Protein Alignment Art2 and PRMT3

DIOPT Version :10

• Sequence 1: NP_608821.1
• Gene: Art2 / 33631
• FlyBaseID: FBgn0031592
• Length: 355
• Species: Drosophila melanogaster
• Sequence 2: NP_005779.1
• Gene: PRMT3 / 10196
• HGNCID: 30163
• Length: 531
• Species: Homo sapiens
• Alignment Length: 340
• Identity: 129/340 - (37%)
• Similarity: 199/340 - (58%)
• Gaps: 29/340 - (8%)

  Fly    16 HTD------ANQIIKDRRRQEEH-YFKLYGRIEIHEWLLKDSVRIKAYREAIQHN-EFFRHKTVL 72
            |||      :..:|.|.:..|:. ||..||...|||.:|||.:|.::||:.|..| ..|:.|.||
Human   196 HTDVRTCSSSTSVIADLQEDEDGVYFSSYGHYGIHEEMLKDKIRTESYRDFIYQNPHIFKDKVVL 260

  Fly    73 DVGCGMGVLSMFAAKAGSKRVLAVEAATISEFAQQVVQDNEFGRVIQVIQGKVEDIELPDGIKKV 137
            |||||.|:|||||||||:|:||.|:.:.|...|..:::.|:....|.:|:||:|::.||  ::||
Human   261 DVGCGTGILSMFAAKAGAKKVLGVDQSEILYQAMDIIRLNKLEDTITLIKGKIEEVHLP--VEKV 323

  Fly   138 DIIVCDWMGSCLFSGNMLESLLFARDKWLSATGHIYPDTAQLYLAAI----KGRDQDLGFWHDVH 198
            |:|:.:|||..|...:||:|:|:|::|:|:..|.:|||...:.|.|:    |..|: :.||.||:
Human   324 DVIISEWMGYFLLFESMLDSVLYAKNKYLAKGGSVYPDICTISLVAVSDVNKHADR-IAFWDDVY 387

  Fly   199 GFDLSAIRRRCESKAVVEHVTGDQMMSRVCLVKSLDLYTEPRQSAKSRSLFELKVSRNGWVHGLV 263
            ||.:|.:::....:||||.:....::|..|.:|.:|.:|......:..|.|.||::|......:.
Human   388 GFKMSCMKKAVIPEAVVEVLDPKTLISEPCGIKHIDCHTTSISDLEFSSDFTLKITRTSMCTAIA 452

  Fly   264 AYFDVGFSKST-QRISFSTSPSAPWTHWNQTVFYLETPLPVRAGECIKGVLTMKPSEDSIFDTEF 327
            .|||:.|.|:. .|:.|||.|.:..|||.||||.||.|..|:|||.:||.:|:..::.
Human   453 GYFDIYFEKNCHNRVVFSTGPQSTKTHWKQTVFLLEKPFSVKAGEALKGKVTVHKNKK------- 510

  Fly   328 DIFVNFDGREKSVTI 342
                  |.|..:||:
Human   511 ------DPRSLTVTL 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Art2	NP_608821.1	COG4076	39..>204	CDD:443253	73/169 (43%)
PRMT3	NP_005779.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..43
		Interaction with ZNF200. /evidence=ECO:0000269|PubMed:39513743	48..71
		zf-C2H2_2	50..>99	CDD:463690
		Mediates interaction with ALDH1A1. /evidence=ECO:0000269|PubMed:33495566	186..531		129/340 (38%)
		COG4076	230..>393	CDD:443253	72/165 (44%)