DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bdl and Dscam

DIOPT Version :9

Sequence 1:	NP_608822.1	Gene:	bdl / 33635	FlyBaseID:	FBgn0028482	Length:	719	Species:	Drosophila melanogaster
Sequence 2:	XP_038943864.1	Gene:	Dscam / 171119	RGDID:	619992	Length:	2034	Species:	Rattus norvegicus

Alignment Length:	726	Identity:	167/726 - (23%)
Similarity:	261/726 - (35%)	Gaps:	214/726 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 PIPYLVHWTKDNKKIFTWYEQETSTSELFNGRLHLVENHPEFGRASVNLTAIRESDQGWYHCQVS 128
            |:| .|.||.|:..|.......  .|::.....::|        :.:|:::.:..|.|.|.|..
  Rat   434 PLP-TVTWTLDDDPILKGSGHR--ISQMITSEGNVV--------SYLNISSSQVRDGGVYRCTA- 486

  Fly   129 FPNRSPSVRNNGTAY--HLAVQGGSLIRIPPVNQTIREGQTAFFHC-VMKHPENSQASWYKDGVL 190
              |.|..|    ..|  .:.|:|.:.|| |..|.|...|:..:.|| |:.:|..| ..|||:..|
  Rat   487 --NNSAGV----VLYQARINVRGPASIR-PMKNITAIAGRDTYIHCRVIGYPYYS-IKWYKNANL 543

  Fly   191 LQEVQDLVRRFYMGPDGSLSI-DPTMMSDLGEYECKVRNSDGELQTAKAFLNIQYKAKVIYAPPE 254
            |....   |:.....:|:|.: |.....|.|||.|.|. ...:|.|::   ::....||    |.
  Rat   544 LPFNH---RQVAFENNGTLKLSDVQKEVDEGEYTCNVL-VQPQLSTSQ---SVHVTVKV----PP 597

  Fly   255 VFLPY-------GQPAVLDCHFRANPPLKNLRWEKD--------GLLFDSYNVPGVFYKMNGSLF 304
            ...|:       ||...:.|...:......:.|:||        |:..|:.:       ...||.
  Rat   598 FIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPASLGVTIDNID-------FTSSLR 655

  Fly   305 FAKVDENHAGSYTCTPYND-LGTDGPSPVISVIVLRPPIFSVTPK---AIYIQKLGEAAELPCEA 365
            .:.:...|.|:|||...|: ...:..|   .:||..||.|.|.|:   .||    |:|..|.|.|
  Rat   656 ISNLSLMHNGNYTCIARNEAAAVEHQS---QLIVRVPPKFVVQPRDQDGIY----GKAVILNCSA 713

  Fly   366 IDRDGNNRPSIIWGRKDGQPLPADRFS----------LSGGNLTITGLVEGDRGIYECSATNEA- 419
               :|...|:|:|....|..:|  :|.          ||.|:|.|..:||.|.|.|.|..:|:.
  Rat   714 ---EGYPVPTIVWKFSKGAGVP--QFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVG 773

  Fly   420 --------------ATITAEAELMIENIAPRAPYNLTANSTETCITIRW--QPGYLRPNL-EYTV 467
                          |.||:.....:.....|...:.||:. |..|.:||  :...:.|.: .|.|
  Rat   774 ADVSKSMYLTVKIPAMITSYPNTTLATQGQRKEMSCTAHG-EKPIIVRWEKEDRIINPEMARYLV 837

  Fly   468 WYRLMEAPEWRTLRVL--------------------DKKVMEATVQHLQPGKEYEFMVLSQDKYG 512
            ..:.:......||::|                    |:.:::.|||......|.|.
  Rat   838 STKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEI--------- 893

  Fly   513 DGMFSKQFRFQTLP----------SPI---------RADDFDAQQLQHD----LGQVTA----PA 550
                 |..:.:|:.          |||         ::|.:|:.|...|    |...|.    |:
  Rat   894 -----KDVKARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPS 953

  Fly   551 G------------GLGAPWNLTAISNQQGWLLHWEHPVQ--GLEGLRLYAVR-WWKEPEHFL--- 597
            .            |...|.|...|:..:.   ..:.|.|  .||.....::| .||.|:..|
  Rat   954 STYSIRMYAKNRIGKSEPSNEITITADEA---APDGPPQEVHLEPTSSQSIRVTWKAPKKHLQNG 1015

  Fly   598 ------IGHAE--TFDNY---------------YQLRHLKEDTLFKVQVLA-----VGTETQQSV 634
                  ||:.|  |..|:               |.|.:|.:.|.:.:.|.|     .|..:|:.:
  Rat  1016 IIRGYQIGYREYSTGGNFQFNIISIDTTGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEII 1080

