DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bdl and igsf9b

DIOPT Version :9

Sequence 1:	NP_608822.1	Gene:	bdl / 33635	FlyBaseID:	FBgn0028482	Length:	719	Species:	Drosophila melanogaster
Sequence 2:	XP_686205.6	Gene:	igsf9b / 553348	ZFINID:	ZDB-GENE-060810-28	Length:	2021	Species:	Danio rerio

Alignment Length:	729	Identity:	196/729 - (26%)
Similarity:	305/729 - (41%)	Gaps:	122/729 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 LEAKVGSHVVFNCYIDFPFDA---PIPYLVHWTKDNKKIFTWYEQETSTSELFNGRLHLVENHPE 104
            ||..:|..:..:|      ||   |.|.:: |    :|..:..|::.....|
Zfish   151 LEVLLGESLTLHC------DAHGNPKPTII-W----RKYLSAAEKQEEIQVL------------- 191

  Fly   105 FGRASVNLTAIRESDQGWYHCQVSFPNRSPSVRNNGTAYH---LAVQGGSLIRIPPVNQTIREGQ 166
              ..:::|:.:.....|.|.|.||        .:.|...|   |.|:|..:|.|.|.:.|:...|
Zfish   192 --NETLSLSKVTRETAGIYKCHVS--------NSEGNLTHSTQLQVKGPPIIIIAPEDTTMNMSQ 246

  Fly   167 TAFFHCVMK-HPENSQASWYKDGVLLQEVQDLVRRFYMGPDGSLSIDPTMMSDLGEYECKVRNSD 230
            .|...|..: :|.|....|:|.|..:..::.|..|..:..||:|.|...:..|.|.|.|:..|..
Zfish   247 DAVLQCQAEAYPSNLTYEWWKQGQNVYHIEILKSRVKILVDGTLLISALIPDDSGNYTCRPTNGL 311

  Fly   231 GELQTAKAFLNIQYKAKVIYAPPEVFLPYGQPAVLDCHFRANPPLKNLRWEKDGLLFDSYNVPGV 295
            .....|.|:|.:::.|:|:..|.|.:||.|....:.|..:|.||:..:.|.|||...:....||.
Zfish   312 MTPPAASAYLTVKHPARVVRMPRETYLPMGMGGKIPCPVQAEPPMLYVNWTKDGASLNLEQYPGW 376

  Fly   296 FYKMNGSLFFAKVDENHAGSYTCTPYNDLGTDGPSPVISVIVLRPPIFSVTPKAIYIQKLGEAAE 360
            .....||:|....:::..|.||||.||..||.|.|....||:..||.|.|:|:|.|:|::|....
Zfish   377 MVNSEGSVFITAANDDAVGMYTCTAYNSYGTMGQSEPTKVILKDPPSFRVSPRAEYLQEVGRDLV 441

  Fly   361 LPCEAIDRDGNNRPSIIWGRKDGQPLPADRFS-LSGGNLTITGLVEGDRGIYECSATNEAATITA 424
            :||::   .|:..|:|.| .|.| |.|...|: ||.|:|.:..|.:..:|.:||.|:|..||::.
Zfish   442 IPCQS---QGDPSPNITW-IKVG-PAPRSPFTVLSNGSLFLRPLSKDHQGTWECLASNRVATVSV 501

  Fly   425 EAELMIENIAPRAPYNLTANSTETCITIRWQP----GYLRPNLEYTVWYR--LMEAPEWRTLRVL 483
            ...:::...:|.|..:::.:.......:.|:.    ||.:   .:|||.:  :....||.::.|.
Zfish   502 ATTILVLGTSPHAVTSVSVDPGIGQANVSWEAGFDGGYTQ---RFTVWVKPTVRGKHEWASIPVP 563

  Fly   484 DKKVMEATVQHLQPGKEYEFMVLSQDKYGDGMFSKQFRFQTLPSPIRADDFDAQQLQHDLGQVTA 548
            ..|. ...|..|||...|:|.||:|:|.|.|.||:....:||..|..:.            .|..
Zfish   564 TSKT-SLLVTSLQPATSYQFSVLAQNKLGSGPFSEIVTIKTLAPPTESP------------TVLT 615

  Fly   549 PAGGLGAPWNLTAISNQQGWLLHWEHPVQGLEGLRLYAVR-------WWKEPEHFLIGHAETF-- 604
            ....|..|..|:|.....|.||.|..|::  |.|..:|::       |........:...|..
Zfish   616 TMAVLSPPTLLSANRTSLGVLLQWVPPLE--ESLTSFALQAKRGKGEWVTIDREIAVNMTELIVQ 678

  Fly   605 ----DNYYQLRHLK-EDTLFKV--QVLAVGTETQQSVP-SHELLIDVPSQRKVRALIIGSSVGVI 661
                |:.|:||.|. :|.|..|  ..:.:.||..:..| :..||..||     ..|:.|...||.
Zfish   679 GLVKDSKYELRLLSCQDKLVSVPSDSVLISTEGMEMYPAAPSLLAFVP-----EPLLAGVIGGVC 738

  Fly   662 FLLCALCAFLYV--------------KRSCLRHLFAKDSSASEDEDTAESGD-------C----- 700
            ||..|:...|..              ||..:...|.| |||.:....::|.|       |
Zfish   739 FLFVAIILSLVTACVMNSKRRQRRQKKRDDIPSAFQK-SSAPQANSPSDSPDSLLKLKLCPPLNF 802

  Fly   701 --DSDEQDQRDRDS 712
              :|...|:.||.|
Zfish   803 FPNSSSSDRSDRSS 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bdl	NP_608822.1	IG_like	42..128	CDD:214653	16/87 (18%)
		Ig	43..131	CDD:299845	18/90 (20%)
		I-set	153..242	CDD:254352	26/89 (29%)
		Ig	157..242	CDD:299845	24/85 (28%)
		Ig_2	252..337	CDD:290606	30/84 (36%)
		IG_like	260..327	CDD:214653	22/66 (33%)
		I-set	341..428	CDD:254352	31/87 (36%)
		IGc2	356..419	CDD:197706	22/63 (35%)
		FN3	435..524	CDD:238020	26/94 (28%)
		FN3	554..636	CDD:238020	24/98 (24%)
igsf9b	XP_686205.6	Ig	27..132	CDD:299845
		IG_like	148..227	CDD:214653	21/109 (19%)
		IGc2	156..217	CDD:197706	16/94 (17%)
		Ig	237..323	CDD:299845	24/85 (28%)
		IG_like	237..323	CDD:214653	24/85 (28%)
		Ig	345..411	CDD:143165	23/65 (35%)
		IG_like	435..507	CDD:214653	24/76 (32%)
		IGc2	437..496	CDD:197706	22/63 (35%)
		FN3	512..603	CDD:238020	26/94 (28%)
		FN3	621..709	CDD:238020	21/89 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	62	1.000	Domainoid score	I10297
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D151368at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920