DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Art2 and PRMT9

DIOPT Version :9

Sequence 1:	NP_001285600.1	Gene:	Art2 / 33631	FlyBaseID:	FBgn0031592	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_612373.2	Gene:	PRMT9 / 90826	HGNCID:	25099	Length:	845	Species:	Homo sapiens

Alignment Length:	355	Identity:	95/355 - (26%)
Similarity:	155/355 - (43%)	Gaps:	75/355 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ELAKDDE---KMDGNHT--------------DANQIIKDRRRQEEHYFKLYGRIEIHEW---LLK 48
            ||..|||   ...|.|.              .|.::..|....:|:::::...: :..|   :|.
Human    95 ELFPDDEVICNSMGEHLFRMGFRDEAAGYFHKAVKLNPDFSDAKENFYRVANWL-VERWHFIMLN 158

  Fly    49 DSVRIKAYREAIQHNEFFRHKTVLDVGCGMGVLSMFAAKAGSKRVLAVE-AATISEFAQQVVQDN 112
            |:.|...|..|||.......|:|||:|.|.|:|||||.|||:..|.|.| :.|:.|.|..||..|
Human   159 DTKRNTIYNAAIQKAVCLGSKSVLDIGAGTGILSMFAKKAGAHSVYACELSKTMYELACDVVAAN 223

  Fly   113 EFGRVIQVIQGKVEDIELPDGI-KKVDIIVCDWMGSCLFSGNMLESLLFA--------RDKWLSA 168
            :....|:::..|..|||:|..| ::|.::|.:.:.:.||...::|||:.|        :.|..||
Human   224 KMEAGIKLLHTKSLDIEIPKHIPERVSLVVTETVDAGLFGEGIVESLIHAWEHLLLQPKTKGESA 288

  Fly   169 T----GHIYPDTAQLYLAAIK----GRDQDLGFWHDVHGFDL-------SAIRRRCESKAVVEHV 218
            .    |.:.|.:|.::..|::    .|...:|. .|:.|..|       |......:::..:|..
Human   289 NCEKYGKVIPASAVIFGMAVECAEIRRHHRVGI-KDIAGIHLPTNVKFQSPAYSSVDTEETIEPY 352

  Fly   219 TGDQMMSRV-----CLVKSLDLYTEPRQSAKSRSLFELK-------------VSRNGWVHGLVAY 265
            |.:: ||||     .|.:..::.|     ....:|.|||             |.:.|.:..::.:
Human   353 TTEK-MSRVPGGYLALTECFEIMT-----VDFNNLQELKSLATKKPDKIGIPVIKEGILDAIMVW 411

  Fly   266 FDVGFSKSTQRISFSTSPSAPWTHWNQTVF 295
            |.:   :.....|.|||||.. |.|.|.|:
Human   412 FVL---QLDDEHSLSTSPSEE-TCWEQAVY 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Art2	NP_001285600.1	AdoMet_MTases	70..>150	CDD:100107	32/81 (40%)
PRMT9	NP_612373.2	TPR 1	25..58
		TPR	<39..144	CDD:223533	10/48 (21%)
		TPR 2	67..100		2/4 (50%)
		TPR repeat	68..95	CDD:276809	95/355 (27%)
		TPR repeat	100..130	CDD:276809	5/29 (17%)
		TPR 3	101..134		4/32 (13%)
		AdoMet_MTases	148..>303	CDD:327401	53/155 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142485
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0500
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740