Protein Alignment HTR7 and mAChR-C

DIOPT Version :10

• Sequence 1: NP_062873.1
• Gene: HTR7 / 3363
• HGNCID: 5302
• Length: 479
• Species: Homo sapiens
• Sequence 2: NP_572358.1
• Gene: mAChR-C / 31626
• FlyBaseID: FBgn0029909
• Length: 371
• Species: Drosophila melanogaster
• Alignment Length: 401
• Identity: 103/401 - (25%)
• Similarity: 169/401 - (42%)
• Gaps: 87/401 - (21%)

Human    53 TASPAPTWD--APPD------------NASGCGEQI-----NYGRVEKVVIGSILTL-----ITL 93
            |:|.:|.||  :.|:            ||:....:|     ::|      .|.:|.|     :.:
  Fly     4 TSSSSPAWDYRSSPEALGVVPFLWQHQNATETPTEITLQATSFG------AGHLLWLAINAFLFV 62

Human    94 LTIAGNCLVVISVCFVKKLRQP-SNYLIVSLALADLSVAVAV---MPFVSVTDL--IGGKWIFGH 152
            |.:.||.|.:::|...:.||.. ||..|:|||::|..|.:|:   :.|...:|:  :.|..:...
  Fly    63 LILGGNILTIVAVRTCRHLRSVISNLFILSLAVSDFCVGLALPYHLVFYMGSDIGAMRGPCLLRF 127

Human   153 FFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPP 217
            |..       :..|..|::||..|::|||:.:...|.|......:....:|:..|.|.|.:.|.|
  Fly   128 FLL-------ICACCVSMLTLISIAVDRYIAVVYALHYRRYMTRRVAYSIIIFNWCLGALVALLP 185

Human   218 LFGW-----AQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPG 277
            :| |     ||....|:|...    ||........|.|....|..:|::|.:.|.|.|.:.:
  Fly   186 VF-WNRWPDAQACEFDEVLAP----GYIAGVITPGFVIIWICMFLVYWRIMREASKQALRLR--- 242

Human   278 FPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLP 342
                  .||:         ...:|...:..||.|.         :.|:...:..|:|.||:||||
  Fly   243 ------QSVV---------YNTDEATTMRNLLLHP---------DWKSVQIVVFIMGCFTLCWLP 283

Human   343 FFLLSTARPF-ICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQ-YRN 405
            :|.::.|:.| ||.:|.     .:.:|...|..|||.:||.||::.|...|..:...|.|: .|.
  Fly   284 YFCVAIAQLFSICQSSS-----MIYKTTFSLAIANSALNPIIYSWKNSGFRRAFVQTLCCRTARQ 343

Human   406 INRKLSAAGMH 416
            ...:|.|...|
  Fly   344 CEDQLPADSKH 354

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HTR7	NP_062873.1	7tmA_5-HT7	97..395	CDD:320452	83/309 (27%)
		TM helix 2	116..142	CDD:320452	10/28 (36%)
		TM helix 3	155..185	CDD:320452	8/29 (28%)
		TM helix 4	197..219	CDD:320452	6/21 (29%)
		TM helix 5	236..265	CDD:320452	7/28 (25%)
		TM helix 6	320..350	CDD:320452	10/29 (34%)
		TM helix 7	363..388	CDD:320452	9/24 (38%)
mAChR-C	NP_572358.1	7tm_classA_rhodopsin-like	53..325	CDD:410626	83/315 (26%)
		TM helix 1	53..78	CDD:410626	6/24 (25%)
		TM helix 2	86..111	CDD:410626	9/24 (38%)
		TM helix 3	123..153	CDD:410626	9/36 (25%)
		TM helix 4	166..185	CDD:410626	5/18 (28%)
		TM helix 5	204..229	CDD:410626	6/28 (21%)
		TM helix 6	261..291	CDD:410626	11/38 (29%)
		TM helix 7	300..325	CDD:410626	9/29 (31%)