DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bdl and tutl

DIOPT Version :9

Sequence 1:	NP_608822.1	Gene:	bdl / 33635	FlyBaseID:	FBgn0028482	Length:	719	Species:	Drosophila melanogaster
Sequence 2:	NP_001303307.1	Gene:	tutl / 46015	FlyBaseID:	FBgn0010473	Length:	1536	Species:	Drosophila melanogaster

Alignment Length:	826	Identity:	252/826 - (30%)
Similarity:	390/826 - (47%)	Gaps:	158/826 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPAKRSR------TFRQSGSALLALLAIILLMNISCTSAARDHRRQTNLEAKVGSHVVFNCYIDF 59
            :|.:|.:      |.:.....|::||| :|..|....:...|   ..::.|.:|..|:|||:::|
  Fly    94 VPIRRGQGSTPTPTIQVLQFVLVSLLA-LLAKNAQAHNIPED---AVHITAILGEGVIFNCHVEF 154

  Fly    60 PFDAPIPYLVHWTK------DNKKIFTWYEQ-ETSTSELFNGRLHLVENHPEFGRASVNLTAIRE 117
            |.|.|:||::.|.|      .:..|:.|||. .....|.:.||:..|.....||.||:|||.|||
  Fly   155 PNDHPVPYVLQWDKKVSETGSDLPIYIWYESYPEHIEEGYKGRVSRVSQDSPFGSASLNLTNIRE 219

  Fly   118 SDQGWYHCQVSFPNRSPSVRNNGTAYHLAVQ---------------------------------- 148
            ||||||.|:|.|.||.|....|||.:||.|.
  Fly   220 SDQGWYECKVVFLNRDPKQHKNGTWFHLDVHAPPRFSVTPEDIIYVNLGDSIILNCQADGTPTPE 284

  Fly   149 ----------------------------------------------------------GGSLIRI 155
                                                                      ||::|.:
  Fly   285 ILWYKDANPVDPSPTVGIFNDGTELRISTIRHEDIGEYTCIARNGEGQVSHTARVIIAGGAVIMV 349

  Fly   156 PPVNQTIREGQTAFFHCVMK-HPENSQASWYKDGVLLQEVQDLVRRFYMGPDGSLSIDPTMMSDL 219
            ||.|||..||:...|.|..| .|.|....||::|..::||..|..|..:..||||.|:|....|.
  Fly   350 PPTNQTKLEGEKVIFSCEAKAMPGNVTVRWYREGSPVREVAALETRVTIRKDGSLIINPIKPDDS 414

  Fly   220 GEYECKVRNSDGELQTAKAFLNIQYKAKVIYAPPEVFLPYGQPAVLDCHFRANPPLKNLRWEKDG 284
            |:|.|:|.|..|:.|:|.|:|:::|.|||.:.|...:||:....|:.|:.:::|.|:.:.|.||.
  Fly   415 GQYLCEVTNGIGDPQSASAYLSVEYPAKVTFTPTVQYLPFRLAGVVQCYIKSSPQLQYVTWTKDK 479

  Fly   285 LLFDSYNVPGVFYKMNGSLFFAKVDENHAGSYTCTPYNDLGTDGPSPVISVIVLRPPIFSVTPKA 349
            .|.:.|.:..:....||||.|.:|:|.|.|.|.|||||..||.|.|.|:.|:|.:||.|:|.|:.
  Fly   480 RLLEPYQMKDIVVMANGSLLFTRVNEEHQGQYACTPYNAQGTAGASGVMDVLVRKPPAFTVEPET 544

  Fly   350 IYIQKLGEAAELPCEAIDRDGNNRPSIIWGRKDGQPL---PADRFSLSGGNLTITGLVEGDRGIY 411
            :|.:|:|::.|:.|:|::.:|..||:|.|.|::|:.|   ..:|..:||||:||..|...|.|.|
  Fly   545 LYQRKVGDSVEMHCDALEAEGTERPTIKWQRQEGEQLTESQRNRIKISGGNITIENLRREDFGYY 609

  Fly   412 ECSATNEAATITAEAELMIENIAPRAPYNLTANSTETCITIRWQPGY---LRPNLEYTVWYRLME 473
            :|..:||.||:.|..:|:||...|.||||:|..:||:.||::|.|||   .....:||:|:|...
  Fly   610 QCVVSNEVATLMAVTQLVIEGTQPHAPYNITGKATESSITLQWLPGYSGGSEYKQDYTIWFREAG 674

  Fly   474 APEWRTLRVLDKKVMEATVQHLQPGKEYEFMVLSQDKYGDGMFSKQFRFQTL------PSPIRA- 531
            ..:|:|:.|......:.|:..|..|..|||.|:.::..||||.||....:||      |..::|
  Fly   675 VNDWQTISVTPSGSTQVTINGLASGTTYEFQVVGRNVLGDGMMSKVMTVRTLEDAPAAPRNVKAA 739

  Fly   532 ----DDF------DAQQLQH-DLGQVTAPAGGL--------------GAPWNLTAISNQQGWLLH 571
                |.|      :|..|.: |:...|...|.|              |.|.|::......|:|:.
  Fly   740 TQPPDSFFQLMPDEADLLAYFDIYFHTDSRGTLVYSPPKLRVKGPKPGPPRNVSVTEVSNGFLIT 804

  Fly   572 WEHPVQGLEGLRLYAVRW-----WKEPEHFLIGHAETFDNYYQLRHLKEDTLFKVQVLAVGTETQ 631
            |:.|::....::.|.:::     ||......|...||   .|.:::|.....:..:|||...::.
  Fly   805 WQSPLERAHIVKFYTIKYRTDAQWKTLNRGQIRPEET---QYLVKNLVGGRTYYFRVLANSEKSY 866

  Fly   632 QSVPSHELLIDVPSQRKVRALIIGSSVGVIFLLCALCAFLYVKRSC 677
            :|  |.|:...||::.|.:|:..|...|::|.:.|:...:...:.|
  Fly   867 ES--SDEVKFPVPARVKHKAITAGVVGGILFFIVAIILSVCAVKIC 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bdl	NP_608822.1	IG_like	42..128	CDD:214653	39/92 (42%)
		Ig	43..131	CDD:299845	41/94 (44%)
		I-set	153..242	CDD:254352	37/89 (42%)
		Ig	157..242	CDD:299845	35/85 (41%)
		Ig_2	252..337	CDD:290606	33/84 (39%)
		IG_like	260..327	CDD:214653	25/66 (38%)
		I-set	341..428	CDD:254352	35/89 (39%)
		IGc2	356..419	CDD:197706	25/65 (38%)
		FN3	435..524	CDD:238020	34/91 (37%)
		FN3	554..636	CDD:238020	19/86 (22%)
tutl	NP_001303307.1	V-set	137..250	CDD:284989	49/112 (44%)
		IG_like	137..229	CDD:214653	39/91 (43%)
		I-set	253..341	CDD:254352	0/87 (0%)
		IGc2	268..331	CDD:197706	0/62 (0%)
		I-set	346..437	CDD:254352	37/90 (41%)
		Ig	349..437	CDD:299845	36/87 (41%)
		Ig	459..530	CDD:299845	29/70 (41%)
		IG_like	549..628	CDD:214653	31/78 (40%)
		IGc2	551..617	CDD:197706	25/65 (38%)
		FN3	633..725	CDD:238020	34/91 (37%)
		FN3	786..874	CDD:238020	21/92 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	86	1.000	Domainoid score	I8036
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D151368at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14609
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10075
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.920