DRSC/TRiP Functional Genomics Resources

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Protein Alignment ft and PCDHA4

DIOPT Version :10

Sequence 1:NP_477497.1 Gene:ft / 33627 FlyBaseID:FBgn0001075 Length:5147 Species:Drosophila melanogaster
Sequence 2:NP_061730.1 Gene:PCDHA4 / 56144 HGNCID:8670 Length:947 Species:Homo sapiens


Alignment Length:745 Identity:209/745 - (28%)
Similarity:325/745 - (43%) Gaps:132/745 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 RLLLLFFLLLAGRESLCQTGDTKLELLAPRGRSYATTYE-QYAAFPRRRSSSSSPSGEMQSRAVD 66
            |.|||..||||..|:    |:.:|.        |:.:.| ::..|..|               :.
Human    12 RRLLLLLLLLAAWEA----GNGQLH--------YSVSEEAKHGTFVGR---------------IA 49

  Fly    67 TSADFEVLEGQPRGTTVGFIPTKPKFSYRFNEPPR----EFTLDPVTGEVKTNVVLDREGM---- 123
            .....|:.|..||             .:|.....|    |..|.  .|.:..|..:|||.:    
Human    50 QDLGLELAELVPR-------------LFRVASKGRGGLLEVNLQ--NGILFVNSRIDREELCRRS 99

  Fly   124 ---RDHYDLVVLSSQPTYPIEVRIKVLDVNDNSPEFPEPSIAISFSESATSGTRLLLDAATDADV 185
               ..|.:::|  .:|.....|.::|.|:|||.|.||.....:|.:||....:|..|:.|:|||:
Human   100 AECSIHLEVIV--DRPLQVFHVDVEVRDINDNPPVFPATQKNLSIAESRPLDSRFPLEGASDADI 162

  Fly   186 GENGV------TDQY---------EIVAGNVDNKFRLVTTANPSGDTSYLHLETTGNLDRESRGS 235
            |||.:      .::|         |:|.|                    |.|....:||||....
Human   163 GENALLTYRLSPNEYFSLEKPPDDELVKG--------------------LGLILRKSLDREEAPE 207

  Fly   236 YQLNISARDGGSPPRFGYLQVNVTILDVNDNPPIFDHSDYNVSLNETALPGTPVVTVMASDNDLG 300
            ..|.::|.|||.|...|.:|:.:|:||.|||.|.||.:.|.|.|.|....||.|:.:.|||.|.|
Human   208 IFLVLTATDGGKPELTGTVQLLITVLDANDNAPAFDRTIYKVRLLENVPNGTLVIKLNASDLDEG 272

  Fly   301 DNSKITYYLA-----ETEHQFTVNPETGVISTTERVNCPQQTNVKSSASQKSCVFTVFARDHGSP 360
            .|..|.|..:     ..:.:|.::|.||.|.....::..:         .||....|...|.|..
Human   273 LNGDIVYSFSNDISPNVKSKFHIDPITGQIIVKGYIDFEE---------SKSYEIIVEGIDKGQL 328

  Fly   361 RQDGRTYVTVNLLDTNDHDPIISFRFFPDGGKVATVDENAVNGTVVAAVAVKDSDSGLNGRTSVR 425
            ...|...|.|.:.|.||:.|.:.|:...     ..:.|:|..|||:|.::|.|.|.|:||..:..
Human   329 PLSGHCRVIVEVEDNNDNVPDLEFKSLS-----LPIREDAPLGTVIALISVSDKDMGVNGLVTCS 388

  Fly   426 IVSGNELGH--FRLEEA-ADLHIVRVNGVLDREEIGKYNLTVVAMDQGTPARTTTAHLIIDVNDV 487
            :.|     |  |:|... .:.:.:.::..||||.:..|.|.|.|.|.|:|:...||.:.::|.||
Human   389 LTS-----HVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVEVADV 448

