DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bdl and ncam1a

DIOPT Version :9

Sequence 1:	NP_608822.1	Gene:	bdl / 33635	FlyBaseID:	FBgn0028482	Length:	719	Species:	Drosophila melanogaster
Sequence 2:	XP_009293555.1	Gene:	ncam1a / 30447	ZFINID:	ZDB-GENE-990415-31	Length:	1010	Species:	Danio rerio

Alignment Length:	779	Identity:	171/779 - (21%)
Similarity:	294/779 - (37%)	Gaps:	162/779 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 CTSAARDHRRQTNLEAKVGSHVVFNCYIDFP---------------FDAPIPYLVHWTKDNKKIF 79
            |.:.:.:...|..:..|:...:.|. |...|               ..:|.|.:: |.....:|
Zfish    94 CVAKSGEKESQGTIIVKIFQKLTFQ-YAPSPQEFNEGDDADIICDVISSPPPTII-WRYKKMRI- 155

  Fly    80 TWYEQETSTSELFNGRLHLVENHPEFGRASVNLTAIRESDQGWYHCQVSFPNRS----------- 133
               :.||..      ||.::.|:      .:.:..|:::|:|.|.|:.....|.
Zfish   156 ---QPETDV------RLKVLSNN------HLQIRGIKKTDEGDYTCEGRIMARGEIDLRVIKVIV 205

  Fly   134 ---PSVRNNGTAYHLAVQGGSLIRIPPVNQTIREGQTAFFHC-VMKHPENSQASWYKDGVLLQEV 194
               ||:|.               |...:|.|....|.....| ...:||.: ..|.:....|:..
Zfish   206 NVLPSIRT---------------RYTELNATADINQAVTLACHADGYPEPT-VKWARGNTELESD 254

  Fly   195 QDLVRRFYMGPDGS-LSIDPTMMSDLGEYECKVRNSDGELQTAKAFLNIQYKAKVIYAPPEVFLP 258
            :    ::.:..||| |:|......|.|:|:|..||..|| ::.:..||:..:.|:.:...:....
Zfish   255 E----KYSLNEDGSELTIKDVNKLDEGDYKCIARNKAGE-RSEEVTLNVFVQPKITFLENQTASE 314

  Fly   259 YGQPAVLDCHFRANPPLKNLRWEKDGLLFD-----SYNVPGVFYKMNG-----------SLFFAK 307
            ..:...|.|. ....|..|:.|.....:|.     |:..|.....::|           ||....
Zfish   315 LEEQITLTCE-ATGDPTPNIIWSFGRRVFTENEQASWTRPEKHKSLDGNVVVRSDARVSSLTLKY 378

  Fly   308 VDENHAGSYTCTPYNDLGTDGPSPVISVIVLRPPIFSVTPKAIYIQKLGEAAELPCEAIDRDGNN 372
            |....||.|.||..|.:|.|..|..:.| ...|.|..  |:|::..: |..|.:.|||:...|
Zfish   379 VQFTDAGQYLCTARNSIGQDIQSMYLEV-RYAPKIQG--PQAVFTWE-GNPANITCEALAHPG-- 437

  Fly   373 RPSIIWGRKDGQPLP-ADRFSLSGGN------LTITGLVEGDRGIYECSATNEAATITAEAELMI 430
             .|::|.| |||.|| |:..::...|      |.:|...:.|.|.|.|:|||...|.:.|. :::
Zfish   438 -ASVLWFR-DGQQLPSANTTNVKIYNTPTVSFLEVTPDSQNDFGSYNCTATNVIGTESKEF-ILV 499

  Fly   431 ENIAPRA-------PYNLTANSTETCITIRWQ----PGYLRPNLEYTVWYRLMEAPEWRTLRV-L 483
            :...|.|       ||:.||       .|.::    .|.: |.|:|...:|: ...:|..... |
Zfish   500 QADVPSAPSIERVEPYSSTA-------MIEFEEPASSGGV-PVLKYKAEWRI-AGQDWTDREYEL 555

  Fly   484 DKKVMEATVQHLQPGKEYEFMVLSQDKYGDGMFSKQFRFQTLPSPIRADDFDAQQLQHDLGQVTA 548
            :..:...|:..|:|...||..:.:.:..|:|..|....|:|  .|:|.....:.:....:...||
Zfish   556 EDGLNLITIVGLKPETTYEVKISAINGKGEGESSAPESFKT--QPVRLPFRMSPETPTSIPPTTA 618

  Fly   549 PAGGLGAPWNLTAISNQQG--WLLHWEHPVQGLEGLRLYAVRW-------WKEPEHFLIGHAETF 604
            ...|...|..|.|.....|  ..:|:.....|...::.|.||:       || ||   |...:..
Zfish   619 DIKGEPNPPKLEAKPQSTGNEMKVHFIKQDDGGSPIKHYLVRYRAKNRQDWK-PE---IRMPDAS 679

  Fly   605 DNYYQLRHLKEDTLFKVQVLA--------VGTETQQSVPSHELLIDVPSQRKVRALIIGSSVGVI 661
            | |..||.|..:|.::|.|:|        .||.:.:::|....:.:..|     .|..|:.||::
Zfish   680 D-YIVLRGLDWNTEYEVYVIAENQRGRSEPGTLSFRTLPEPTAIPETSS-----GLGTGAIVGIL 738

  Fly   662 FLLCALCAF-----LYVKRSCLRHLFAKDSSASEDEDTAESGDCDSDE----QDQRDRDSIKIR 716
            .::..|..|     .|....|...:....:...:...:|:|.|.:..:    :|:.....:::|
Zfish   739 IVVFILLLFGVDVTCYFLNKCGLLMCIAVNFCGKSGPSAKSKDIEEGKAAFTKDESKEPIVEVR 802

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bdl	NP_608822.1	IG_like	42..128	CDD:214653	18/100 (18%)
		Ig	43..131	CDD:299845	18/102 (18%)
		I-set	153..242	CDD:254352	23/90 (26%)
		Ig	157..242	CDD:299845	22/86 (26%)
		Ig_2	252..337	CDD:290606	22/100 (22%)
		IG_like	260..327	CDD:214653	19/82 (23%)
		I-set	341..428	CDD:254352	30/93 (32%)
		IGc2	356..419	CDD:197706	25/69 (36%)
		FN3	435..524	CDD:238020	23/100 (23%)
		FN3	554..636	CDD:238020	25/98 (26%)
ncam1a	XP_009293555.1	Ig	20..112	CDD:299845	3/17 (18%)
		I-set	21..111	CDD:254352	2/16 (13%)
		IG_like	121..200	CDD:214653	16/95 (17%)
		IGc2	128..189	CDD:197706	14/77 (18%)
		Ig	208..301	CDD:299845	27/113 (24%)
		IG_like	219..298	CDD:214653	22/84 (26%)
		Ig	300..406	CDD:299845	22/106 (21%)
		IG_like	308..406	CDD:214653	21/98 (21%)
		ig	413..498	CDD:278476	29/92 (32%)
		IG_like	415..498	CDD:214653	29/88 (33%)
		fn3	505..589	CDD:278470	20/92 (22%)
		FN3	624..715	CDD:238020	25/95 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900