DRSC/TRiP Functional Genomics Resources

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Protein Alignment ft and PCDHA1

DIOPT Version :10

Sequence 1:NP_477497.1 Gene:ft / 33627 FlyBaseID:FBgn0001075 Length:5147 Species:Drosophila melanogaster
Sequence 2:NP_061723.1 Gene:PCDHA1 / 56147 HGNCID:8663 Length:950 Species:Homo sapiens


Alignment Length:738 Identity:211/738 - (28%)
Similarity:328/738 - (44%) Gaps:118/738 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 RLLLLFFLLLAGRESLCQTGDTKLELLAPRGRSYATTYEQYAAFPRRRSSSSSPSGEMQSRAVDT 67
            |.|||:.||||..|    .|..:|....|....:.|       |..|               |..
Human    12 RDLLLWLLLLAAWE----VGSGQLHYSIPEEAKHGT-------FVGR---------------VAQ 50

  Fly    68 SADFEVLEGQPRGTTVGFIPTKPKFSYRFNEPPREFTLDPVTGEVKTNVVLDREGMRD------- 125
            ....|:.|         .:|...:.:.:.:....|..|.  .|.:..|..:|||.:..       
Human    51 DLGLELAE---------LVPRLFRVASKTHRDLLEVNLQ--NGILFVNSRIDREELCQWSAECSI 104

  Fly   126 HYDLVVLSSQPTYPIEVRIKVLDVNDNSPEFPEPSIAISFSESATSGTRLLLDAATDADVGENGV 190
            |.:|:  :.:|.....|.:||.|:|||.|.|......|...||....:|..::.|.|||:|.|.:
Human   105 HLELI--ADRPLQVFHVEVKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANAL 167

  Fly   191 TDQYEIVAGNVDNKFRLVTTANPSGDTSY-----------LHLETTGNLDRESRGSYQLNISARD 244
                            |..|.:||...|.           |.||....||||......|.::|.|
Human   168 ----------------LTYTLSPSDYFSLDVEASDELSKSLWLELRKYLDREETPELHLLLTATD 216

  Fly   245 GGSPPRFGYLQVNVTILDVNDNPPIFDHSDYNVSLNETALPGTPVVTVMASDNDLGDNSKITYYL 309
            ||.|...|.:::.:|:||||||.|:||.:.|.|.|.||...||.|.|:.|||.|.|.|.::.:..
Human   217 GGKPELQGTVELLITVLDVNDNAPLFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSF 281

  Fly   310 -----AETEHQFTVNPETGVISTTERVNCPQQTNVKSSASQKSCVFTVFARDHGSPRQDGRTYVT 369
                 .:.:.:|.|:..:|.|...::::..:         .||....|.|.|.|||.......|.
Human   282 DSGISRDIQEKFKVDSSSGEIRLIDKLDYEE---------TKSYEIQVKAVDKGSPPMSNHCKVL 337

  Fly   370 VNLLDTNDHDP--IISFRFFPDGGKVATVDENAVNGTVVAAVAVKDSDSGLNGRTSVRIVSGNEL 432
            |.:||.||:.|  .::..:.|       :.|:|...||:|.:.|.|.|||.||:.:..:     :
Human   338 VKVLDVNDNAPELAVTSLYLP-------IREDAPLSTVIALITVSDRDSGANGQVTCSL-----M 390

  Fly   433 GH--FRLEEA-ADLHIVRVNGVLDREEIGKYNLTVVAMDQGTPARTTTAHLIIDVNDVNDHEPVF 494
            .|  |:|... .:.:.:.::..||||.:..|.|.|.|.|.|:|:...||.:.::|.||||:.|.|
Human   391 PHVPFKLVSTFKNYYSLVLDSALDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDNAPAF 455

  Fly   495 EKSEYSAVLSELAPTGSFVASITATDEDTGVNAQVHYDILS---GNEL--KWFSMDPLTGLIVTT 554
            .:.||:..:.|..|.|..:.:::|.|.|...||.|.|.::.   |...  .:.|:...:|.:...
Human   456 AQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYAL 520

