DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bdl and Dscaml1

DIOPT Version :9

Sequence 1:	NP_608822.1	Gene:	bdl / 33635	FlyBaseID:	FBgn0028482	Length:	719	Species:	Drosophila melanogaster
Sequence 2:	NP_001101611.1	Gene:	Dscaml1 / 315615	RGDID:	1304887	Length:	2111	Species:	Rattus norvegicus

Alignment Length:	686	Identity:	162/686 - (23%)
Similarity:	253/686 - (36%)	Gaps:	147/686 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 RRQTNLEAKVGSHVVFNC-YIDFPFDAPIPYLVHWTKDNKKIFTWYEQETSTSELFNGRLHLVEN 101
            |...|:.|..|...:.|| .|.:|:     |.:.|.||                    .|.|.:|
  Rat   567 RAMRNITAVAGRDTLINCRVIGYPY-----YSIKWYKD--------------------ALLLPDN 606

  Fly   102 HPE--FGRASVNLTAIRES-DQGWYHCQVSF-PNRSPSVRNNGTAYHLAVQGGSLIR---IPPVN 159
            |.:  |...::.||.:::. |:|.|.|.|.. |..|.|     .:.|:||:...||:   .||.:
  Rat   607 HRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSIS-----QSVHVAVKVPPLIQPFEFPPAS 666

  Fly   160 QTIREGQTAFFHCVMKHPENS-QASWYKDG--VLLQEVQDLVRRFYMGPDGSLSIDPTMMSDLGE 221
                .||..:..||:...:.. :.:|.|||  ::......:..:.:|   .||.|....:...|.
  Rat   667 ----IGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFM---SSLQISSVSLKHNGN 724

  Fly   222 YECKVRNSDGELQTAKAFLNIQYKAKVIYAPPE-VFLP------YGQPAVLDCHFRANPPLKNLR 279
            |.|...|:...:...:..        ::..||. |..|      ||:..||:|.....||.| :.
  Rat   725 YTCIASNAAATVSRERQL--------IVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPK-VM 780

  Fly   280 WEK---DGLLFDSYNVP---GVFYKMNGSLFFAKVDENHAGSYTCTPYNDLGTDGPSPVISVIVL 338
            |:.   .|.....:.||   .:....|.||....|.|...|.|.|...|.:||| .|..:.:.|.
  Rat   781 WKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTD-ISKAMFLTVK 844

  Fly   339 RPPIFSVTPKAIYIQKLGEAAELPCEAIDRDGNNRPSIIWGRKDGQPLPADRF------SLSGGN 397
            .|.:.:..|......| |.|.||.|.|    ...||.||...|....:..||.      :...|:
  Rat   845 IPAMITSHPNTTIAIK-GHAKELNCTA----RGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGD 904

  Fly   398 LTITGLV-----EGDRGIYECSATNEAATITAEAELMIENIAPRAPYNLTANSTET-CITIRWQ- 455
            ..::.|.     .||...:.|.|.|.........:|.::.  |..|..|.....:. .:.:||.
  Rat   905 EVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQE--PPDPPELEIREVKARSMNLRWTQ 967

  Fly   456 --------PGYLRPNLEYTVWYRLMEAPEW---RTLRVLDKKVMEATVQHLQPGKEYEFMVLSQD 509
                    .|:   ::||.     .::..|   ::.|.:...:.:|.:..|.|...|...:.|.:
  Rat   968 RFDGNSIITGF---DIEYK-----NKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFN 1024

  Fly   510 KYGDGMFSKQFRFQTLPSPIRADDFDAQQLQHDLGQVTAPAGGLGAPWNLTAIS-NQQGWLLHWE 573
            |.|....||:....|                    :..||.   |.|.::|... ..|...:.|:
  Rat  1025 KIGRSEPSKELTIST--------------------EEAAPD---GPPMDVTLQPVTSQSIQVTWK 1066

  Fly   574 HPVQGLEG--LRLYAVRWWKEP-----EHFLIGHAETFDN-YYQLRHLKEDTLFKVQVLA---VG 627
            .|.:.|:.  :|.|.:.:.:..     ::.::....|.|: .|.|.:||:...:.|.|.|   .|
  Rat  1067 APKKELQNGIIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAG 1131

  Fly   628 TETQQSVPSHELLIDVPSQ--RKVRALIIGSSVGVI 661
            |....|..:...|.|||||  ..||||.|.|.|.||
  Rat  1132 TGPSSSEINATTLEDVPSQPPENVRALSITSDVAVI 1167

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bdl	NP_608822.1	IG_like	42..128	CDD:214653	22/89 (25%)
		Ig	43..131	CDD:299845	22/92 (24%)
		I-set	153..242	CDD:254352	19/94 (20%)
		Ig	157..242	CDD:299845	17/87 (20%)
		Ig_2	252..337	CDD:290606	29/97 (30%)
		IG_like	260..327	CDD:214653	21/72 (29%)
		I-set	341..428	CDD:254352	22/97 (23%)
		IGc2	356..419	CDD:197706	20/73 (27%)
		FN3	435..524	CDD:238020	19/101 (19%)
		FN3	554..636	CDD:238020	21/93 (23%)
Dscaml1	NP_001101611.1	IG	101..173	CDD:214652
		IGc2	101..168	CDD:197706
		Ig	183..276	CDD:299845
		IG_like	195..276	CDD:214653
		I-set	291..369	CDD:254352
		IGc2	298..359	CDD:197706
		IGc2	386..447	CDD:197706
		I-set	466..560	CDD:254352
		Ig	466..556	CDD:299845
		IGc2	577..635	CDD:197706	20/82 (24%)
		IG_like	665..744	CDD:214653	16/93 (17%)
		Ig	673..739	CDD:143165	14/68 (21%)
		I-set	748..843	CDD:254352	28/96 (29%)
		Ig7_DSCAM	765..843	CDD:143211	23/79 (29%)
		I-set	849..942	CDD:254352	23/97 (24%)
		Ig	861..949	CDD:299845	22/93 (24%)
		FN3	945..1039	CDD:238020	19/101 (19%)
		FN3	1046..1143	CDD:238020	21/96 (22%)
		fn3	1151..1237	CDD:278470	9/17 (53%)
		FN3	1249..1340	CDD:238020
		IGc2	1364..1428	CDD:197706
		FN3	1442..1532	CDD:238020
		FN3	1546..1618	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10075
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910