DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bdl and ncam-1

DIOPT Version :9

Sequence 1:	NP_608822.1	Gene:	bdl / 33635	FlyBaseID:	FBgn0028482	Length:	719	Species:	Drosophila melanogaster
Sequence 2:	NP_741709.1	Gene:	ncam-1 / 180418	WormBaseID:	WBGene00017184	Length:	955	Species:	Caenorhabditis elegans

Alignment Length:	305	Identity:	80/305 - (26%)
Similarity:	120/305 - (39%)	Gaps:	60/305 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 LAVQGGSLIRIPPVNQTI---REGQTAFFHCVMKH----PENSQASWYKDGVLLQEVQD--LVRR 200
            |.:..|..:.:.|..:.:   |.|......|.:|.    ..:::..||:||.|:.....  .:.|
Worm    41 LLILSGWTLSLSPTEERLQNRRSGDNFLVVCKVKDFDGAASDAKIEWYRDGKLIPRFGSTMTIER 105

  Fly   201 FYMGPDGSLSIDPTMMSDLGEYECKVRNSDGELQTAKA---------FLNIQYKAKVIYAPPEVF 256
            .|   ...|.|:...:||.|:|.||. ...||.|...|         |||:|....    |.|
Worm   106 TY---SNQLMINRPKISDGGKYTCKT-EIQGEQQEVSAEISFVDPPKFLNVQESQH----PEE-- 160

  Fly   257 LPYGQPAVLDCHFRANPPLKNLRWEKDGLLFDSYNVPGVFYKMNGSL-----FFAKVDENHAGSY 316
               |..|.:.|.......|: :.|:.:|:..|..:..|..:..|..:     |.||.|:   |.|
Worm   161 ---GTRAEIVCEVEGTDQLE-VFWQFNGVTLDETSQRGYEFSENNQILYIPHFTAKKDD---GIY 218

  Fly   317 TC--TPYNDLGTDGPSPVISVIV---LRPPI--FSVTPKAIYIQKLGEAAELPCEAIDRDGNNRP 374
            .|  ..|:...|      :||.|   .||.|  |.|......|:  |...||.|.|:   |..:|
Worm   219 NCNAAQYSSFET------LSVNVTGYARPTITVFDVPNGNRGIE--GHTIELKCGAV---GKPKP 272

  Fly   375 SIIWGRKDGQ-PLP-ADRFSLSGGNLTITGLVEGDRGIYECSATN 417
            :..|..:|.: |:. :|:.::..|.|.|..|...|.|.|:|.|.|
Worm   273 TYKWFFEDDEVPIARSDKHNVEEGLLIIESLNSEDAGTYKCVANN 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bdl	NP_608822.1	IG_like	42..128	CDD:214653
		Ig	43..131	CDD:299845
		I-set	153..242	CDD:254352	26/106 (25%)
		Ig	157..242	CDD:299845	26/102 (25%)
		Ig_2	252..337	CDD:290606	22/91 (24%)
		IG_like	260..327	CDD:214653	17/73 (23%)
		I-set	341..428	CDD:254352	25/81 (31%)
		IGc2	356..419	CDD:197706	21/64 (33%)
		FN3	435..524	CDD:238020
		FN3	554..636	CDD:238020
ncam-1	NP_741709.1	IG	64..142	CDD:214652	22/81 (27%)
		Ig	69..140	CDD:143165	20/74 (27%)
		IG_like	153..236	CDD:214653	23/101 (23%)
		Ig	160..222	CDD:299845	17/70 (24%)
		IG_like	256..330	CDD:214653	21/67 (31%)
		IGc2	256..320	CDD:197706	21/67 (31%)
		IG_like	<445..499	CDD:214653
		Ig	<445..498	CDD:143165
		IG_like	520..596	CDD:214653
		IGc2	520..587	CDD:197706
		FN3	<652..701	CDD:238020
		FN3	<817..873	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10075
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100