DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bdl and dscamb

DIOPT Version :9

Sequence 1:	NP_608822.1	Gene:	bdl / 33635	FlyBaseID:	FBgn0028482	Length:	719	Species:	Drosophila melanogaster
Sequence 2:	XP_009289749.1	Gene:	dscamb / 386937	ZFINID:	ZDB-GENE-031118-67	Length:	2020	Species:	Danio rerio

Alignment Length:	729	Identity:	176/729 - (24%)
Similarity:	272/729 - (37%)	Gaps:	202/729 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 CYIDFPFDAPIPYLVHWTKDNKKIFTWYEQETSTSELFNGRLHLVENHPEFGRASVNLTAIRESD 119
            |::.   ..|:| .|.||.|:..:.     :.|...:  .|:...|.|.   .:.:|::..:.||
Zfish   428 CHVK---GTPLP-TVTWTLDDDPVI-----KDSNHRM--DRIITTEGHV---LSYLNVSHTQVSD 478

  Fly   120 QGWYHCQVSFPNRSPSVRNNGTAYHLAVQGGSLIRIPPVNQTIREGQTAFFHC-VMKHPENSQAS 183
            .|.|.|..:  |.:.||....   .:.|:|.:.|| |..|.|...|:..:.|| ::.:|..| ..
Zfish   479 GGVYRCTCN--NSAGSVSYQA---RINVRGPASIR-PMKNVTAIAGRDTYIHCRIIGYPYYS-IK 536

  Fly   184 WYKDGVLLQEVQDLVRRFYMGPDGSLSIDPTMMSDLGEYECKVRNSDGELQTAKAFLNIQYKAKV 248
            ||||..||....   |:.....:|:|.:.....||.|||.|.|. .|.|.|..:   ::....||
Zfish   537 WYKDSNLLPFNH---RQRAFENNGTLKLSNVQNSDEGEYTCYVL-VDPEKQIHR---SVHVTVKV 594

  Fly   249 IYAPPEV------FLPYGQPAVLDCHFRANPPLKNLRWEKD--------GLLFDSYNVPGVFYKM 299
               ||.:      ....||...:.|...:.....::.|.||        |:..|:.:       .
Zfish   595 ---PPLIQHSDSQSASIGQRVFIPCVVISGDLPMSITWHKDGRPINASLGVTIDNID-------F 649

  Fly   300 NGSLFFAKVDENHAGSYTCTPYNDLGTDGPSPVISVIVLRPPIFSVTPK---AIYIQKLGEAAEL 361
            ..||..:.:.|.|.|||||...|:......|  |.:||..||.|.|.||   .||    |::..|
Zfish   650 TSSLRISNLSEIHNGSYTCIARNEAAAVEHS--IQLIVKVPPHFEVQPKDQDGIY----GKSVTL 708

  Fly   362 PCEAIDRDGNNRPSIIWGRKDG------QPLPADRFS----LSGGNLTITGLVEGDRGIYECSAT 416
            .|.|   .||..|:|:|....|      ||:..:..|    |..|:|.|..::|.|.|.|.|..:
Zfish   709 NCSA---KGNPIPTIVWNHSKGAGVPQFQPIALNSGSRVQLLENGSLLIKHVLEEDAGFYLCKVS 770

  Fly   417 NE-AATITAEAELMIENIAPRAPYNLTANSTE------TC-------ITIRW--QPGYLRPNL-E 464
            |: .|.|:....|.::..|....|..|..:.:      :|       |.:||  :...:.|:: .
Zfish   771 NDVGADISKSMYLTVKIPAMITSYPNTTRAEQGHMTEMSCTAHGEKPIKVRWEKESHIINPDMSR 835

  Fly   465 YTVWYRLMEAPEWRTLRVLDKKVMEATVQHLQPGKEYE--FMVLSQDKYGDGMFSKQFRFQTLP- 526
            |.|           |::.:..:|: :|:|.|...:|..  |..::.:.||:.....|...|..|
Zfish   836 YVV-----------TVKEVGDEVI-STLQILHTVREDSGFFSCIAINSYGEDKGIIQLIVQDRPD 888

  Fly   527 -------------------------SPIRADDFD---------AQQLQHD----LGQVT------ 547
                                     |||...|.:         :.|:..|    |.|.|
Zfish   889 PPEVEIREVKDRTIALRWTMGFDGNSPITGYDINYKNKSASWASSQMTKDVSPQLNQATIIELHP 953

  Fly   548 -----------------------------APAGGLGAPWNLTAISNQQGWLLHWEHPVQGLEG-- 581
                                         ||..|......|.|||: ||..:.|:.|.:.|:.
Zfish   954 ASTYNIRMFAKNQIGESRPSNELTITTDEAPPDGAPQDVQLEAISS-QGIKVTWKPPHKHLQNGL 1017

  Fly   582 LRLYAVRWWK-----EPEHFLI-----GHAETFDNYYQLRHLKEDTLFKVQVLAVGTETQQSVPS 636
            :|.|.|.:.:     .|::..|     |..||.    .|.:||:.|.::|:|.| .........|
Zfish  1018 IRSYQVCYREFGTGGSPQYNTINVDTTGDIETL----TLDNLKKYTQYEVRVQA-ANRAGMGPTS 1077

  Fly   637 HELLI----DVPSQ 646
            .|:.|    ||||:
Zfish  1078 EEITITTLEDVPSR 1091

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bdl	NP_608822.1	IG_like	42..128	CDD:214653	17/72 (24%)
		Ig	43..131	CDD:299845	17/75 (23%)
		I-set	153..242	CDD:254352	29/89 (33%)
		Ig	157..242	CDD:299845	26/85 (31%)
		Ig_2	252..337	CDD:290606	22/98 (22%)
		IG_like	260..327	CDD:214653	18/74 (24%)
		I-set	341..428	CDD:254352	32/100 (32%)
		IGc2	356..419	CDD:197706	23/73 (32%)
		FN3	435..524	CDD:238020	19/106 (18%)
		FN3	554..636	CDD:238020	24/93 (26%)
dscamb	XP_009289749.1	I-set	132..198	CDD:254352
		I-set	225..310	CDD:254352
		IGc2	239..300	CDD:197706
		IG_like	320..400	CDD:214653
		IGc2	328..391	CDD:197706
		IG_like	417..501	CDD:214653	20/91 (22%)
		Ig	424..498	CDD:143165	20/88 (23%)
		IG_like	511..592	CDD:214653	26/88 (30%)
		IGc2	518..576	CDD:197706	20/61 (33%)
		I-set	595..685	CDD:254352	22/98 (22%)
		Ig	612..682	CDD:143165	17/78 (22%)
		I-set	689..785	CDD:254352	33/102 (32%)
		Ig7_DSCAM	706..785	CDD:143211	25/81 (31%)
		IG_like	795..883	CDD:214653	18/99 (18%)
		Ig	803..890	CDD:299845	19/98 (19%)
		FN3	887..980	CDD:238020	10/92 (11%)
		FN3	987..1084	CDD:238020	28/102 (27%)
		FN3	1092..1185	CDD:238020	176/729 (24%)
		FN3	1190..1279	CDD:238020
		IGc2	1302..1367	CDD:197706
		FN3	1398..1471	CDD:238020
		FN3	1485..1557	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10075
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910