DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bdl and rig-3

DIOPT Version :9

Sequence 1:	NP_608822.1	Gene:	bdl / 33635	FlyBaseID:	FBgn0028482	Length:	719	Species:	Drosophila melanogaster
Sequence 2:	NP_509155.1	Gene:	rig-3 / 180958	WormBaseID:	WBGene00004370	Length:	487	Species:	Caenorhabditis elegans

Alignment Length:	495	Identity:	99/495 - (20%)
Similarity:	169/495 - (34%)	Gaps:	153/495 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   260 GQPAVLDCHFRANPPL--KNLRWEK-DGLLFDSYNVPGVFYKM---------NGSLFFAKVDENH 312
            |:..::.|.|.::..:  .:|.|:: :|...|..:.|.:|..:         ..||.|:.|....
Worm    54 GKKLMVSCVFESDEQIHKSDLLWKQANGNNIDGESNPSLFSVILNEKGSKHRKTSLHFSSVHTRD 118

  Fly   313 AGSYTCTPYNDLGTDGPSPVISVIVLRPPIFSVTPKAIYIQKLGEAAELPCEAIDRDGNNRPSII 377
            .|.||||. ...|.:.....|.::|| |.|.......:....|||...:.| .:.......|.|.
Worm   119 TGLYTCTG-RTAGGENFEKTIKLVVL-PAIEWNDKDTVKGALLGEPITIDC-GVKGPSGKEPMIQ 180

  Fly   378 WGRKDGQPLPADRFSLSGGNLTITGLVEGDRGIYECSATNEAATITAEAELMIENIAPRAPYNLT 442
            ....:|:||..:.::::|...||..|.:                  ..|||
Worm   181 MTNGNGEPLDEEIWTIAGNEATIDSLKK------------------EHAEL-------------- 213

  Fly   443 ANSTETCITIRWQ--------PGYLRPNLEYTVWYRLMEAPEWRT-----LRVLDKKVMEA---- 490
               |.:||||...        |...|.::...| |.|   ||:.|     ..|:|..|.:|
Worm   214 ---TVSCITIEMHQETSKEEFPVVDRKDVNIEV-YTL---PEFETEESVQYTVIDNHVRDAIIYC 271

  Fly   491 TVQH-LQPGKEYEFMVLSQDKYGDGMFSKQFRFQTLPSPIRADDFDAQQL------QHDLGQVTA 548
            .|.| ..|.:.|.|.      :||.......:|...   :.........|      ::|||....
Worm   272 NVTHSFPPVRHYTFY------HGDEEIKMSDKFNIF---VNVGVSQGAHLKIHNVNENDLGTYKC 327

  Fly   549 PAGGLGA----------------PWNLTAISNQQGWLLHWEHPVQGLE---GLRLYAVRWWKEPE 594
            .|..:.|                | .:|.|.:::..:: |:  |:.::   .|.:.||    |..
Worm   328 EANNIKAKSYHTIHLREANAPAEP-KVTLIEDKRHSII-WK--VESIDRDPDLPMTAV----EIR 384

  Fly   595 HFLIGHAET--------FDNY------YQLRHLKEDTLFKVQVLAVGTE---------------- 629
            |...|.||.        .|.|      :..|::|:|.::::..|..|.|
Worm   385 HLRAGTAEASGVSDEDISDAYWKSHSIFMQRNIKDDGIYEINGLRHGHEYVWRFRQINEAGFGDS 449

  Fly   630 ---TQQSVPSHEL-LIDVPSQRKVRALIIGSSVGVIFLLC 665
               ..:::..|:| ::|..|..|     ...::..:|.:|
Worm   450 VVLRAKTLDDHDLEMMDSASDSK-----FPLALATLFFVC 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bdl	NP_608822.1	IG_like	42..128	CDD:214653
		Ig	43..131	CDD:299845
		I-set	153..242	CDD:254352
		Ig	157..242	CDD:299845
		Ig_2	252..337	CDD:290606	20/88 (23%)
		IG_like	260..327	CDD:214653	19/78 (24%)
		I-set	341..428	CDD:254352	15/86 (17%)
		IGc2	356..419	CDD:197706	12/62 (19%)
		FN3	435..524	CDD:238020	25/106 (24%)
		FN3	554..636	CDD:238020	22/133 (17%)
rig-3	NP_509155.1	IG_like	48..142	CDD:214653	20/88 (23%)
rig-3	NP_509155.1	Ig	267..341	CDD:319273	15/82 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10075
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000