DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bdl and igsf9

DIOPT Version :9

Sequence 1:	NP_608822.1	Gene:	bdl / 33635	FlyBaseID:	FBgn0028482	Length:	719	Species:	Drosophila melanogaster
Sequence 2:	NP_001090640.1	Gene:	igsf9 / 100036605	XenbaseID:	XB-GENE-989817	Length:	1423	Species:	Xenopus tropicalis

Alignment Length:	845	Identity:	223/845 - (26%)
Similarity:	329/845 - (38%)	Gaps:	219/845 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 ILLMNISCTSAARDHRRQTNLEAKVGSHVVFNCYIDFPFDAPIP--YLVHWTKDNKKI-----FT 80
            :|::...|.:.|.....|| :..:||...|..|.: ...||..|  |::.|.:....:     |.
Frog     9 VLILFSCCINGAIRSDSQT-VVGRVGESTVLGCSL-LHQDAGRPPLYVIEWVRFGFMLPIFIKFG 71

  Fly    81 WYEQETSTSELFNGRLHLVENHPEFGRASVNLTAIRESDQGWYHCQVSFPNRSPSVRN--NGTAY 143
            .|........|  ||..:.|.      ||:::.::|..|||||.|:|.|.:|.....:  |||..
Frog    72 LYSPRVDPQYL--GRTRIEEG------ASLHIESLRSEDQGWYECRVLFLDRHHGEEDFQNGTWV 128

  Fly   144 HLA-------------------------------------------------------------- 146
            ||.
Frog   129 HLTVNSPPSFRETPPTYVEVRVGDTLTLTCVAYGNPQPVVTWKRDGVTLESGDKVQASNGSLSIV 193

  Fly   147 ----------------------------VQGGSLIRIPPVNQTIREGQTAFFHCVMK-HPENSQA 182
                                        |||..:|.:||.|.|:...|.||..|..: :|.|...
Frog   194 GVERGNAGVYTCHAFSDEGEVTHTSRVLVQGPPIIVVPPENTTVNVSQDAFLTCQAEAYPANLTY 258

  Fly   183 SWYKDG---VLLQEVQDLVRRFYMGPDGSLSIDPTMMSDLGEYECKVRNSDGELQTAKAFLNIQY 244
            :|::..   .||..:|..||...   |||..|......|.|:|.|...|...:..:|.|:|.:.:
Frog   259 TWFQGSNNVFLLNRLQPRVRILV---DGSFLIQRVTPEDAGKYTCIPSNGMWKSPSASAYLTVLH 320

  Fly   245 KAKVIYAPPEVFLPYGQPAVLDCHFRANPPLKNLRWEKDG--LLFDSYNVPGVFYKMNGSLFFAK 307
            .|.|...|.|.:||.|...|:.|..||||||..:.|.|||  |..|.|  ||.:...:|||..|.
Frog   321 PAYVTSMPAETYLPIGMRGVIKCPVRANPPLLLVNWTKDGHALELDKY--PGWYVDEDGSLVIAT 383

  Fly   308 VDENHAGSYTCTPYNDLGTDGPSPVISVIVLRPPIFSVTPKAIYIQKLGEAAELPCEAIDRDGNN 372
            .:::..|.|||||||..||.|.|....||:..||.|...|...|.|.:|....:||.|:   |:.
Frog   384 GNDDALGIYTCTPYNSYGTGGVSLPTEVILKEPPSFIDVPSEEYFQDVGRELVIPCSAV---GDP 445

  Fly   373 RPSIIWGRKDGQPLPADRFSLSGGNLTITGLVEGDRGIYECSATNEAATITAEAELMIENIAPRA 437
            .|.|.|. |.|.|..:.....:..:|....|.:.:.||:||||||..|||:|...:.:...:|.|
Frog   446 PPLIRWS-KLGLPGKSAAQMDANSSLVFRPLTKEEHGIWECSATNHVATISARTAIYVLGTSPHA 509

  Fly   438 PYNLTANSTETCITIRWQP----GYLRPNLEYTVWYRLMEAP----------EWRTLRVLDKKVM 488
            ..|::|.|..:.:.:.|:|    ||.:   .::|||    ||          :|.:|    ...:
Frog   510 VTNISALSLVSSVNVSWEPGFDGGYFQ---RFSVWY----APLVKRLTRGHHDWISL----SAAV 563

  Fly   489 EAT---VQHLQPGKEYEFMVLSQDKYGDGMFSK-------QFRFQTLPSPIRADDFDAQQLQHDL 543
            .||   |.:||....|:|.:|||:|.|.|.||:       .|...|:|.|:...:
Frog   564 GATHLLVGNLQADTAYQFSILSQNKLGTGPFSEIVTATPLNFPVTTVPPPVPTSE---------- 618

  Fly   544 GQVTAPAGGLGAPWNLTAISNQQGWLLHWEHPVQGLEGLRLYAVRWWKEPEHFLIGHAETFDNYY 608
                 |:..|..|..|:|....:|..|.|..|::....||.|.:.:.::.     |..|..|...
Frog   619 -----PSDSLSPPRYLSANETSEGVFLQWLPPLRSSLPLRGYGLEFRRDE-----GAWELLDESI 673

  Fly   609 Q-------LRHLKEDTLFKVQVLA--------------VGTETQQSVPSHELLIDVPSQRKVRAL 652
            .       :|.|.:||:::.:::|              |.||..:..||..|..:|  |||  .|
Frog   674 PESQTELVVRKLVKDTMYEFRLVAFAGDYISEPSNSVNVSTEGMKVYPSKTLNPEV--QRK--PL 734

  Fly   653 IIGSSVGVIFL-----LCALCAFLYVKRSCLRHL----------FAKDSSASEDEDTAESGDCDS 702
            :.|...|..||     |..:.|.:..:|...|.|          |::...||..:::..|...||
Frog   735 LAGVVGGACFLSLTIILSTVVACMMNRRRARRRLKRRQQDTPMVFSQPKKASPSQNSNGSNSPDS 799

Fly 703 702
Frog 800 799

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bdl	NP_608822.1	IG_like	42..128	CDD:214653	24/92 (26%)
		Ig	43..131	CDD:299845	26/94 (28%)
		I-set	153..242	CDD:254352	29/92 (32%)
		Ig	157..242	CDD:299845	27/88 (31%)
		Ig_2	252..337	CDD:290606	39/86 (45%)
		IG_like	260..327	CDD:214653	31/68 (46%)
		I-set	341..428	CDD:254352	30/86 (35%)
		IGc2	356..419	CDD:197706	21/62 (34%)
		FN3	435..524	CDD:238020	32/112 (29%)
		FN3	554..636	CDD:238020	21/102 (21%)
igsf9	NP_001090640.1	Ig	25..132	CDD:299845	34/116 (29%)
		IG_like	25..110	CDD:214653	26/94 (28%)
		I-set	136..222	CDD:254352	0/85 (0%)
		IGc2	151..212	CDD:197706	0/60 (0%)
		Ig_2	226..318	CDD:290606	29/94 (31%)
		I-set	226..318	CDD:254352	29/94 (31%)
		IG_like	328..407	CDD:214653	37/80 (46%)
		Ig	340..402	CDD:299845	29/63 (46%)
		IG_like	431..502	CDD:214653	25/74 (34%)
		Ig	439..502	CDD:299845	23/66 (35%)
		FN3	507..601	CDD:238020	31/104 (30%)
		FN3	624..714	CDD:238020	19/94 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	84	1.000	Domainoid score	I8118
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D151368at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010