DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bdl and Ncam1

DIOPT Version :9

Sequence 1:	NP_608822.1	Gene:	bdl / 33635	FlyBaseID:	FBgn0028482	Length:	719	Species:	Drosophila melanogaster
Sequence 2:	XP_038936733.1	Gene:	Ncam1 / 24586	RGDID:	67378	Length:	1136	Species:	Rattus norvegicus

Alignment Length:	708	Identity:	160/708 - (22%)
Similarity:	258/708 - (36%)	Gaps:	156/708 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 TNLEAKVGSHVVFNCYIDFPFDAPIPYLVHWTKDNKKIFTWYEQETSTSELFNGRLHLVENHPEF 105
            |..|.|.|...|..|.:    .:.:|..:.|....:.:.  .:::.....|.|..|
  Rat   125 TPQEFKEGEDAVIVCDV----VSSLPPTIIWKHKGRDVI--LKKDVRFIVLSNNYL--------- 174

  Fly   106 GRASVNLTAIRESDQGWYHCQVSFPNRSPSVRNNGTAYHLAVQGGSLIRIPP--------VNQTI 162
                 .:..|:::|:|.|.|:       ..:...|......:|  .::.:||        ||.|.
  Rat   175 -----QIRGIKKTDEGTYRCE-------GRILARGEINFKDIQ--VIVNVPPTVQARQSIVNATA 225

  Fly   163 REGQTAFFHCVMKHPENSQASWYKDGVLLQ-EVQDLVRRFYMGPDGSLSIDPTMMSDLGEYECKV 226
            ..||:....|..........||.|||..:: |.:|..:..:......|:|.....:|..||.|..
  Rat   226 NLGQSVTLVCDADGFPEPTMSWTKDGEPIENEEEDDEKHIFSDDSSELTIRNVDKNDEAEYVCIA 290

  Fly   227 RNSDGELQTAKAFLNIQYKAKVIYAPPEVFLPYGQPAVLDCHFRANPPLKNLRW----------- 280
            .|..|| |.|...|.:..|.|:.|...:..:...:...|.|. .:..|:.::.|
  Rat   291 ENKAGE-QDASIHLKVFAKPKITYVENQTAMELEEQVTLTCE-ASGDPIPSITWRTSTRNISSEE 353

  Fly   281 -------EKDGLLFDSYNVPGVFYKMNGSLFFAKVDENHAGSYTCTPYNDLGTDGPSPVISVIVL 338
                   ||...| |.:.|.....::: ||....:....||.|.||..|.:|.|..|..:.| ..
  Rat   354 KASWTRPEKQETL-DGHMVVRSHARVS-SLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV-QY 415

  Fly   339 RPPIFSVTPKAIYIQKLGEAAELPCEAIDRDGNNRPS--IIWGRKDGQPLPADRFS-------LS 394
            .|.:..  |.|:|..: |....:.||..     ..||  |.|.| |||.||:..:|       .|
  Rat   416 APKLQG--PVAVYTWE-GNQVNITCEVF-----AYPSATISWFR-DGQLLPSSNYSNIKIYNTPS 471

  Fly   395 GGNLTITGLVEGDRGIYECSATNEAATITAEAELMIENIAPRA-------PYNLTA----NSTET 448
            ...|.:|...|.|.|.|.|:|.|.....:.|. ::::...|.:       ||:.||    :..|.
  Rat   472 ASYLEVTPDSENDFGNYNCTAVNRIGQESLEF-ILVQADTPSSPSIDRVEPYSSTAQVQFDEPEA 535

  Fly   449 CITIRWQPGYLRPNLEYTVWYRLMEAPEWRTLRVLDKKV--ME--ATVQHLQPGKEYEFMVLSQD 509
            ...:        |.|:|...::.:....|.: :..|.|.  ||  .|:..|:|...|...:.:.:
  Rat   536 TGGV--------PILKYKAEWKSLGEEAWHS-KWYDAKEANMEGIVTIMGLKPETRYAVRLAALN 591

