DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bdl and HEPACAM

DIOPT Version :9

Sequence 1:	NP_608822.1	Gene:	bdl / 33635	FlyBaseID:	FBgn0028482	Length:	719	Species:	Drosophila melanogaster
Sequence 2:	XP_016872850.1	Gene:	HEPACAM / 220296	HGNCID:	26361	Length:	468	Species:	Homo sapiens

Alignment Length:	499	Identity:	102/499 - (20%)
Similarity:	161/499 - (32%)	Gaps:	136/499 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 AKRSRTFRQSGSALLALLAIILLMNISCTSAARDHRRQTNLEAKVGSHVVFNC-YIDFPFDAPIP 66
            ::.||..|.:....|.|:....|..::.||..|      .:...||...:.:. |.....|.|:
Human     9 SRASRALRLAPFVYLLLIQTDPLEGVNITSPVR------LIHGTVGKSALLSVQYSSTSSDRPV- 66

  Fly    67 YLVHWTKDNKKIFTWYEQETSTSEL------FNGRLHLVENHPEFGRASVNLTAIRESDQGWYHC 125
              |.|.....|..| ..|...|..:      :..|:.|.||      .|:.|:.::.:|:|.|..
Human    67 --VKWQLKRDKPVT-VVQSIGTEVIGTLRPDYRDRIRLFEN------GSLLLSDLQLADEGTYEV 122

  Fly   126 QVSFPNRSPSVRNNGTAYHLAVQGGSLIRIP---PVNQ--------TIREGQTAF-FHCVMKHPE 178
            ::|..:.:             ..|...|.:.   |:::        |:.|...|| .:|..::..
Human   123 EISITDDT-------------FTGEKTINLTVDVPISRPQVLVASTTVLELSEAFTLNCSHENGT 174

  Fly   179 NSQASWYKDG-VLLQEVQDLVRRFYMGPDGS-LSIDPTMMSDLGEYECKVRN--SDGELQTAKAF 239
            ....:|.||| .||.:     .|..:.||.. |:|...:|.|...|.|.|.|  |.|.....|..
Human   175 KPSYTWLKDGKPLLND-----SRMLLSPDQKVLTITRVLMEDDDLYSCMVENPISQGRSLPVKIT 234

  Fly   240 LNIQYKAKVIYAPPEVFLPYGQPAVLDCHFRANPPLKNLRWEKDGLLFDSYNVPGVFYKMNGSLF 304
            :..:....:|.:...:||......|..|...:....|.|.                  |.|...:
Human   235 VYRRSSLYIILSTGGIFLLVTLVTVCACWKPSKRKQKKLE------------------KQNSLEY 281

  Fly   305 FAKVDENHAGSYTCTPYNDL-GTDGPSPVI------------------SVIVLRPPIFSVTPKAI 350
            ..:.|:.      ..|..:| .|..|.|..                  |...|.||    |.:.:
Human   282 MDQNDDR------LKPEGELPATQSPIPSTIRSVGCWEKAELGDKENSSAGTLPPP----TARRL 336

  Fly   351 Y-IQKLGEAAELPCEAIDRDG---NNRPSIIWGRKD-------GQPLPADRFSLSGG--NLTITG 402
            . .::.|:|..||     |.|   ...|..::..||       ..|.|..|.:...|  ..:::.
Human   337 QRRERFGQADTLP-----RSGEQERKNPMALYILKDKDSPETEENPAPEPRSATEPGPPGYSVSP 396

  Fly   403 LVEG-DRGI-------YECSATNEAATITAEAELMIENIAPRAP 438
            .|.| ..|:       |..|.....||....:.      .||||
Human   397 AVPGRSPGLPIRSARRYPRSPARSPATGRTHSS------PPRAP 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bdl	NP_608822.1	IG_like	42..128	CDD:214653	20/92 (22%)
		Ig	43..131	CDD:299845	21/94 (22%)
		I-set	153..242	CDD:254352	27/104 (26%)
		Ig	157..242	CDD:299845	26/97 (27%)
		Ig_2	252..337	CDD:290606	15/103 (15%)
		IG_like	260..327	CDD:214653	9/67 (13%)
		I-set	341..428	CDD:254352	22/107 (21%)
		IGc2	356..419	CDD:197706	18/82 (22%)
		FN3	435..524	CDD:238020	4/4 (100%)
		FN3	554..636	CDD:238020
HEPACAM	XP_016872850.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000