DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bdl and Dscam4

DIOPT Version :9

Sequence 1:	NP_608822.1	Gene:	bdl / 33635	FlyBaseID:	FBgn0028482	Length:	719	Species:	Drosophila melanogaster
Sequence 2:	NP_001261571.1	Gene:	Dscam4 / 2769008	FlyBaseID:	FBgn0263219	Length:	1935	Species:	Drosophila melanogaster

Alignment Length:	674	Identity:	154/674 - (22%)
Similarity:	250/674 - (37%)	Gaps:	140/674 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 GSHVVFNCYI-DFPFDAPIPYLVHWTKDNKKIFTWYEQETSTSELFNGRLHLVENHPEFGRASVN 111
            ||.::..|.: .:|.|.     :||.:|.:.:.....|....    ||.| ::|.
  Fly   533 GSDLIVKCPVAGYPIDK-----IHWERDGQTLPINRRQRAYN----NGTL-IIEQ---------- 577

  Fly   112 LTAIRESDQGWYHCQVSFPNRSPSVRNNGTAYHLAVQGGSLIRIPP-------VNQTIREGQTAF 169
              ..|..|.|.|.|......:..|.||      :.:|    :.:||       :...:|||..|.
  Fly   578 --LQRLEDAGTYTCMAQNKQKQTSRRN------VEIQ----VLVPPKIMPIQAMTNMLREGMRAA 630

  Fly   170 FHC-VMKHPENSQASWYKDG-VLLQEVQDLVRRF--YMGPDGSLSIDPTMMSDLGEYECKVRNSD 230
            ..| :::........|.::| .|:....::.||.  |   ..||.|:.......|.|.|...|..
  Fly   631 ISCQILEGDLPVSFRWERNGKPLIGTGNEVFRRLDEY---SASLVIEHISSDHSGNYTCIASNVA 692

  Fly   231 G-ELQTAKAFLNIQYKAKVIYAPPEVFLPYGQPAVLDCHFRANPPLKNLRWEK-----DGLLFDS 289
            | |..|....:|:  ..|.|..|.:.....|...:|.|. .:..|...:.|:|     .|...|.
  Fly   693 GTERFTVPLTVNV--PPKWILEPKDSSAQAGADVLLHCQ-SSGYPTPTITWKKAIGPTPGEYKDF 754

  Fly   290 YNVPGVFYKMNGSLFFAKVDENHAGSYTCTPYNDLGTDGPSPVISVIVLRPPIFSVTPKAIYIQK 354
            ...|.|....||::||.|:.:...|.:.|...|::|: |.|.||.:.|..|..|....|.|.:.|
  Fly   755 LYEPTVQLFPNGTIFFKKISKESQGHFLCEAKNNIGS-GVSKVIFLKVNVPAHFQTKTKQISVAK 818

  Fly   355 LGEAAELPCEAIDRDGNNRPSIIWGRK----------DGQPLPADRFSLSG--GNLTITGLVEGD 407
             |:...:.|..   .|:|.....|..:          |.:....|:....|  ..|.|:.....|
  Fly   819 -GKQVHVQCNV---QGDNPIDFKWKIQATQQYLDESLDSRYTIRDQVLDDGMVSELGISHTYRQD 879

  Fly   408 RGIYECSATNEAATITAEAELMIENIAPRAPYNLTANSTET-CITIRWQPGYL--RPNLEYTVWY 469
            .|||.|.|:|.........:|:::.: |..|.||..||.:: .:.:.|...:.  .|..||.::|
  Fly   880 TGIYICQASNAFGQDEMSIQLIVQEV-PEQPKNLRINSQQSRSLQLTWSQPFAGNSPIEEYHIYY 943

  Fly   470 RLMEAPEWRT---LRVLDKKVMEATVQHLQPGKEYEFMVLSQDKYGDGMFSKQFRFQTL------ 525
            :.: :..|:.   |.:...:.: ..:|.|:|.|.|...:.:::|.|...||:..:..||
  Fly   944 KQI-SDIWQNAEHLTIAGAQTV-INIQQLRPAKAYHIRMSAENKLGASEFSEVVQVTTLEEVPSG 1006

  Fly   526 -PSPIRAD---------DFDAQQLQHDLGQVTAPAGGLGAPWNLTAISNQQGWLLHWE------H 574
             |..:||:         .:||.:..|               ||...:....|:.:...      :
  Fly  1007 PPLAVRAEPKSSTEIFVTWDAPERDH---------------WNGILLGYYVGYQMSLTPEDKEVN 1056

  Fly   575 PVQGLEGLRLYAVRWWKEPEHFLIGHAETFDNYYQLRHLKEDTLFKVQVLAVGTETQQSVPSHEL 639
            |.||. ..:...||     .||   ..||.     |.:|.:.|.:.|.|.|. |......||.|:
  Fly  1057 PTQGF-SFKTVEVR-----SHF---GGETV-----LANLNKFTQYHVIVQAY-TSQGSGPPSKEI 1106

