DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bdl and FCGR2A

DIOPT Version :9

Sequence 1:	NP_608822.1	Gene:	bdl / 33635	FlyBaseID:	FBgn0028482	Length:	719	Species:	Drosophila melanogaster
Sequence 2:	XP_011507589.1	Gene:	FCGR2A / 2212	HGNCID:	3616	Length:	369	Species:	Homo sapiens

Alignment Length:	352	Identity:	62/352 - (17%)
Similarity:	115/352 - (32%)	Gaps:	92/352 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 PPVNQTIREGQTAFFHCVMKHPENSQASWYKDGVLLQEVQDLVRRFYMGPDGSLSIDPTMMSDLG 220
            ||....::|..........:.||:....|:.:|.|:........||           ....:|.|
Human    47 PPWINVLQEDSVTLTCQGARSPESDSIQWFHNGNLIPTHTQPSYRF-----------KANNNDSG 100

  Fly   221 EYECKVRNSDGELQTAKAFLNIQYKAKV-----IYAPPEVFLPYGQPAVLDCHFRANPPL----- 275
            ||.|         ||.:..|:......|     :...|.:....|:..:|.||...:.||
Human   101 EYTC---------QTGQTSLSDPVHLTVLSEWLVLQTPHLEFQEGETIMLRCHSWKDKPLVKVTF 156

  Fly   276 -KNLRWEKDGLLFDSYNVPGVFYKMNGSLFFAKVDENHAGSYTCT-----------PYN------ 322
             :|.:.:|...|..::::|             :.:.:|:|.|.||           |..
Human   157 FQNGKSQKFSHLDPTFSIP-------------QANHSHSGDYHCTGNIGYTLFSSKPVTITVQVP 208

  Fly   323 DLGTDGPSPVISVIVLRPPIFSVTPKA---IYIQKLGEAAEL--PCEAIDRDGNNRPSIIWGRKD 382
            .:|:..|..:|..:|:...:.::....   ||.:|...:|..  |.:|...:...|..|...::.
Human   209 SMGSSSPMGIIVAVVIATAVAAIVAAVVALIYCRKKRISANSTDPVKAAQFEPPGRQMIAIRKRQ 273

  Fly   383 GQPLPADRFSLSGGNLTIT--GLVEGDRGIYECSATNEAATITAEAELMIENIAPRAPYNLTANS 445
            .:....|..:..||.:|:.  ...:.|:.||.....|:..                        :
Human   274 LEETNNDYETADGGYMTLNPRAPTDDDKNIYLTLPPNDHV------------------------N 314

  Fly   446 TETCITIRWQPGYLRPNLEYTVWYRLM 472
            |....|:.|.....:..|:....:||:
Human   315 TNKAFTLFWNTSCQKGKLQVNCQWRLL 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bdl	NP_608822.1	IG_like	42..128	CDD:214653
		Ig	43..131	CDD:299845
		I-set	153..242	CDD:254352	18/85 (21%)
		Ig	157..242	CDD:299845	17/84 (20%)
		Ig_2	252..337	CDD:290606	20/107 (19%)
		IG_like	260..327	CDD:214653	17/89 (19%)
		I-set	341..428	CDD:254352	16/93 (17%)
		IGc2	356..419	CDD:197706	13/66 (20%)
		FN3	435..524	CDD:238020	6/38 (16%)
		FN3	554..636	CDD:238020
FCGR2A	XP_011507589.1	Ig1_FcgammaR_like	41..119	CDD:143229	18/91 (20%)
		IG_like	47..119	CDD:214653	18/91 (20%)
		Ig2_FcgammaR_like	123..205	CDD:143230	17/94 (18%)
		IG_like	129..205	CDD:214653	17/88 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910