  Fly   510 KYGDGMFSKQFRFQTLP--SPIRADDFDAQQLQHDLGQVTAPAGGLGAPWNLTAISNQQGWLLHW 572
            ..|.|..|....|:|.|  ||....:..|.:|:..:|:     .|.....||  |....|.
  Rat   592 GKGLGEISAATEFKTQPVHSPPPQGEPSAPKLEGQMGE-----DGNSIKVNL--IKQDDGG---- 645

  Fly   573 EHPVQGLEGLRLYAVRW-------WKEPEHFLIGHAETFDNYYQLRHLKEDTLFKVQVLAVGTET 630
                   ..:|.|.|::       || ||..|    .:..::..|:.|..:..::|.|:|   |.
  Rat   646 -------SPIRHYLVKYRAKLASEWK-PEIRL----PSGSDHVMLKSLDWNAEYEVYVVA---EN 695

  Fly   631 QQ--SVPSHELL------IDVPSQRKVRA-LIIGSSVGVIFLLCAL--------CAFL 671
            ||  |..:|.:.      ..:|:.....| |..|:.||::.::..|        |.||
  Rat   696 QQGKSKAAHFVFRTSAQPTAIPANGSPTAGLSTGAIVGILIVIFVLLLVVMDITCYFL 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bdl	NP_608822.1	IG_like	42..128	CDD:214653	15/85 (18%)
		Ig	43..131	CDD:299845	15/87 (17%)
		I-set	153..242	CDD:254352	27/97 (28%)
		Ig	157..242	CDD:299845	26/93 (28%)
		Ig_2	252..337	CDD:290606	21/102 (21%)
		IG_like	260..327	CDD:214653	18/84 (21%)
		I-set	341..428	CDD:254352	28/95 (29%)
		IGc2	356..419	CDD:197706	24/71 (34%)
		FN3	435..524	CDD:238020	22/103 (21%)
		FN3	554..636	CDD:238020	21/90 (23%)
Ncam1	XP_038936733.1	IgI_1_NCAM-1	20..116	CDD:409451
		Ig strand B	37..41	CDD:409451
		Ig strand C	51..55	CDD:409451
		Ig strand E	79..83	CDD:409451
		Ig strand F	93..98	CDD:409451
		Ig strand G	107..110	CDD:409451
		IG_like	124..190	CDD:214653	15/84 (18%)
		Ig strand B	135..139	CDD:409353	1/3 (33%)
		Ig strand C	148..152	CDD:409353	0/3 (0%)
		Ig strand E	172..176	CDD:409353	1/17 (6%)
		Ig strand F	186..191	CDD:409353	2/11 (18%)
		IgI_3_NCAM-1	211..308	CDD:143207	27/97 (28%)
		Ig strand B	231..235	CDD:143207	0/3 (0%)
		Ig strand C	244..248	CDD:143207	1/3 (33%)
		Ig strand E	271..275	CDD:143207	1/3 (33%)
		Ig strand F	285..290	CDD:143207	3/4 (75%)
		Ig strand G	298..301	CDD:143207	1/2 (50%)
		IgI_NCAM-1	307..413	CDD:143277	23/108 (21%)
		Ig strand B	326..330	CDD:143277	1/3 (33%)
		Ig strand C	339..343	CDD:143277	0/3 (0%)
		Ig strand E	379..383	CDD:143277	2/4 (50%)
		Ig strand F	393..398	CDD:143277	2/4 (50%)
		Ig strand G	406..409	CDD:143277	0/2 (0%)
		Ig_3	422..494	CDD:404760	26/78 (33%)
		Ig strand B	433..437	CDD:409353	0/3 (0%)
		Ig strand C	446..450	CDD:409353	1/3 (33%)
		Ig strand E	473..477	CDD:409353	1/3 (33%)
		Ig strand F	487..492	CDD:409353	2/4 (50%)
		FN3	509..606	CDD:238020	22/105 (21%)
		fn3	619..701	CDD:394996	24/107 (22%)
		Herpes_BLLF1	<842..1133	CDD:282904
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900