAILECG-ATHDPRVGVRYVWKKDEELV-SHSRGGRISLQEGSLHISQTWSGDIGNY 674

  Fly   317 TCTPYNDLGTDGPSPVISVIVL-----------------------RPPIFSVTPKAIYIQKLGEA 358
            ||...::.|.:.....:.||.|                       ..|....:|...|:.:|.|
Zfish   675 TCDVISEAGNESKEARLEVIELPHSPRNLQASLNANDSRSVDLSWMRPFDGNSPLLHYVVELSE- 738

  Fly   359 AELPCEAIDRDGNNRPSIIWGRKDGQPLPADRFSLSGGNLTITGLVEGDRGIYECSATNEAAT-- 421
                        ||.|..:: ..|..|        ||....:.||.......:...|.|:...
Zfish   739 ------------NNSPWRVY-LSDVDP--------SGTGAMVKGLTPARSYQFRVCAVNQVGRGQ 782

  Fly   422 -ITAEAELMIENIAPRA-PYNLTANS-TETCITIRWQP-------GYLRPNLEYTVWYRLMEAP- 475
             .|....||:....|.| |.|:.|:. |...|.::|||       |.||   .|.:.|||...|
Zfish   783 YSTETNRLMLREEPPSAPPKNIVASGRTNQSIMVQWQPPPEPQLNGVLR---GYVLRYRLAGLPG 844

  Fly   476 EWRTLRVLDKKVMEATVQHLQPGKEYEFMVLSQDKYGDGMFSKQFRFQTLPSPIRADDFDAQQLQ 540
            |::...:...::....:..|....:||..|.:....|.|:||:.....||.
Zfish   845 EYQQKNISSPEINYCLITELIIWTQYEIQVAAYTGAGLGVFSQPVTEYTLQ-------------- 895

  Fly   541 HDLGQVTAPAGGLGA-PWNLTAISNQQGWLLHWEHP----VQGL-EGLRLYAVRWWKE--PEHFL 597
               |..|||..|:.| ..|.|.|.      ..|..|    :.|: :|.:|.|   |.|  ||..:
Zfish   896 ---GVPTAPPQGVEAKAVNSTTIE------FSWNPPPQQFINGINQGYKLMA---WPERSPEEVI 948

  Fly   598 IGHAETFDNYYQLRHL 613
            :  .....:|:..|||
Zfish   949 V--VTITPDYHGTRHL 962

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bdl	NP_608822.1	IG_like	42..128	CDD:214653	13/63 (21%)
		Ig	43..131	CDD:299845	13/66 (20%)
		I-set	153..242	CDD:254352	26/88 (30%)
		Ig	157..242	CDD:299845	25/84 (30%)
		Ig_2	252..337	CDD:290606	22/86 (26%)
		IG_like	260..327	CDD:214653	20/68 (29%)
		I-set	341..428	CDD:254352	17/89 (19%)
		IGc2	356..419	CDD:197706	12/62 (19%)
		FN3	435..524	CDD:238020	27/98 (28%)
		FN3	554..636	CDD:238020	18/68 (26%)
sdk1a	XP_009297968.1	I-set	125..208	CDD:254352
		Ig	125..204	CDD:299845
		IG_like	222..302	CDD:214653
		Ig	236..287	CDD:299845
		Ig_3	322..394	CDD:290638
		I-set	323..412	CDD:254352
		I-set	416..505	CDD:254352	18/86 (21%)
		Ig	436..500	CDD:299845	17/81 (21%)
		I-set	510..600	CDD:254352	26/90 (29%)
		Ig	527..600	CDD:299845	22/73 (30%)
		I-set	605..693	CDD:254352	21/89 (24%)
		Ig	610..693	CDD:299845	21/84 (25%)
		FN3	697..788	CDD:238020	17/112 (15%)
		fn3	800..886	CDD:278470	23/88 (26%)
		FN3	901..997	CDD:238020	20/73 (27%)
		FN3	1002..1090	CDD:238020
		FN3	1100..1196	CDD:238020
		FN3	1206..1301	CDD:238020
		FN3	1308..1397	CDD:238020
		FN3	1408..1501	CDD:238020
		FN3	1507..1602	CDD:238020
		FN3	1616..1722	CDD:238020
		FN3	1732..1825	CDD:238020
		FN3	1830..1919	CDD:238020
		FN3	1931..2021	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900