DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bdl and Dscaml1

DIOPT Version :9

Sequence 1:	NP_608822.1	Gene:	bdl / 33635	FlyBaseID:	FBgn0028482	Length:	719	Species:	Drosophila melanogaster
Sequence 2:	NP_001074739.2	Gene:	Dscaml1 / 114873	MGIID:	2150309	Length:	2053	Species:	Mus musculus

Alignment Length:	688	Identity:	160/688 - (23%)
Similarity:	251/688 - (36%)	Gaps:	151/688 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 RRQTNLEAKVGSHVVFNC-YIDFPFDAPIPYLVHWTKDNKKIFTWYEQETSTSELFNGRLHLVEN 101
            |...|:.|..|...:.|| .|.:|:     |.:.|.||                    .|.|.:|
Mouse   509 RAMRNITAVAGRDTLINCRVIGYPY-----YSIKWYKD--------------------ALLLPDN 548

  Fly   102 HPE--FGRASVNLTAIRES-DQGWYHCQVSF-PNRSPSVRNNGTAYHLAVQGGSLIRIPPVNQTI 162
            |.:  |...::.||.:::. |:|.|.|.|.. |..|.|     .:.|:||      ::||:.|..
Mouse   549 HRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSIS-----QSVHVAV------KVPPLIQPF 602

  Fly   163 R-----EGQTAFFHCVMKHPENS-QASWYKDG--VLLQEVQDLVRRFYMGPDGSLSIDPTMMSDL 219
            .     .||..:..||:...:.. :.:|.|||  ::......:..:.:|   .||.|....:...
Mouse   603 EFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFM---SSLQISSVSLKHN 664

  Fly   220 GEYECKVRNSDGELQTAKAFLNIQYKAKVIYAPPE-VFLP------YGQPAVLDCHFRANPPLKN 277
            |.|.|...|:...:...:..        ::..||. |..|      ||:..||:|.....||.|
Mouse   665 GNYTCIASNAAATVSRERQL--------IVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPK- 720

  Fly   278 LRWEK---DGLLFDSYNVP---GVFYKMNGSLFFAKVDENHAGSYTCTPYNDLGTDGPSPVISVI 336
            :.|:.   .|.....:.||   .:....|.||....|.|...|.|.|...|.:||| .|..:.:.
Mouse   721 VMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTD-ISKAMFLT 784

  Fly   337 VLRPPIFSVTPKAIYIQKLGEAAELPCEAIDRDGNNRPSIIWGRKDGQPLPADRF------SLSG 395
            |..|.:.:..|......| |...||.|.|    ...||.||...|....:..||.      :...
Mouse   785 VKIPAMITSHPNTTIAIK-GHPKELNCTA----RGERPIIIRWEKGDTVIDPDRVMRYAIATKDN 844

  Fly   396 GNLTITGLV-----EGDRGIYECSATNEAATITAEAELMIENIAPRAPYNLTANSTET-CITIRW 454
            |:..::.|.     .||...:.|.|.|.........:|.::.  |..|..|.....:. .:.:||
Mouse   845 GDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQE--PPDPPELEIREVKARSMNLRW 907

  Fly   455 Q---------PGYLRPNLEYTVWYRLMEAPEW---RTLRVLDKKVMEATVQHLQPGKEYEFMVLS 507
            .         .|:   ::||.     .::..|   ::.|.:...:.:|.:..|.|...|...:.|
Mouse   908 TQRFDGNSIITGF---DIEYK-----NKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYS 964

  Fly   508 QDKYGDGMFSKQFRFQTLPSPIRADDFDAQQLQHDLGQVTAPAGGLGAPWNLTAIS-NQQGWLLH 571
            .:|.|....||:....|                    :..||.   |.|.::|... ..|...:.
Mouse   965 FNKIGRSEPSKELTIST--------------------EEAAPD---GPPMDVTLQPVTSQSIQVT 1006

  Fly   572 WEHPVQGLEG--LRLYAVRWWKEP-----EHFLIGHAETFDN-YYQLRHLKEDTLFKVQVLA--- 625
            |:.|.:.|:.  :|.|.:.:.:..     ::.::....|.|: .|.|.:||:...:.|.|.|
Mouse  1007 WKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNR 1071

  Fly   626 VGTETQQSVPSHELLIDVPSQ--RKVRALIIGSSVGVI 661
            .||....|..:...|.|||||  ..||||.|.|.|.||
Mouse  1072 AGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVI 1109

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bdl	NP_608822.1	IG_like	42..128	CDD:214653	22/89 (25%)
		Ig	43..131	CDD:299845	22/92 (24%)
		I-set	153..242	CDD:254352	19/96 (20%)
		Ig	157..242	CDD:299845	18/92 (20%)
		Ig_2	252..337	CDD:290606	29/97 (30%)
		IG_like	260..327	CDD:214653	21/72 (29%)
		I-set	341..428	CDD:254352	21/97 (22%)
		IGc2	356..419	CDD:197706	19/73 (26%)
		FN3	435..524	CDD:238020	19/101 (19%)
		FN3	554..636	CDD:238020	21/93 (23%)
Dscaml1	NP_001074739.2	IGc2	43..110	CDD:197706
		Ig	125..218	CDD:353325
		I-set	226..311	CDD:336764
		Ig_3	317..389	CDD:339005
		Ig	408..498	CDD:353325
		IGc2	519..577	CDD:197706	20/82 (24%)
		Ig	615..681	CDD:319273	14/68 (21%)
		Ig_DSCAM	707..785	CDD:143211	23/79 (29%)
		Ig	803..891	CDD:353325	21/93 (23%)
		FN3	887..981	CDD:238020	19/101 (19%)
		FN3	988..1085	CDD:238020	21/96 (22%)
		FN3	1093..1186	CDD:238020	9/17 (53%)
		FN3	1191..1282	CDD:238020
		Ig	1307..1377	CDD:319273
		FN3	1384..1474	CDD:238020
		FN3	1488..1560	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1716..1741
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1773..1803
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1840..1862
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1974..2053
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10075
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910