DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bdl and sdk

DIOPT Version :9

Sequence 1:	NP_608822.1	Gene:	bdl / 33635	FlyBaseID:	FBgn0028482	Length:	719	Species:	Drosophila melanogaster
Sequence 2:	NP_001284756.1	Gene:	sdk / 31017	FlyBaseID:	FBgn0021764	Length:	2265	Species:	Drosophila melanogaster

Alignment Length:	728	Identity:	150/728 - (20%)
Similarity:	255/728 - (35%)	Gaps:	197/728 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 RQTNLEAKVGSHVV-FNCYIDFPFDAPIPYL-VHWTKDNKKIFTWYEQETSTSELFNGRLHLVEN 101
            |..:::.|||:.|| ..|..:   ..|:..| ..|.||...:      ||:      |..|.: |
  Fly   266 RPQDVKVKVGTGVVELQCIAN---ARPLHELETLWLKDGLAV------ETA------GVRHTL-N 314

  Fly   102 HPEFGRASVNLTAIRESDQGWYHCQV-----SFPNRSPSVRNNGTAYHLAVQGGSLIRIPPVNQT 161
            .| :.|....|.| ..|..|.|.|||     .:|..|.|.|       |.:....|...|...:|
  Fly   315 DP-WNRTLALLQA-NSSHSGEYTCQVRLRSGGYPAVSASAR-------LQILEPPLFFTPMRAET 370

  Fly   162 IRE--GQTAFFHCVMKHPENSQASWYKDGVLLQEVQDLVR--RFYMGPDGSLSIDPTMMSDLGEY 222
            ..|  ||......|:..| ..|..|:::.   :.|...:.  |:.:..|.:|.|...::.|...:
  Fly   371 FGEFGGQVQLTCDVVGEP-TPQVKWFRNA---ESVDAHIESGRYTLNTDNTLVIKKLILDDAAMF 431

  Fly   223 ECKVRNSDGELQTAKAFLNIQYK------------------------------------------ 245
            :|...|..|| .:|..:|.::.|
  Fly   432 QCLAINEAGE-NSASTWLRVKTKTAKNRVKRLAQPRILRVRASHAGLGSEKGSESGSSDRRKEFR 495

  Fly   246 ---AKVIYAPPE-VFLPYGQPAVLDCHFRANPPLKNLRWEKDGLLFDSYNVPGVFYKM----NGS 302
               |.::..||: |....|:.|.:.|. ....|..|:.|     :::...:..:..::    :|.
  Fly   496 FASAPIMELPPQNVTALDGKDATISCR-AVGSPNPNITW-----IYNETQLVDISSRVQILESGD 554

  Fly   303 LFFAKVDENHAGSYTCTPYNDLGTDGPSPVISVIV----LRPPIFSVTPKAIYIQKLGEAAELPC 363
            |..:.:....||.|.|...|:.|:......:||:|    ::||:.:..       .||..|.|.|
  Fly   555 LLISNIRSVDAGLYICVRANEAGSVKGEAYLSVLVRTQIIQPPVDTTV-------LLGLTATLQC 612

  Fly   364 EAIDRDGNNRPSIIWGRKDGQPLPADRFSLSG----GNLTITGLVEGDRGIYECSATNEAATITA 424
            : :..|.:...:|.|.|:.....|.......|    |.|.|..:...|.|.|.|..|:.....|.
  Fly   613 K-VSSDPSVPYNIDWYREGQSSTPISNSQRIGVQADGQLEIQAVRASDVGSYACVVTSPGGNETR 676

  Fly   425 EAELMIENIAPRAPYNLTA----NSTETCITIRWQPGY--LRPNLEYTVWYR----LMEAPE--- 476
            .|.|.:..: |..|.|:..    ...:..|.:.|.||:  ..|..::.:..|    |...|:
  Fly   677 AARLSVIEL-PFPPSNVKVERLPEPQQRSINVSWTPGFDGNSPISKFIIQRREVSELGPVPDPLL 740

  Fly   477 -WRT-LRVLDKKVMEATVQHLQPGKEYEFMVLSQDKYGDGMFSKQFRFQTLPSPIRADDFDAQQL 539
             |.| |..:........:::|:....|:|.|.:.::.|:|..|:......||....:.
  Fly   741 NWITELSNVSADQRWILLENLKAATVYQFRVSAVNRVGEGSPSEPSNVVELPQEAPSG------- 798

  Fly   540 QHDLGQVTAPAGGLGAPWNLTAISNQQGWLLHWEHPVQGLEGLRL--YAVRW---------W--- 590
                    .|.|.:|:..:::.|..|      |:.|::.....::  |.:|:         |
  Fly   799 --------PPVGFVGSARSMSEIITQ------WQPPLEEHRNGQILGYILRYRLFGYNNVPWSYQ 849

  Fly   591 ----KEPEHFLIGHAETFDNYYQLRHLKEDTLFKVQVLA-----VGT-------ETQQSVPSHEL 639
                :...:|||....|:.:|.            ||:.|     ||.       :|::.||...
  Fly   850 NITNEAQRNFLIQELITWKDYI------------VQIAAYNNMGVGVYTEGSKIKTKEGVPEAP- 901

  Fly   640 LIDVPSQRKVRAL 652
                |:..||.|:
  Fly   902 ----PTNVKVEAI 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bdl	NP_608822.1	IG_like	42..128	CDD:214653	26/92 (28%)
		Ig	43..131	CDD:299845	26/94 (28%)
		I-set	153..242	CDD:254352	21/92 (23%)
		Ig	157..242	CDD:299845	20/88 (23%)
		Ig_2	252..337	CDD:290606	19/89 (21%)
		IG_like	260..327	CDD:214653	14/70 (20%)
		I-set	341..428	CDD:254352	22/90 (24%)
		IGc2	356..419	CDD:197706	18/66 (27%)
		FN3	435..524	CDD:238020	21/103 (20%)
		FN3	554..636	CDD:238020	20/111 (18%)
sdk	NP_001284756.1	Ig	71..157	CDD:299845
		I-set	72..150	CDD:254352
		Ig	172..245	CDD:299845
		IG_like	280..356	CDD:214653	26/100 (26%)
		Ig	280..343	CDD:299845	21/80 (26%)
		IG_like	375..450	CDD:214653	18/79 (23%)
		Ig	378..447	CDD:143165	15/73 (21%)
		Ig	506..587	CDD:299845	16/86 (19%)
		IG_like	506..587	CDD:214653	16/86 (19%)
		I-set	592..682	CDD:254352	24/97 (25%)
		Ig	595..682	CDD:299845	24/94 (26%)
		FN3	686..789	CDD:238020	21/102 (21%)
		FN3	798..893	CDD:238020	20/127 (16%)
		FN3	901..1005	CDD:238020	4/15 (27%)
		fn3	1011..1094	CDD:278470
		FN3	1108..1202	CDD:238020
		FN3	1210..1308	CDD:238020
		fn3	1317..1402	CDD:278470
		FN3	1415..1507	CDD:238020
		FN3	1513..1608	CDD:238020
		fn3	1617..1708	CDD:278470
		FN3	1722..1823	CDD:238020
		FN3	1828..1920	CDD:238020
		FN3	1927..2016	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810