  Fly   635 PSHELLIDVPS 645
            .:  .|.||||
  Rat  1081 TT--TLEDVPS 1089

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bdl	NP_608822.1	IG_like	42..128	CDD:214653	14/63 (22%)
		Ig	43..131	CDD:299845	14/66 (21%)
		I-set	153..242	CDD:254352	28/90 (31%)
		Ig	157..242	CDD:299845	25/86 (29%)
		Ig_2	252..337	CDD:290606	19/100 (19%)
		IG_like	260..327	CDD:214653	16/75 (21%)
		I-set	341..428	CDD:254352	33/114 (29%)
		IGc2	356..419	CDD:197706	24/72 (33%)
		FN3	435..524	CDD:238020	20/111 (18%)
		FN3	554..636	CDD:238020	25/115 (22%)
Dscam	XP_038943864.1	Ig	26..121	CDD:416386
		Ig strand A'	33..37	CDD:409353
		Ig strand B	40..49	CDD:409353
		Ig strand C	55..61	CDD:409353
		Ig strand C'	63..66	CDD:409353
		Ig strand D	72..75	CDD:409353
		Ig strand E	80..85	CDD:409353
		Ig strand F	98..106	CDD:409353
		Ig strand G	109..121	CDD:409353
		Ig	125..210	CDD:416386
		Ig strand A	126..130	CDD:409353
		Ig strand A'	132..136	CDD:409353
		Ig strand B	139..149	CDD:409353
		Ig strand C	157..163	CDD:409353
		Ig strand C'	164..167	CDD:409353
		Ig strand E	179..185	CDD:409353
		Ig strand F	191..201	CDD:409353
		IGc2	239..300	CDD:197706
		Ig strand B	242..246	CDD:409353
		Ig strand C	255..259	CDD:409353
		Ig strand F	290..295	CDD:409353
		Ig	313..395	CDD:416386
		Ig strand A	314..319	CDD:409353
		Ig strand A'	322..326	CDD:409353
		Ig strand B	329..339	CDD:409353
		Ig strand C	344..350	CDD:409353
		Ig strand C'	351..354	CDD:409353
		Ig strand E	368..374	CDD:409353
		Ig strand F	381..389	CDD:409353
		Ig	406..501	CDD:416386	18/84 (21%)
		Ig strand A	406..409	CDD:409353
		Ig strand A'	415..419	CDD:409353
		Ig strand B	422..431	CDD:409353
		Ig strand C	436..442	CDD:409353	3/6 (50%)
		Ig strand C'	444..447	CDD:409353	0/2 (0%)
		Ig strand D	452..460	CDD:409353	1/9 (11%)
		Ig strand E	464..473	CDD:409353	2/16 (13%)
		Ig strand F	480..488	CDD:409353	3/10 (30%)
		Ig strand G	491..501	CDD:409353	2/13 (15%)
		Ig	504..593	CDD:416386	28/97 (29%)
		Ig strand A	505..507	CDD:409353	0/1 (0%)
		Ig strand A'	512..516	CDD:409353	2/3 (67%)
		Ig strand B	519..526	CDD:409353	1/6 (17%)
		Ig strand C	533..539	CDD:409353	2/6 (33%)
		Ig strand C'	540..542	CDD:409353	0/1 (0%)
		Ig strand D	549..553	CDD:409353	1/3 (33%)
		Ig strand E	557..563	CDD:409353	2/5 (40%)
		Ig strand F	571..579	CDD:409353	5/8 (63%)
		Ig strand G	583..593	CDD:409353	2/12 (17%)
		Ig	596..686	CDD:416386	19/99 (19%)
		Ig strand A	597..599	CDD:409353	0/1 (0%)
		Ig strand B	611..620	CDD:409353	2/8 (25%)
		Ig strand C	625..632	CDD:409353	1/6 (17%)
		Ig strand C'	634..636	CDD:409353	0/1 (0%)
		Ig strand D	643..648	CDD:409353	1/4 (25%)
		Ig strand E	651..658	CDD:409353	2/6 (33%)
		Ig strand F	665..673	CDD:409353	4/7 (57%)
		Ig strand G	676..685	CDD:409353	1/11 (9%)
		Ig_DSCAM	689..784	CDD:409397	31/103 (30%)
		Ig strand B	707..711	CDD:409397	1/3 (33%)
		Ig strand C	720..724	CDD:409397	1/3 (33%)
		Ig strand E	749..753	CDD:409397	2/3 (67%)
		Ig strand F	763..768	CDD:409397	2/4 (50%)
		Ig strand G	777..780	CDD:409397	0/2 (0%)
Ig_DSCAM	785..884	CDD:409398	19/99 (19%)
Ig strand B	805..809	CDD:409398	0/3 (0%)
Ig strand C	818..822	CDD:409398	1/3 (33%)
Ig strand E	848..852	CDD:409398	2/3 (67%)
Ig strand F	862..867	CDD:409398	0/4 (0%)
Ig strand G	875..878	CDD:409398	0/2 (0%)
FN3	885..978	CDD:238020	17/106 (16%)
FN3	986..1083	CDD:238020	22/98 (22%)
FN3	1091..1184	CDD:238020
FN3	1189..1278	CDD:238020
Ig_3	1287..1363	CDD:404760
Ig strand B	1303..1307	CDD:409353
Ig strand C	1316..1320	CDD:409353
Ig strand E	1342..1346	CDD:409353
Ig strand F	1356..1361	CDD:409353
FN3	1380..1470	CDD:238020
FN3	1486..1555	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10075
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910