DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bdl and LSAMP

DIOPT Version :9

Sequence 1:	NP_608822.1	Gene:	bdl / 33635	FlyBaseID:	FBgn0028482	Length:	719	Species:	Drosophila melanogaster
Sequence 2:	NP_001305844.1	Gene:	LSAMP / 4045	HGNCID:	6705	Length:	361	Species:	Homo sapiens

Alignment Length:	322	Identity:	76/322 - (23%)
Similarity:	133/322 - (41%)	Gaps:	46/322 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 NQTIREGQTAFFHCVMKHPENSQASWY-KDGVL--------LQEVQDLVRRFYMGPDGSLSIDPT 214
            |.|:|:|.||...||:: .:||:.:|. :.|::        |....:|.:|..:  :.||.|...
Human    40 NITVRQGDTAILRCVVE-DKNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSL--EYSLRIQKV 101

  Fly   215 MMSDLGEYECKVRNSDGELQTAKAFLNIQYKAKVIYAPPEVFLPYGQPAVLDCHFRANP-PLKNL 278
            .:.|.|.|.|.|: :..|.:|::.:|.:|...|:.....:|.:..|....|.|.....| |:  :
Human   102 DVYDEGSYTCSVQ-TQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMANGRPEPV--I 163

  Fly   279 RWE---KDGLLFDSYNVPGVFYKMNGSLFFAKVDENHAGSYTCTPYNDLGTDGPSPVISVIVLRP 340
            .|.   ..|..|:...   .:.::.|      :....:|.|.|...|::.:.....| .|.|..|
Human   164 TWRHLTPTGREFEGEE---EYLEILG------ITREQSGKYECKAANEVSSADVKQV-KVTVNYP 218

  Fly   341 PIFSVTPKAIYIQKLGEAAELPCEAIDRDGNNRPSIIWGRKDGQPLPADRFSLSG----GNLTIT 401
            |  ::|.........|..|.|.|||   .....|...|.|.|.:...|:...:..    .:||:|
Human   219 P--TITESKSNEATTGRQASLKCEA---SAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVT 278

  Fly   402 GLVEGDRGIYECSATNEAATITAEAELMIENIAPRAPYNLTANSTETCITIRWQ---PGYLR 460
            .:.|...|.|.|.|.|:.. :|..:.::.:.:.|..|:.:....|    |:.::   ||.:|
Human   279 NVTEEHYGNYTCVAANKLG-VTNASLVLFKRVLPTIPHPIQEIGT----TVHFKQKGPGSVR 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bdl	NP_608822.1	IG_like	42..128	CDD:214653
		Ig	43..131	CDD:299845
		I-set	153..242	CDD:254352	26/91 (29%)
		Ig	157..242	CDD:299845	26/91 (29%)
		Ig_2	252..337	CDD:290606	16/88 (18%)
		IG_like	260..327	CDD:214653	13/70 (19%)
		I-set	341..428	CDD:254352	23/90 (26%)
		IGc2	356..419	CDD:197706	20/66 (30%)
		FN3	435..524	CDD:238020	7/29 (24%)
		FN3	554..636	CDD:238020
LSAMP	NP_001305844.1	Ig	38..128	CDD:386229	26/91 (29%)
		Ig	132..215	CDD:386229	17/94 (18%)
		Ig_3	219..294	CDD:372822	21/79 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810