DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bdl and DSCAM

DIOPT Version :9

Sequence 1:	NP_608822.1	Gene:	bdl / 33635	FlyBaseID:	FBgn0028482	Length:	719	Species:	Drosophila melanogaster
Sequence 2:	NP_001380.2	Gene:	DSCAM / 1826	HGNCID:	3039	Length:	2012	Species:	Homo sapiens

Alignment Length:	724	Identity:	168/724 - (23%)
Similarity:	266/724 - (36%)	Gaps:	210/724 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 PIPYLVHWTKDNKKIFTWYEQETSTSELFNGRLHLVENHPEFGRASVNLTAIRESDQGWYHCQVS 128
            |:| .:.||.|:..|.......  .|::.....::|        :.:|:::.:..|.|.|.|..
Human   434 PLP-TITWTLDDDPILKGGSHR--ISQMITSEGNVV--------SYLNISSSQVRDGGVYRCTA- 486

  Fly   129 FPNRSPSVRNNGTAY--HLAVQGGSLIRIPPVNQTIREGQTAFFHC-VMKHPENSQASWYKDGVL 190
              |.|..|    ..|  .:.|:|.:.|| |..|.|...|:..:.|| |:.:|..| ..|||:..|
Human   487 --NNSAGV----VLYQARINVRGPASIR-PMKNITAIAGRDTYIHCRVIGYPYYS-IKWYKNSNL 543

  Fly   191 LQEVQDLVRRFYMGPDGSLSI-DPTMMSDLGEYECKVRNSDGELQTAKAFLNIQYKAKVIYAPPE 254
            |....   |:.....:|:|.: |.....|.|||.|.|. ...:|.|::   ::....||    |.
Human   544 LPFNH---RQVAFENNGTLKLSDVQKEVDEGEYTCNVL-VQPQLSTSQ---SVHVTVKV----PP 597

  Fly   255 VFLPY-------GQPAVLDCHFRANPPLKNLRWEKDGLLFDSYNVPGVF------YKMNGSLFFA 306
            ...|:       ||...:.|...:......:.|:|||     ..:||..      .....||..:
Human   598 FIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDG-----RPIPGSLGVTIDNIDFTSSLRIS 657

  Fly   307 KVDENHAGSYTCTPYND-LGTDGPSPVISVIVLRPPIFSVTPK---AIYIQKLGEAAELPCEAID 367
            .:...|.|:|||...|: ...:..|   .:||..||.|.|.|:   .||    |:|..|.|.|
Human   658 NLSLMHNGNYTCIARNEAAAVEHQS---QLIVRVPPKFVVQPRDQDGIY----GKAVILNCSA-- 713

  Fly   368 RDGNNRPSIIWGRKDGQPLPADRFS----------LSGGNLTITGLVEGDRGIYECSATNE-AAT 421
             :|...|:|:|....|..:|  :|.          ||.|:|.|..:||.|.|.|.|..:|: .|.
Human   714 -EGYPVPTIVWKFSKGAGVP--QFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGAD 775

  Fly   422 ITAEAELMIENIAPRAPYNLTANSTE------TC-------ITIRW--QPGYLRPNL-EYTVWYR 470
            ::....|.::..|....|..|..:|:      :|       |.:||  :...:.|.: .|.|..:
Human   776 VSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTK 840

  Fly   471 LMEAPEWRTLRVL--------------------DKKVMEATVQHLQPGKEYEFMVLSQDKYGDGM 515
            .:......||::|                    |:.:::.|||......|.|.
Human   841 EVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEI------------ 893

  Fly   516 FSKQFRFQTLP----------SPI---------RADDFDAQQLQHD----LGQVTA----PAG-- 551
              |..:.:|:.          |||         ::|.:|:.|...|    |...|.    |:.
Human   894 --KDVKARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTY 956

  Fly   552 ----------GLGAPWN-LTAISNQQGWLLHWEHPVQ--GLEGLRLYAVR-WWKEPEHFL----- 597
                      |...|.| ||..:::..    .:.|.|  .||.:...::| .||.|:..|
Human   957 SIRMYAKNRIGKSEPSNELTITADEAA----PDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGII 1017

  Fly   598 ----IGHAE--TFDNY---------------YQLRHLKEDTLFKVQVLA-----VGTETQQSVPS 636
                ||:.|  |..|:               |.|.:|.:.|.:.:.|.|     .|..:|:.:.:
Human  1018 RGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITT 1082

  Fly   637 HELLIDVPS 645
              .|.||||
Human  1083 --TLEDVPS 1089

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bdl	NP_608822.1	IG_like	42..128	CDD:214653	13/63 (21%)
		Ig	43..131	CDD:299845	13/66 (20%)
		I-set	153..242	CDD:254352	28/90 (31%)
		Ig	157..242	CDD:299845	25/86 (29%)
		Ig_2	252..337	CDD:290606	20/98 (20%)
		IG_like	260..327	CDD:214653	17/73 (23%)
		I-set	341..428	CDD:254352	31/100 (31%)
		IGc2	356..419	CDD:197706	24/73 (33%)
		FN3	435..524	CDD:238020	20/124 (16%)
		FN3	554..636	CDD:238020	26/116 (22%)
DSCAM	NP_001380.2	Ig	45..113	CDD:319273
		I-set	235..310	CDD:254352
		I-set	315..385	CDD:333254
		Ig_3	407..488	CDD:316449	13/67 (19%)
		IGc2	518..575	CDD:197706	19/60 (32%)
		I-set	596..686	CDD:333254	20/97 (21%)
		Ig_DSCAM	707..784	CDD:143211	24/81 (30%)
		Ig	802..889	CDD:325142	14/86 (16%)
		FN3	885..978	CDD:238020	19/106 (18%)
		FN3	986..1083	CDD:238020	22/98 (22%)
		FN3	1091..1184	CDD:238020
		FN3	1189..1278	CDD:238020
		Ig	1303..1369	CDD:319273
		FN3	1380..1470	CDD:238020
		FN3	1486..1555	CDD:238020
		Required for netrin-mediated axon repulsion of neuronal growth cones. /evidence=ECO:0000250\|UniProtKB:Q9ERC8	1617..2012
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1718..1810
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1855..1883
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1971..2012
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10075
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910