DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bdl and Sdk2

DIOPT Version :9

Sequence 1:	NP_608822.1	Gene:	bdl / 33635	FlyBaseID:	FBgn0028482	Length:	719	Species:	Drosophila melanogaster
Sequence 2:	XP_006247755.1	Gene:	Sdk2 / 360652	RGDID:	1310397	Length:	2175	Species:	Rattus norvegicus

Alignment Length:	637	Identity:	149/637 - (23%)
Similarity:	228/637 - (35%)	Gaps:	113/637 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 PFDAPIPYLVHWTKDNKKIFTWYEQETSTSE-----LFNGR----LHLV---------ENHPEFG 106
            |.|...|.::...|:...:       ..|||     :.|.|    ||:|         ....::.
  Rat   212 PADPIAPTIIIPPKNTSVV-------AGTSEVTMECVANARPLIKLHIVWKKDGALLSNGISDYN 269

  Fly   107 RASVNLTAIRESDQGWYHCQVSFPNRSPSVRNNGTAYHLAVQGGSLIRIPPVNQTIREGQTAFFH 171
            | .:.:|....||.|:|.|:....:.|.:....| ||...::....:|.|..:.|....:.....
  Rat   270 R-RLTITNPMVSDAGYYECEAMLRSSSVAPVTRG-AYLSVLEPPQFVREPERHITAEMEKVVDIP 332

  Fly   172 CVMKHPENSQASWYKDGVLLQEVQDLVRRFYMGPDGSLSIDPTMMSDLGEYECKVRNSDGELQTA 236
            |..|.......:||||..|: ||..|. ||....||.|.|...:..|.|..:|...|:.||.||:
  Rat   333 CRAKGVPPPSITWYKDAALV-EVGKLT-RFKQRSDGGLQISGLLPDDTGMVQCFAHNAAGEAQTS 395

  Fly   237 KAFLNIQYKAKVIYAPPEVFLPYGQPAVLDCHFRANPPLKNLRWEKDG--LLFDSYNVPGVFYKM 299
            ...........:...|.:..:..|...||.|. .:..|...:.|:|..  |...|..:|......
  Rat   396 TYLAVTSIAPNITRGPLDSTVIDGMSVVLACE-TSGAPRPAITWQKGERILASGSVQLPRFTLLE 459

  Fly   300 NGSLFFAKVDENHAGSYTCTPYNDLGTDGPSPVISV----IVLRPPIFSVTPKAIYIQKLGEAAE 360
            :|||..:....:.||:|||...|..|.|..|..:.|    .:.:||......|       |..|.
  Rat   460 SGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIK-------GTQAS 517

  Fly   361 LPCEAIDRDGNNRPSIIWGRKDGQPLPAD---RFSLS-GGNLTITGLVEGDRGIYECSATNEAAT 421
            :.| .:..|.......:| .|||..|..:   |..|. .|:|.|:....||.|.|.|...:....
  Rat   518 MVC-GVTHDPRVTVRYVW-EKDGATLAVETNPRIRLDRNGSLHISQTWSGDIGTYTCRVLSAGGN 580

  Fly   422 ITAEAELMIENI--APRAPYNLTANSTETCITIRWQPGY--LRPNLEYTVWYRLMEAPEWRTLRV 482
            .:..|.|.:..:  ||..|....:......|.:.|...:  ..|.:.|.:......||....|..
  Rat   581 DSRNAHLRVRQLPHAPEHPVATLSTMERRAINLTWAKPFDGNSPLMRYILEMSENNAPWTILLAS 645

  Fly   483 LDKKVMEATVQHLQPGKEYEFMVLSQDKYGDGMFSKQFRFQTLPSPIRADDFDAQQLQHDLGQVT 547
            :|.:.....|:.|.|.:.|:|.:.:.:..|.|.|||.....:||..                ..|
  Rat   646 VDPEATSVMVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEE----------------PPT 694

  Fly   548 APAGGLGAPWNLTAIS-NQQGWLLHWEHPVQGLEG--LRLYAVRWWKEPEHFLIGHAETFDNYYQ 609
            ||      |.|:.|.. ..|..::.|:.|.:..:.  |:.|.:|      :.|.|    ....||
  Rat   695 AP------PQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIR------YCLAG----LPVGYQ 743

  Fly   610 LRH---------LKED----TLFKVQVLAVG-----------TE-TQQSVPS 636
            .::         |.||    |.::::|.|..           || |.|.||:
  Rat   744 FKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPT 795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bdl	NP_608822.1	IG_like	42..128	CDD:214653	19/85 (22%)
		Ig	43..131	CDD:299845	19/88 (22%)
		I-set	153..242	CDD:254352	27/88 (31%)
		Ig	157..242	CDD:299845	25/84 (30%)
		Ig_2	252..337	CDD:290606	24/90 (27%)
		IG_like	260..327	CDD:214653	20/68 (29%)
		I-set	341..428	CDD:254352	22/90 (24%)
		IGc2	356..419	CDD:197706	19/66 (29%)
		FN3	435..524	CDD:238020	20/90 (22%)
		FN3	554..636	CDD:238020	24/109 (22%)
Sdk2	XP_006247755.1	IG_like	43..112	CDD:214653
		IGc2	43..101	CDD:197706
		IG_like	123..206	CDD:214653
		Ig	135..191	CDD:299845
		IG_like	225..307	CDD:214653	20/90 (22%)
		IGc2	236..289	CDD:197706	12/53 (23%)
		I-set	311..400	CDD:254352	27/90 (30%)
		Ig	329..397	CDD:143165	24/69 (35%)
		I-set	405..495	CDD:254352	23/90 (26%)
		Ig	419..495	CDD:299845	22/76 (29%)
		Ig	505..589	CDD:299845	23/92 (25%)
		IG_like	505..589	CDD:214653	23/92 (25%)
		FN3	593..684	CDD:238020	21/90 (23%)
		FN3	696..789	CDD:238020	22/108 (20%)
		FN3	797..893	CDD:238020
		FN3	898..986	CDD:238020
		FN3	996..1090	CDD:238020
		FN3	1102..1197	CDD:238020
		FN3	1204..1293	CDD:238020
		FN3	1304..1397	CDD:238020
		FN3	1403..1487	CDD:238020
		FN3	1506..1619	CDD:238020
		FN3	1629..1722	CDD:238020
		FN3	1727..1808	CDD:238020
		FN3	1840..1919	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900