  Fly   555 GPLDREIRDTVELSISARDGGPNPKFAYTQLKVIILDENDEAPQFSQREQNVTLG--EDAPPQT- 616
            .|||.|..:.::..:||||.|..|..:...|:|.:|||||.||.........|:|  .:..|:. 
Human   521 QPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTIGAVSELVPRLV 585

  Fly   617 ----IVALMTATDHDQGTNGSVTFALAPSVERLYPLQFALDALTGQLTTRRPLDREKMSQYEISV 677
                :||.:.|.|.|.|.|..:::.|.|:.... .:.|.:...||:::|.|.||...:|:|.:.|
Human   586 GAGHVVAKVRAVDADSGYNAWLSYELQPAAGGA-RIPFRVGLYTGEISTTRVLDEADLSRYRLLV 649

  Fly   678 IARDQGAPTPQSATATVWLNVAD 700
            :.:|.|.|. .:|||||.:::.:
Human   650 LVKDHGEPA-LTATATVLVSLVE 671

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ftNP_477497.1 Cadherin_repeat 71..152 CDD:206637 18/87 (21%)
Cadherin_repeat 163..266 CDD:206637 34/113 (30%)
Cadherin_repeat 275..378 CDD:206637 32/107 (30%)
Cadherin_repeat 393..490 CDD:206637 32/99 (32%)
Cadherin_repeat 498..594 CDD:206637 30/100 (30%)
Cadherin_repeat 603..704 CDD:206637 30/105 (29%)
Cadherin_repeat 735..814 CDD:206637
Cadherin 843..>907 CDD:394985
Cadherin 950..1026 CDD:394985
Cadherin_repeat 1053..1149 CDD:206637
Cadherin_repeat 1157..1274 CDD:206637
Cadherin_repeat 1282..1380 CDD:206637
Cadherin_repeat 1390..1485 CDD:206637
Cadherin_repeat 1497..1597 CDD:206637
Cadherin_repeat 1621..1699 CDD:206637
Cadherin_repeat 1720..1818 CDD:206637
Cadherin_repeat 1827..1918 CDD:206637
Cadherin_repeat 1926..2023 CDD:206637
Cadherin_repeat 2031..2162 CDD:206637
Cadherin_repeat 2172..2274 CDD:206637
Cadherin_repeat 2282..2380 CDD:206637
Cadherin_repeat 2388..2487 CDD:206637
Cadherin_repeat 2495..2592 CDD:206637
Cadherin_repeat 2600..2694 CDD:206637
Cadherin_repeat 2710..2806 CDD:206637
Cadherin_repeat 2814..2909 CDD:206637
Cadherin_repeat 2917..3009 CDD:206637
Cadherin 3018..3114 CDD:394985
Cadherin 3129..3220 CDD:394985
Cadherin_repeat 3233..3330 CDD:206637
Cadherin_repeat 3338..3434 CDD:206637
Cadherin_repeat 3443..3541 CDD:206637
Cadherin_repeat 3550..3647 CDD:206637
Cadherin_repeat 3657..3753 CDD:206637
EGF 4017..4047 CDD:394967
EGF_CA 4056..4090 CDD:238011
EGF_CA 4094..4128 CDD:238011
Laminin_G_1 4156..4306 CDD:395008
LamG 4428..4543 CDD:238058
PCDHA1NP_061723.1 Cadherin_2 30..111 CDD:462413 18/115 (16%)
Cadherin_repeat 137..238 CDD:206637 34/116 (29%)
Cadherin_repeat 246..346 CDD:206637 32/108 (30%)
Cadherin_repeat 354..451 CDD:206637 33/108 (31%)
Cadherin_repeat 459..561 CDD:206637 31/101 (31%)
Cadherin_repeat 577..670 CDD:206637 28/94 (30%)
5 X 4 AA repeats of P-X-X-P 734..894
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 752..808
Cadherin_tail 800..916 CDD:435046
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 828..856
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 871..890
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 900..950
Blue background indicates that the domain is not in the aligned region.

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