  Fly   640 LI----DVPSQ--RKVRALIIGSS 657
            .:    ||||.  ...:..::||:
  Fly  1107 AVQTMEDVPSSPPESPQCDVLGST 1130

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bdl	NP_608822.1	IG_like	42..128	CDD:214653	18/80 (23%)
		Ig	43..131	CDD:299845	18/83 (22%)
		I-set	153..242	CDD:254352	23/100 (23%)
		Ig	157..242	CDD:299845	22/96 (23%)
		Ig_2	252..337	CDD:290606	24/89 (27%)
		IG_like	260..327	CDD:214653	19/71 (27%)
		I-set	341..428	CDD:254352	21/98 (21%)
		IGc2	356..419	CDD:197706	17/74 (23%)
		FN3	435..524	CDD:238020	22/94 (23%)
		FN3	554..636	CDD:238020	19/87 (22%)
Dscam4	NP_001261571.1	Ig	31..124	CDD:416386
		Ig strand A	32..35	CDD:409353
		Ig strand A'	41..45	CDD:409353
		Ig strand B	48..57	CDD:409353
		Ig strand D	75..78	CDD:409353
		Ig strand E	83..88	CDD:409353
		Ig strand F	101..109	CDD:409353
		Ig strand G	112..124	CDD:409353
		Ig	235..326	CDD:416386
		Ig strand A	235..238	CDD:409353
		Ig strand A'	244..248	CDD:409353
		Ig strand B	251..258	CDD:409353
		Ig strand C	266..271	CDD:409353
		Ig strand C'	276..279	CDD:409353
		Ig strand D	285..289	CDD:409353
		Ig strand E	292..298	CDD:409353
		Ig strand F	305..313	CDD:409353
		Ig strand G	316..326	CDD:409353
		IgC2_3_Dscam	329..417	CDD:409549
		Ig strand B	347..351	CDD:409549
		Ig strand C	360..364	CDD:409549
		Ig strand E	383..387	CDD:409549
		Ig strand F	397..402	CDD:409549
		Ig strand G	410..413	CDD:409549
		IgI_4_Dscam	422..516	CDD:409548
		Ig strand B	439..443	CDD:409548
		Ig strand C	452..456	CDD:409548
		Ig strand E	482..486	CDD:409548
		Ig strand F	496..501	CDD:409548
		Ig strand G	509..512	CDD:409548
		IgI_5_Dscam	520..607	CDD:409550	22/105 (21%)
		Ig strand B	536..540	CDD:409550	0/3 (0%)
		Ig strand C	549..553	CDD:409550	1/8 (13%)
		Ig strand E	571..575	CDD:409550	2/4 (50%)
		Ig strand F	586..591	CDD:409550	2/4 (50%)
		Ig strand G	600..603	CDD:409550	2/8 (25%)
		Ig	610..703	CDD:416386	23/95 (24%)
		Ig strand A	611..613	CDD:409353	1/1 (100%)
		Ig strand A'	620..624	CDD:409353	0/3 (0%)
		Ig strand B	627..636	CDD:409353	2/8 (25%)
		Ig strand C	641..648	CDD:409353	1/6 (17%)
		Ig strand C'	650..652	CDD:409353	1/1 (100%)
		Ig strand D	659..664	CDD:409353	1/4 (25%)
		Ig strand E	668..675	CDD:409353	3/6 (50%)
		Ig strand F	682..690	CDD:409353	3/7 (43%)
		Ig strand G	693..702	CDD:409353	3/8 (38%)
		IgI_7_Dscam	706..801	CDD:409546	26/96 (27%)
		Ig strand B	724..728	CDD:409546	1/3 (33%)
		Ig strand C	737..741	CDD:409546	0/3 (0%)
		Ig strand E	766..770	CDD:409546	1/3 (33%)
		Ig strand F	780..785	CDD:409546	1/4 (25%)
		Ig strand G	794..797	CDD:409546	1/2 (50%)
		Ig	818..904	CDD:416386	19/89 (21%)
		putative Ig strand B	820..827	CDD:409353	0/6 (0%)
		putative Ig strand C	835..841	CDD:409353	1/5 (20%)
		putative Ig strand C'	853..856	CDD:409353	0/2 (0%)
		putative Ig strand D	862..866	CDD:409353	0/3 (0%)
		putative Ig strand E	868..874	CDD:409353	2/5 (40%)
		putative Ig strand F	881..889	CDD:409353	5/7 (71%)
		putative Ig strand G	892..902	CDD:409353	1/9 (11%)
		FN3	906..999	CDD:238020	22/94 (23%)
		FN3	1006..1110	CDD:238020	28/133 (21%)
		fn3	1117..1203	CDD:394996	2/14 (14%)
		FN3	1215..1307	CDD:238020
Ig	<1334..1401	CDD:416386
Ig strand C	1345..1349	CDD:409353
Ig strand D	1363..1366	CDD:409353
Ig strand E	1367..1372	CDD:409353
Ig strand F	1380..1388	CDD:409353
Ig strand G	1394..1401	CDD:409353
FN3	1405..1494	CDD:238020
FN3	1499..1580	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10075
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910