DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bdl and Dscam1

DIOPT Version :9

Sequence 1:	NP_608822.1	Gene:	bdl / 33635	FlyBaseID:	FBgn0028482	Length:	719	Species:	Drosophila melanogaster
Sequence 2:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster

Alignment Length:	802	Identity:	156/802 - (19%)
Similarity:	271/802 - (33%)	Gaps:	282/802 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 RQTNLEAKV-GSHVVFNCYI-DFPFDAPIPYLVHWTKDNK--------KIFTWYEQETSTSELFN 93
            ||...:|.| |..::..|.: .:|.|:     :.|.:||:        |:|.            |
  Fly   534 RQMEKKAIVAGETLIVTCPVAGYPIDS-----IVWERDNRALPINRKQKVFP------------N 581

  Fly    94 GRLHLVENHPEFGRASVNLTAIRESDQGW--------------------------------YHCQ 126
            |.| ::|| .|........|.:.::.:|:                                ..||
  Fly   582 GTL-IIEN-VERNSDQATYTCVAKNQEGYSARGSLEVQVMVLPQIVPFAYEDLINMGDSIDLFCQ 644

  Fly   127 V--------------------SFPNRSPSVRNNGTAYHLAVQGGSLIRIP--------------- 156
            :                    .|....|.:|.|..:     :..|:|.||
  Fly   645 IQKGDRPIKVHWSFERSAGDYGFDQVQPQMRTNRIS-----EKTSMISIPSASPAHTGRDTCIAS 704

  Fly   157 -----------------------PVNQTIREGQTAFFHCVMKHPENSQASWYKD-GVLLQEVQDL 197
                                   |.::...:|..|...|........|.:|.|. |....|.:||
  Fly   705 NKAGTTTYSVDLTVNVPPRWILEPTDKAFAQGSDAKVECKADGFPKPQVTWKKAVGDTPGEYKDL 769

  Fly   198 VRRFYMG-PDGSLSIDPTMMSDLGEYECKVRNSDGELQTAKAFLNIQYKAKVIYAPPEV------ 255
            .:...:. .:|:|.:|....::.|.|.|:..|..|...:|...:::|       ||||.
  Fly   770 KKSDNIRVEEGTLHVDNIQKTNEGYYLCEAINGIGSGLSAVIMISVQ-------APPEFTEKLRN 827

  Fly   256 -FLPYGQPAVLDCHFRANPPLKNLRWEKDGLLFDSYN-----------VPGVFYKMNGSLFFAKV 308
             ....|:||||.|..:...|: .:.|..:.:..|..|           ..||.    .||...:.
  Fly   828 QTARRGEPAVLQCEAKGEKPI-GILWNMNNMRLDPKNDNRYTIREEILSTGVM----SSLSIKRT 887

  Fly   309 DENHAGSYTCTPYNDLGTDGPSPVISVIVLRPPIFSVTPKAIYIQKLGEAAELP--CEAIDRDGN 371
            :.:.:..:||...|..|:|..|  |::||...|                  |:|  .:.:|:.|.
  Fly   888 ERSDSALFTCVATNAFGSDDAS--INMIVQEVP------------------EMPYALKVLDKSGR 932

  Fly   372 NRPSIIWGRK-DGQPLPADRFSLSGGNLTITGLVEGDRGIYECSATNEAATITAEAELMIENIAP 435
            : ..:.|.:. ||.. |.||:           ::|..|.....|..:.........|..::.::|
  Fly   933 S-VQLSWAQPYDGNS-PLDRY-----------IIEFKRSRASWSEIDRVIVPGHTTEAQVQKLSP 984

  Fly   436 RAPYNL---------TANSTE-------------------------TCITIRWQPGYLRPNLE-- 464
            ...||:         |:.|:|                         |.:.:.|:|   .|..|
  Fly   985 ATTYNIRIVAENAIGTSQSSEAVTIITAEEAPSGKPQNIKVEPVNQTTMRVTWKP---PPRTEWN 1046

  Fly   465 -----YTVWYRLMEAPE---WRTLRVLDKKVME--ATVQHLQPGKEYEFMVLSQDKYGDGMFS-- 517
                 |.|.|:|.....   :.|:..:.::..|  ..:|:|:...:|..::.:.:|.|.|..|
  Fly  1047 GEILGYYVGYKLSNTNSSYVFETINFITEEGKEHNLELQNLRVYTQYSVVIQAFNKIGAGPLSEE 1111

  Fly   518 -KQFRFQTLPSPIRADDFDAQQLQHDLGQVTAPAGGLGAPWNLTAISNQQGWLLHWEHPVQGLEG 581
             |||..:..||...:|.                     |...||:.:.:.||:   ..|::...|
  Fly  1112 EKQFTAEGTPSQPPSDT---------------------ACTTLTSQTIRVGWV---SPPLESANG 1152

  Fly   582 -LRLYAV------RWWKEPEHFLIGHAETFDNYYQLRHLKEDTLFKVQVLA--VGTETQQSVPSH 637
             ::.|.|      .|:.|.:..   :.:|..:...|..||:.|.:.:||||  .|.:..:|||.|
  Fly  1153 VIKTYKVVYAPSDEWYDETKRH---YKKTASSDTVLHGLKKYTNYTMQVLATTAGGDGVRSVPIH 1214

  Fly   638 -ELLIDVP-SQRKVRALIIGSS 657
             :...||| :...|:||::|::
  Fly  1215 CQTEPDVPEAPTDVKALVMGNA 1236

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bdl	NP_608822.1	IG_like	42..128	CDD:214653	21/147 (14%)
		Ig	43..131	CDD:299845	22/149 (15%)
		I-set	153..242	CDD:254352	23/128 (18%)
		Ig	157..242	CDD:299845	20/86 (23%)
		Ig_2	252..337	CDD:290606	24/102 (24%)
		IG_like	260..327	CDD:214653	18/77 (23%)
		I-set	341..428	CDD:254352	14/89 (16%)
		IGc2	356..419	CDD:197706	13/65 (20%)
		FN3	435..524	CDD:238020	27/137 (20%)
		FN3	554..636	CDD:238020	23/90 (26%)
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845
		IG	57..133	CDD:214652
		IG_like	267..343	CDD:214653
		Ig	269..340	CDD:143165
		IG_like	353..425	CDD:214653
		IGc2	361..413	CDD:197706
		I-set	433..527	CDD:254352
		IGc2	446..517	CDD:197706
		I-set	533..618	CDD:254352	21/102 (21%)
		IGc2	544..607	CDD:197706	16/81 (20%)
		Ig	641..714	CDD:143165	10/77 (13%)
		IGc2	735..804	CDD:197706	17/68 (25%)
		I-set	819..914	CDD:254352	23/101 (23%)
		Ig	833..921	CDD:299845	25/112 (22%)
		FN3	918..1011	CDD:238020	21/123 (17%)
		FN3	1018..1116	CDD:238020	20/100 (20%)
		FN3	1124..1217	CDD:238020	26/119 (22%)
		FN3	1222..1312	CDD:238020	5/15 (33%)
		Ig	1339..1406	CDD:299845
		FN3	1409..1499	CDD:238020
		FN3	1504..1584	CDD:238020
		Dscam_C	1890..2008	CDD:289151
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10075
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910