DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bdl and SDK1

DIOPT Version :9

Sequence 1:	NP_608822.1	Gene:	bdl / 33635	FlyBaseID:	FBgn0028482	Length:	719	Species:	Drosophila melanogaster
Sequence 2:	NP_689957.3	Gene:	SDK1 / 221935	HGNCID:	19307	Length:	2213	Species:	Homo sapiens

Alignment Length:	670	Identity:	148/670 - (22%)
Similarity:	239/670 - (35%)	Gaps:	164/670 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 QTNLEAKVGSHVVFNCYIDFPFDAPIPYLVHWTKDNKKIFTWYEQETSTSELFNGRLHLVENHPE 104
            ::.:.|:|...|...|.   ....|:|.|           .||:...|.|.|.|.|..::.:
Human   393 ESRISAEVEETVDIGCQ---AMGVPLPTL-----------QWYKDAISISRLQNPRYKVLAS--- 440

  Fly   105 FGRASVNLTAIRESDQGWYHCQVSFPNRSPSVRNNG----TAYHLAVQG-GSLIRIPPVNQTIRE 164
               ..:.:..:|..|.|.:.|..|         |.|    |..:|.|.. ..:....||:.|:.:
Human   441 ---GGLRIQKLRPEDSGIFQCFAS---------NEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTD 493

  Fly   165 GQTAFFHCVMKHPENSQASWYKDGVLLQEVQDLVRRFYMGPDGSLSIDPTMMSDLGEYECKVRNS 229
            |.||...|.:........:|.::..:|......:.||.:...|.|.|.|..:.|.|.|.|...|:
Human   494 GMTAILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTCYAANT 558

  Fly   230 DGELQTAKAFLNIQYKAKVIYAPPEVFLPYGQPAVLDCHFRANPPLKNLR--WEKDGLLFDSYNV 292
            :|.| .|.|.|.:..:..:::.|.:..:..|..|.|.|. ..:.|..:||  |:||.:.....:.
Human   559 EGSL-NASATLTVWNRTSIVHPPEDHVVIKGTTATLHCG-ATHDPRVSLRYVWKKDNVALTPSST 621

  Fly   293 PGVFYKMNGSLFFAKVDENHAGSYTCTPYNDLGTDGPSPVISVIVL--RPPIFSVTPKA------ 349
            ..:..:.:|||..::......|.|:|...::.|.|.....:.||.|  .|....|:|.:
Human   622 SRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPHSPQNLLVSPNSSHSHAV 686

  Fly   350 ---------------IYIQKLGEAAELPCEAIDRDGNNRPSIIWGRKDGQPLPADRFSLSG---- 395
                           .||.:|.|             ||.|   |           :..||.
Human   687 VLSWVRPFDGNSPILYYIVELSE-------------NNSP---W-----------KVHLSNVGPE 724

  Fly   396 -GNLTITGLVEGDRGIYECSATNEAATITAEAE---LMIENIAPRA-PYNLTANS-TETCITIRW 454
             ..:|::||.......:...|.||.......||   ||:....|.| |.|:.|:. |...|.::|
Human   725 MTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQW 789

  Fly   455 QP-------GYLRPNLEYTVWYRLMEAP-EWRTLRVLDKKVMEATVQHLQPGKEYEFMVLSQDKY 511
            ||       |.||   .|.:.|||...| |::...:...:|....|..|....:||..|.:.:..
Human   790 QPPPETEHNGVLR---GYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYNGA 851

  Fly   512 GDGMFSKQFRFQTL-------PSPIRADDFDAQQLQHDLGQVTAPAGGLGAPWN------LTAIS 563
            |.|:||:.....||       |..::.:..::..:|.              .||      :..|:
Human   852 GLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQF--------------LWNPPPQQFINGIN 902

  Fly   564 NQQGW-LLHWEHPVQGLEGLRLYAVRWWKEPEHFLIGHAETFDNYYQLRHLKEDTLFKVQVLAVG 627
              ||: ||.|  |....|.:.:..:    .|:...:.|.       .:.:||:.|.:...||...
Human   903 --QGYKLLAW--PADAPEAVTVVTI----APDFHGVHHG-------HITNLKKFTAYFTSVLCFT 952

  Fly   628 TE------------TQQSVP 635
            |.            ||:..|
Human   953 TPGDGPPSTPQLVWTQEDKP 972

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bdl	NP_608822.1	IG_like	42..128	CDD:214653	18/85 (21%)
		Ig	43..131	CDD:299845	19/87 (22%)
		I-set	153..242	CDD:254352	25/88 (28%)
		Ig	157..242	CDD:299845	25/84 (30%)
		Ig_2	252..337	CDD:290606	20/86 (23%)
		IG_like	260..327	CDD:214653	17/68 (25%)
		I-set	341..428	CDD:254352	20/115 (17%)
		IGc2	356..419	CDD:197706	12/67 (18%)
		FN3	435..524	CDD:238020	29/98 (30%)
		FN3	554..636	CDD:238020	21/101 (21%)
SDK1	NP_689957.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..73
		I-set	104..188	CDD:254352
		Ig	122..176	CDD:143165
		Ig	219..265	CDD:299845
		IGc2	312..364	CDD:197706
		I-set	386..475	CDD:254352	23/110 (21%)
		Ig	404..472	CDD:143165	20/96 (21%)
		I-set	480..570	CDD:254352	25/90 (28%)
		Ig	494..570	CDD:299845	22/76 (29%)
		I-set	575..664	CDD:254352	19/89 (21%)
		Ig	580..664	CDD:299845	19/84 (23%)
		FN3	668..759	CDD:238020	21/117 (18%)
		fn3	771..857	CDD:278470	25/88 (28%)
		FN3	872..967	CDD:238020	20/123 (16%)
		FN3	972..1054	CDD:238020	1/1 (100%)
		FN3	1070..1166	CDD:238020
		FN3	1176..1271	CDD:238020
		fn3	1279..1365	CDD:278470
		FN3	1378..1471	CDD:238020
		FN3	1477..1572	CDD:238020
		FN3	1580..1694	CDD:238020
		FN3	1704..1797	CDD:238020
		FN3	1802..1883	CDD:238020
		FN3	1903..1996	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2075..2098
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:Q6V4S5	2207..2213
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810