DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Art2 and CARM1

DIOPT Version :9

Sequence 1:	NP_001285600.1	Gene:	Art2 / 33631	FlyBaseID:	FBgn0031592	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_954592.1	Gene:	CARM1 / 10498	HGNCID:	23393	Length:	608	Species:	Homo sapiens

Alignment Length:	346	Identity:	119/346 - (34%)
Similarity:	185/346 - (53%)	Gaps:	33/346 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 HTDANQIIKDRRRQEE--HYFKLYGRIEIHEWLLKDSVRIKAYREAI-QHNEFFRHKTVLDVGCG 77
            ||....:..:|..:..  .||:.||.:...:.:::|.||...|:.|| |::..|:.|.|||||||
Human   130 HTLERSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCG 194

  Fly    78 MGVLSMFAAKAGSKRVLAVEAATISEFAQQVVQDNEFGRVIQVIQGKVEDIELPDGIKKVDIIVC 142
            .|:||.|||:||::::.||||:|:::.|:.:|:.|.....|.||.||||::.||:   :||||:.
Human   195 SGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPE---QVDIIIS 256

  Fly   143 DWMGSCLFSGNMLESLLFARDKWLSATGHIYPDTAQLYLAAIKGRDQDL--------GFWH--DV 197
            :.||..||:..||||.|.|: |:|..:|:::|....::||..  .|:.|        .||:  ..
Human   257 EPMGYMLFNERMLESYLHAK-KYLKPSGNMFPTIGDVHLAPF--TDEQLYMEQFTKANFWYQPSF 318

  Fly   198 HGFDLSAIRRRCESKAVVEHV---TGDQMMSRVCLVKSLDLYTEPRQSAKSRSL------FELKV 253
            ||.||||:|    ..||.|:.   ..|....|:.:.||:. ||.....||...|      |:..:
Human   319 HGVDLSALR----GAAVDEYFRQPVVDTFDIRILMAKSVK-YTVNFLEAKEGDLHRIEIPFKFHM 378

  Fly   254 SRNGWVHGLVAYFDVGFSKSTQRISFSTSPSAPWTHWNQTVFYLETPLPVRAGECIKGVLTMKPS 318
            ..:|.||||..:|||.|..|...:..||:|:.|.|||.|.....::||..:||:.:.|...:..:
Human   379 LHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIAN 443

  Fly   319 EDSIFDTEFDIFVNFDGREKS 339
            :...:|......|:..|.:.|
Human   444 KRQSYDISIVAQVDQTGSKSS 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Art2	NP_001285600.1	AdoMet_MTases	70..>150	CDD:100107	38/79 (48%)
CARM1	NP_954592.1	CARM1	34..138	CDD:288395	2/7 (29%)
		PRMT5	<172..435	CDD:282971	104/273 (38%)
		Methyltransf_18	184..283	CDD:289607	49/102 (48%)
		Transactivation domain. /evidence=ECO:0000250	499..608
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142486
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0500
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D840669at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750