DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bdl and igcm-2

DIOPT Version :9

Sequence 1:	NP_608822.1	Gene:	bdl / 33635	FlyBaseID:	FBgn0028482	Length:	719	Species:	Drosophila melanogaster
Sequence 2:	NP_001362087.1	Gene:	igcm-2 / 180913	WormBaseID:	WBGene00020130	Length:	802	Species:	Caenorhabditis elegans

Alignment Length:	679	Identity:	154/679 - (22%)
Similarity:	256/679 - (37%)	Gaps:	196/679 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 LEAKVGSHVVFNCYIDFPFDAPIPYLVHWTKDNKKIFTWYEQETSTSELFNGRLHLVENHPEFGR 107
            :..|||:.::|.|..:   .||.|.:. |:::        ||..|||.:
Worm   135 IHKKVGADLIFECKAE---GAPSPEIT-WSRN--------EQIISTSPV---------------- 171

  Fly   108 ASVNLTAIRESDQGWYHCQVSFPNRSPSVRNNGT-AYHLAVQGGSLIRIPPVNQTIREGQTAFFH 171
              :.|:.:.|.|:|.|.|      .:.::..|.| :..:.....:::.:.|:|:|:.||...|:|
Worm   172 --LTLSNLEEGDKGLYTC------LAVNIEGNSTSSIDVRFTKATILDLIPLNKTVIEGSNVFWH 228

  Fly   172 CVMKHPENSQA-----SWYKDGVLLQEVQDLVRRFYMG-----PDGSLSIDPTMMSDLGEYECKV 226
            |   | .|:||     ||..:       :..::...:|     ..|.||:.....||.|.|.|:.
Worm   229 C---H-ANAQATAISYSWLFE-------KKPIKTTSLGLRSNIRSGDLSLQDVRKSDSGWYTCEA 282

  Fly   227 RNSDGELQTAKAFLNIQYKAKVIYAPPEVFLPY--------GQPAVLDCHFRANPPLKNLRWEKD 283
            :||.||..::.|:|::.|       |||....:        |:...:.|...|||...:..|.|:
Worm   283 KNSAGETTSSTAYLHVFY-------PPEPLSSHQPVQTVASGRNTTVSCDVIANPTPTSYTWSKN 340

  Fly   284 G---------LLFDSYNVPGVFYKMNGSLFFAKVDENHAGSYTCTPYNDLGTDGPSPVISVIVLR 339
            |         .:..||..||     :|.::..:.| |.||.            |......:||..
Worm   341 GHYLPTQASSHIIISYAKPG-----DGGIYGCQAD-NIAGK------------GSIVETHLIVAE 387

  Fly   340 PPIFSVTPKAIYIQKLGEAAELPCEAIDRDGNNRPSIIWGRKDGQPLPADRFSLSGGNLTITGLV 404
            ||:|:|.|.:....:||:...:||:..   |:..|.:.|.|        |:..::...||...:.
Worm   388 PPVFTVAPPSEIKVRLGDQVSIPCQGF---GDPMPIVYWIR--------DKKRINQSTLTFKKVE 441

  Fly   405 EGDRGIYECSATNEAATITAEAELMIENIAPRAPYNLTANSTETCIT-----IRWQPGY------ 458
            ..|.|.|||...|...||:....|::|...|:    :.::...||:.     |.|.|||
Worm   442 HLDHGAYECVVANSVETISTRVMLLVEITKPQ----MASSIKFTCLNSSSMRISWTPGYNGGFDQ 502

  Fly   459 ---LRPNLEYTVWYRLMEAPEWRTLRVLDKKVMEATVQHLQPGKEYEFMVLSQDKYGDGMFSKQF 520
               :....:.|:        :|.:::.   .:.|..:.||:|...|...:.|.:..|
Worm   503 TFAVHAQNDVTL--------QWTSIKT---SLNETILDHLEPFVSYRVSIESVNAKG-------- 548

  Fly   521 RFQTLPSPIRADDFDAQQLQHDLGQVTAPAGGLGAPWNLTAIS-NQQGWLLHWEHPVQGLEGLRL 584
                          ......::....|:    |.||..|.... |:..|        ...||...
Worm   549 --------------STNSTTYNRRSCTS----LHAPDKLYFCGYNELCW--------TAAEGASS 587

  Fly   585 YAVRWWKEPEHFLIGHAETFDNYYQL-RHLKE--DTLFKVQVLAVGTETQQSVPSHELLIDVPSQ 646
            |.:....||.......||..:.||:| :.:.|  .|:|:|:      .|:.|.|..|     ||
Worm   588 YRIESRTEPSKNFQPLAEVLETYYRLGKDVDETKQTIFRVR------STRPSYPPSE-----PS- 640

  Fly   647 RKVRALIIGSSVGV---IFLLCALCAFLY 672
               .||..|.:..|   ||:|.|:...|:
Worm   641 ---NALRYGIADNVDLPIFMLAAVFGLLF 666

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bdl	NP_608822.1	IG_like	42..128	CDD:214653	20/84 (24%)
		Ig	43..131	CDD:299845	20/87 (23%)
		I-set	153..242	CDD:254352	29/98 (30%)
		Ig	157..242	CDD:299845	29/94 (31%)
		Ig_2	252..337	CDD:290606	21/101 (21%)
		IG_like	260..327	CDD:214653	17/75 (23%)
		I-set	341..428	CDD:254352	23/86 (27%)
		IGc2	356..419	CDD:197706	16/62 (26%)
		FN3	435..524	CDD:238020	17/102 (17%)
		FN3	554..636	CDD:238020	21/85 (25%)
igcm-2	NP_001362087.1	IG_like	23..101	CDD:214653
		Ig	124..200	CDD:386229	22/100 (22%)
		IG_like	214..298	CDD:214653	29/94 (31%)
		Ig_3	309..371	CDD:372822	14/67 (21%)
		Ig	389..467	CDD:386229	24/88 (27%)
		FN3	476..548	CDD:238020	15/82 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	113	1.000	Inparanoid score	I3426
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14609
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.820