DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bdl and rig-4

DIOPT Version :9

Sequence 1:	NP_608822.1	Gene:	bdl / 33635	FlyBaseID:	FBgn0028482	Length:	719	Species:	Drosophila melanogaster
Sequence 2:	NP_501339.2	Gene:	rig-4 / 177597	WormBaseID:	WBGene00004371	Length:	2325	Species:	Caenorhabditis elegans

Alignment Length:	734	Identity:	148/734 - (20%)
Similarity:	260/734 - (35%)	Gaps:	203/734 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 QTNLEAKVGSHVVFNCYIDFPFDAPIPYLVHWTKDNKKIFTWY--EQETSTSEL-----FNGRLH 97
            :|.:|:.:....:|:|...|           .:||:.:| .|:  .|:.|.||:     .|.|..
Worm   232 RTIIESTLPHDEIFDCVTSF-----------GSKDDVRI-RWFLNGQQISGSEVGMTTTLNNRRL 284

  Fly    98 LVENHPEFGRASVNLTAIRESDQGWYHCQVSFPNRSPSVRNNGTAYHLAVQGGSLIRIP-PVNQT 161
            ::.|...|.|....|....::..|             ...:..:||...:....|..:| .:.:|
Worm   285 IISNPSSFTRGEHKLECRADAAMG-------------RTSDQKSAYMTFISRPILKDLPNEIQKT 336

  Fly   162 IREGQTAFFHCVMKHPENSQASWYKDGVLLQEVQDLVRRFYMGPDGSLSIDPTMMSDLGEYECKV 226
            :  |.:....|.:|...:....|||:|:::...:           |.|:||.....|.|.|:|:.
Worm   337 V--GSSLSLKCSVKKKSSMDIKWYKNGLMMTTQR-----------GKLTIDRIKQDDFGLYQCEA 388

  Fly   227 RNSDG--------------------------------ELQT-----AKAFLN------------- 241
            .|:.|                                .::|     .|.|.|
Worm   389 TNAAGADLASVWVKEGEANETVATEMSEDGMSLEEEISMETPPPRKLKFFDNSKSQEQLFPFTSE 453

  Fly   242 IQYKAKVIYAPPEVFLPYGQPAV-LDCHFRANPPLKNLRWEKDGLLFDSYNVPGVFYKM-NGSLF 304
            ::...|:|..|.::.:..|...: ::|....:|| .|:.|..:|....:.||.   |.: |..|.
Worm   454 LEPSQKLIKTPKDLTVASGTDRIMMECAATGSPP-PNIIWLLNGHEIQTDNVK---YDLTNDGLA 514

  Fly   305 FAKVDENHAGSYTCTPYNDLGTDGPSPVISVIVLRPPIFSVTPKAIYIQK--LGEAAELPCEAID 367
            ...:.::..|.|||    ::.........:|.|....:....|..   ||  :|...|..|| :.
Worm   515 IHDIRKSDEGEYTC----EISGSNVKATANVQVNGDSLIEYGPAD---QKSLIGTNVEFSCE-VA 571

  Fly   368 RDGNNRPSIIWGRKDGQPLPAD-----RFSLS-GGNLTITGLVEGDRGIYECSATNEAATITAEA 426
            ::...:.|:.|...| ..||.:     |.|.: .|:|.|..:...:.|.|.|..|.:.....|.|
Worm   572 KEYVRKASVEWYLND-VLLPVNGNSGLRISRNRKGSLIIRQVGPDNTGEYRCRVTVDGREENASA 635

  Fly   427 ELMIENIAPRAPYNLTA---NSTETC-ITIRWQPGY--LRPNLEYTVWYRLMEAP-----EWRTL 480
            .|.|.. .|..|..:.|   |.|... :.:||..|:  ..|.:::.:..|.| .|     :|.|
Worm   636 MLQIIE-KPAMPERVRAELHNETMPAKVRVRWNEGFDGNEPIIKHAIEMRTM-GPTGLWSDWTT- 697

  Fly   481 RVLD-------KKVMEATVQHLQPGKEYEFMVLSQDKYGDGMFSKQFRFQTLPSPIRADDFDAQQ 538
             .:|       |......::.|:|....||.|::.:|:|.|..|......|:|          ||
Worm   698 -AIDNIPKEEGKPCCWTDIEDLRPSSTAEFRVVASNKHGPGKPSLPSYSVTMP----------QQ 751

  Fly   539 LQHDLGQVTAPAGGLGAPWNLTAIS-NQQGWLLHWEHPVQGLEG--LRLYAVRW---------W- 590
                     .|:   .||.|:.|.: :....::.|:.|.:.|:.  :..|.||:         |
Worm   752 ---------PPS---AAPRNVAASARSPHSVMVQWQQPKEELDSGDVLGYVVRYRLAGYSSLTWN 804

  Fly   591 ------KEPEHFLIGHAETFDNYYQLRHLKEDTLFKVQV-------LAVGTETQQSVPSHELLID 642
                  |:..:.|:....|:..|            ::||       |.|.:|:.:...|......
Worm   805 EKNLTTKDARNTLVDELITWREY------------EIQVAAYNKRGLGVFSESIEVTTSEGRPTQ 857

  Fly   643 VPSQRKVRALIIGSSVGVI 661
            .|  :.||..::.|:...|
Worm   858 AP--KNVRVKVLNSTAVAI 874

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bdl	NP_608822.1	IG_like	42..128	CDD:214653	19/92 (21%)
		Ig	43..131	CDD:299845	19/94 (20%)
		I-set	153..242	CDD:254352	23/139 (17%)
		Ig	157..242	CDD:299845	22/134 (16%)
		Ig_2	252..337	CDD:290606	18/86 (21%)
		IG_like	260..327	CDD:214653	16/68 (24%)
		I-set	341..428	CDD:254352	23/94 (24%)
		IGc2	356..419	CDD:197706	18/68 (26%)
		FN3	435..524	CDD:238020	25/106 (24%)
		FN3	554..636	CDD:238020	20/107 (19%)
rig-4	NP_501339.2	IG_like	330..402	CDD:214653	19/84 (23%)
		IGc2	338..393	CDD:197706	16/65 (25%)
		I-set	459..543	CDD:254352	20/91 (22%)
		IGc2	478..534	CDD:197706	15/63 (24%)
		IG_like	553..639	CDD:214653	24/90 (27%)
		Ig	564..635	CDD:143165	18/72 (25%)
		FN3	643..747	CDD:238020	25/106 (24%)
		FN3	756..850	CDD:238020	20/105 (19%)
		FN3	858..954	CDD:238020	5/19 (26%)
		FN3	959..1042	CDD:238020
		FN3	1057..1151	CDD:238020
		FN3	1156..1251	CDD:238020
		FN3	1258..1356	CDD:238020
		FN3	1361..1453	CDD:238020
		FN3	1464..1560	CDD:238020
		FN3	1572..1664	CDD:238020
		FN3	1679..1764	CDD:238020
		FN3	1774..1858	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	48	1.000	Domainoid score	I8024
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.900