DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bdl and itgb4

DIOPT Version :9

Sequence 1:	NP_608822.1	Gene:	bdl / 33635	FlyBaseID:	FBgn0028482	Length:	719	Species:	Drosophila melanogaster
Sequence 2:	XP_005166847.1	Gene:	itgb4 / 335269	ZFINID:	ZDB-GENE-030131-7209	Length:	1931	Species:	Danio rerio

Alignment Length:	658	Identity:	129/658 - (19%)
Similarity:	212/658 - (32%)	Gaps:	243/658 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 IDFP-----FDAPIPYLVHWTKDNKKIFTWYEQETSTSELFNGRLHLVENHPEFGRASVNLTAIR 116
            ::||     .|..:|..:....|.||            ||....:.:.....:.|:..||:|.::
Zfish   934 VEFPENVESVDVRVPLFIKDEDDEKK------------ELLVQAVDVPVGIAKIGKDHVNITVLK 986

  Fly   117 ESDQGWYHCQVS--FPNRSPSVRNNGTAYHLAVQGGSLIRIPPVNQTIREGQTAFFHCVMKHPEN 179
            |        |.|  |....||       |..:.|.| :..||...|.|.:|:
Zfish   987 E--------QASSVFTFLEPS-------YTYSRQDG-VANIPIKRQIIEDGR------------- 1022

  Fly   180 SQASWYKDGVLLQEVQDLVRRFYMGPDGSLS--------IDPTMMSDLGEYECKVRNSDGELQ-- 234
            :|.::....:..::.:|     |:..||.||        |.|..:.:|||       .||.|:
Zfish  1023 AQVTYSTADLTAKDKKD-----YISVDGDLSYGAGETEKIVPVKLLELGE-------QDGLLEDK 1075

  Fly   235 TAKAFL----NIQYKAKVIYAPPEVFLPYGQPAVLDCHFRANPPLKNLRWEKDGLLFDS----YN 291
            ..|.|:    |.:..||:...|..|.      .:.|     .|....:.::|....|.:    |.
Zfish  1076 QVKQFVMDLTNPRQSAKLGRYPRTVI------TIAD-----KPESSVMAFKKSTQTFSTTDSLYT 1129

  Fly   292 VP-----------GVFYKMNGSLFFAKVDENHAGSYTCTPYNDLGTD---GPSPVISVIVLRPPI 342
            :|           .|.::.|.:..|                 |:.:.   .|......|::.|
Zfish  1130 IPVERTGNRETPATVHWRTNKASRF-----------------DISSPLKFAPGEAEKNILINP-- 1175

  Fly   343 FSVTPKAIYIQKLGEAAELPCEAIDRDGNNRPSIIWGRKDGQPLPADRFSLSGGN--------LT 399
             ...|..|..:|..      .|.:|...|   :||..||..:.:..|... .|.|        :|
Zfish  1176 -RTHPSPIIPEKFN------LELLDPSNN---AIIGKRKTTEVIVTDGRG-DGKNQDFQKMEYVT 1229

  Fly   400 ITGLVEGDRGIYECSATNEAATITAEAELMIENIAPRAPYNLTANSTETCITIRWQPGYLRPNLE 464
            .|....|.| :|  |..|..|..|             .|.|:..|         |:|.   .|..
Zfish  1230 QTATSPGGR-LY--SPANIKAVAT-------------GPKNIRLN---------WKPS---QNAN 1266

  Fly   465 -YTVWYRLMEAPEWRTLRVLDKKVMEATVQHLQPGKEYEFMVLSQDKYGDGMFSKQFRFQTLPSP 528
             |.|.|.:...||.:. :.:|.|..:|.:.:|.|..:||..|...:..|||.:|...:.|||
Zfish  1267 GYKVKYWIYGDPEDKA-KFMDVKTPQAELTNLDPYCDYEMRVCGYNALGDGNYSDIIQCQTL--- 1327

  Fly   529 IRADDFDAQQLQHDLGQVTAPAGGLGAPWNLTAISNQQGWLLHWEHPVQGLEGLRLYAVRWWKEP 593
                    :.:..:.|::   |..:.:| .:|.:|        |..|.               |.
Zfish  1328 --------EDIPGEPGRL---AFNVISP-TVTQVS--------WAEPA---------------EA 1357

  Fly   594 EHFLIGHAETFDNYYQLRHLKEDTLFKVQVLAVGTETQQSVPSHELLIDVPSQR----------- 647
            ...:.|                   ::|..:.:..:.:.:.|..:::||.|.:|
Zfish  1358 NGIITG-------------------YEVIYMPINEDKKPTGPPKKVMIDNPKKRMLLIENLQPSQ 1403

  Fly   648 ----KVRA 651
                ||||
Zfish  1404 TYCYKVRA 1411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bdl	NP_608822.1	IG_like	42..128	CDD:214653	15/75 (20%)
		Ig	43..131	CDD:299845	17/80 (21%)
		I-set	153..242	CDD:254352	22/102 (22%)
		Ig	157..242	CDD:299845	20/98 (20%)
		Ig_2	252..337	CDD:290606	13/102 (13%)
		IG_like	260..327	CDD:214653	10/81 (12%)
		I-set	341..428	CDD:254352	22/94 (23%)
		IGc2	356..419	CDD:197706	17/70 (24%)
		FN3	435..524	CDD:238020	23/89 (26%)
		FN3	554..636	CDD:238020	8/81 (10%)
itgb4	XP_005166847.1	Integrin_beta	37..457	CDD:278776
		EGF_2	<468..490	CDD:285248
		EGF_2	545..573	CDD:285248
		Integrin_B_tail	625..709	CDD:285239
		Calx-beta	991..1064	CDD:295344	20/98 (20%)
		FN3	1242..1326	CDD:238020	26/109 (24%)
		FN3	1331..1420	CDD:238020	19/127 (15%)
		fn3	1640..1720	CDD:278470
		fn3	1751..1835	CDD:278470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900