DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bdl and KIRREL1

DIOPT Version :9

Sequence 1:	NP_608822.1	Gene:	bdl / 33635	FlyBaseID:	FBgn0028482	Length:	719	Species:	Drosophila melanogaster
Sequence 2:	XP_005245362.1	Gene:	KIRREL1 / 55243	HGNCID:	15734	Length:	773	Species:	Homo sapiens

Alignment Length:	834	Identity:	158/834 - (18%)
Similarity:	253/834 - (30%)	Gaps:	274/834 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LLALLAIILLMNISCTSAARDHRRQTNLEAKV--GSHVVFNCYIDFPFDAPIPY--LVHWTKD-- 74
            :|:||..||.::.:.:...:....|...:..|  |...|..|.:       :.|  :|.||||
Human     1 MLSLLVWILTLSDTFSQGTQTRFSQEPADQTVVAGQRAVLPCVL-------LNYSGIVQWTKDGL 58

  Fly    75 ----NKKIFTWYEQETSTSELFNGRLHLVENHPEFGRASVNLTAIRESDQGWYHCQ--------- 126
                .:.:..|..             :.|....:.|:.::.:|....||...|.||
Human    59 ALGMGQGLKAWPR-------------YRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSR 110

  Fly   127 -----VSFP---------------------------NRSPSVR----NNGTAYHLAVQGGSLIR- 154
                 |..|                           |..|:..    .:||....||....|::
Human   111 RAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKD 175

  Fly   155 -----------IPPVN----------------------------------------QTIREGQTA 168
                       |.|.:                                        ||::||:..
Human   176 GKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERV 240

  Fly   169 FFHC-VMKHPENSQASWYKDGVLLQEVQDLVRRFYMGPDGSLSIDPTMMSDLGEYECKVRNSDGE 232
            .|.| ...:||.....|.|.|.|:::..:  .|:....|.|...:|.        .|:|.|..|.
Human   241 VFTCQATANPEILGYRWAKGGFLIEDAHE--SRYETNVDYSFFTEPV--------SCEVHNKVGS 295

  Fly   233 LQTAKAFLNIQYKAKVIYAPPEVFLPYGQPAVLDCHFRANPPLKNLRWEKDGLLFDSYNV----P 293
            ...: ..:|:.:..:::..|.......|....|.|.:..|||| .|.|.|.    || |:    |
Human   296 TNVS-TLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPL-TLTWTKK----DS-NMGPRPP 353

  Fly   294 G----------VFYKMNGSLFFAKVDENHAGSYTCTPYNDLGTDGPSPVISV-------IVLRPP 341
            |          |....| .|....|.:..||:|||...        .|.|.|       .|..||
Human   354 GSPPEAALSAQVLSNSN-QLLLKSVTQADAGTYTCRAI--------VPRIGVAEREVPLYVNGPP 409

  Fly   342 IFSVTPKAIYIQKLGEAAELPCEAIDRDGNNRP--SIIWGRKDG-------QPLPADRFSLSGG- 396
            |  ::.:|:.....|:..::.|..    |:..|  .|.|..|:.       :....:|.:...|
Human   410 I--ISSEAVQYAVRGDGGKVECFI----GSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGV 468

  Fly   397 --NLTITGLVEGD-RGIYECSATNEAATITAEAELMIENIAPRAPYNLTANST--ETCITIRWQP 456
              .|||..::|.| :..|.|:|.|.....||..:|....:   .|..:.|.:|  .:.:.|
Human   469 LSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREV---LPVGIIAGATIGASILLI---- 526

  Fly   457 GYLRPNLEYTVWYRLMEAPEWRTLRVLDKKVMEATVQHLQPGKEYE-----------FMVLSQDK 510
             :....|.:.::.|...:.:..|||.||.||.....:.|....:.|           .|......
Human   527 -FFFIALVFFLYRRRKGSRKDVTLRKLDIKVETVNREPLTMHSDREDDTASVSTATRVMKAIYSS 590

  Fly   511 YGDGMFSKQ-FRFQTL-------------------------------------PSPIRADDFDAQ 537
            :.|.:..|| .|..|:                                     |.|.|.|...:.
Human   591 FKDDVDLKQDLRCDTIDTREEYEMKDPTNGYYNVRAHEDRPSSRAVLYADYRAPGPARFDGRPSS 655

  Fly   538 QLQHDLG-----------------QVTAPAGGLGAPWNLTAISNQQGWLLHWEHPVQGLEGLRLY 585
            :|.|..|                 :.|.|.....|..:.|:..:.:.:.....||..|..|...|
Human   656 RLSHSSGYAQLNTYSRGPASDYGPEPTPPGPAAPAGTDTTSQLSYENYEKFNSHPFPGAAGYPTY 720

  Fly   586 AVRWWKEPEHFLIGHAETFDNYYQLRHLKEDTLFKV--QVLAVGTETQQSVPSH 637
            .:.:.:.|...|  ....::.|..:......|.|..  |....|...||.:.:|
Human   721 RLGYPQAPPSGL--ERTPYEAYDPIGKYATATRFSYTSQHSDYGQRFQQRMQTH 772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bdl	NP_608822.1	IG_like	42..128	CDD:214653	19/109 (17%)
		Ig	43..131	CDD:299845	21/138 (15%)
		I-set	153..242	CDD:254352	22/141 (16%)
		Ig	157..242	CDD:299845	21/125 (17%)
		Ig_2	252..337	CDD:290606	28/105 (27%)
		IG_like	260..327	CDD:214653	24/80 (30%)
		I-set	341..428	CDD:254352	23/99 (23%)
		IGc2	356..419	CDD:197706	18/75 (24%)
		FN3	435..524	CDD:238020	20/102 (20%)
		FN3	554..636	CDD:238020	16/83 (19%)
KIRREL1	XP_005245362.1	I-set	22..116	CDD:254352	20/113 (18%)
		Ig	25..116	CDD:299845	20/110 (18%)
		Ig2_KIRREL3-like	138..219	CDD:143236	9/80 (11%)
		I-set	223..304	CDD:254352	20/91 (22%)
		Ig_2	227..305	CDD:290606	21/88 (24%)
		Ig_2	311..405	CDD:290606	28/108 (26%)
		IG_like	314..405	CDD:214653	28/105 (27%)
		Ig5_KIRREL3	407..504	CDD:143306	24/102 (24%)
		IG_like	416..504	CDD:214653	20/91 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810