  Fly   488 NDHEPVFEKSEYSAVLSELAPTGSFVASITATDEDTGVNAQVHYDILS---GNEL--KWFSMDPL 547
            ||:.|.|.:.||:..:.|..|.|..:.:::|.|.|...||.|.|.::.   |...  .:.|:...
Human   449 NDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRVGERALSSYVSVHAE 513

  Fly   548 TGLIVTTGPLDREIRDTVELSISARDGGPNPKFAYTQLKVIILDENDEAPQFSQREQNVTLG--E 610
            :|.:....|||.|..:.::..::|||.|..|..:...|:|.:|||||.||.........|.|  .
Human   514 SGKVYALQPLDHEELELLQFQVTARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRAGGTGGAVS 578

  Fly   611 DAPPQT-----IVALMTATDHDQGTNGSVTFALAPSVERLYPLQFALDALTGQLTTRRPLDREKM 670
            :..|.:     :||.:.|.|.|.|.|..:::.|.|..... .:.|.:...||:::|.|.||....
Human   579 ELVPWSVGVGHVVAKVRAVDADSGYNAWLSYELQPGTGGA-RIPFRVGLYTGEISTTRALDETDA 642

  Fly   671 SQYEISVIARDQGAPTPQSATATVWLNVAD 700
            .::.:.|:.:|.|.|. .:|||||.:::.:
Human   643 PRHRLLVLVKDHGEPA-LTATATVLVSLVE 671

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ftNP_477497.1 Cadherin_repeat 71..152 CDD:206637 20/91 (22%)
Cadherin_repeat 163..266 CDD:206637 34/117 (29%)
Cadherin_repeat 275..378 CDD:206637 30/107 (28%)
Cadherin_repeat 393..490 CDD:206637 33/99 (33%)
Cadherin_repeat 498..594 CDD:206637 29/100 (29%)
Cadherin_repeat 603..704 CDD:206637 28/105 (27%)
Cadherin_repeat 735..814 CDD:206637
Cadherin 843..>907 CDD:394985
Cadherin 950..1026 CDD:394985
Cadherin_repeat 1053..1149 CDD:206637
Cadherin_repeat 1157..1274 CDD:206637
Cadherin_repeat 1282..1380 CDD:206637
Cadherin_repeat 1390..1485 CDD:206637
Cadherin_repeat 1497..1597 CDD:206637
Cadherin_repeat 1621..1699 CDD:206637
Cadherin_repeat 1720..1818 CDD:206637
Cadherin_repeat 1827..1918 CDD:206637
Cadherin_repeat 1926..2023 CDD:206637
Cadherin_repeat 2031..2162 CDD:206637
Cadherin_repeat 2172..2274 CDD:206637
Cadherin_repeat 2282..2380 CDD:206637
Cadherin_repeat 2388..2487 CDD:206637
Cadherin_repeat 2495..2592 CDD:206637
Cadherin_repeat 2600..2694 CDD:206637
Cadherin_repeat 2710..2806 CDD:206637
Cadherin_repeat 2814..2909 CDD:206637
Cadherin_repeat 2917..3009 CDD:206637
Cadherin 3018..3114 CDD:394985
Cadherin 3129..3220 CDD:394985
Cadherin_repeat 3233..3330 CDD:206637
Cadherin_repeat 3338..3434 CDD:206637
Cadherin_repeat 3443..3541 CDD:206637
Cadherin_repeat 3550..3647 CDD:206637
Cadherin_repeat 3657..3753 CDD:206637
EGF 4017..4047 CDD:394967
EGF_CA 4056..4090 CDD:238011
EGF_CA 4094..4128 CDD:238011
Laminin_G_1 4156..4306 CDD:395008
LamG 4428..4543 CDD:238058
PCDHA4NP_061730.1 Cadherin_2 30..111 CDD:462413 20/120 (17%)
Cadherin_repeat 139..238 CDD:206637 34/118 (29%)
Cadherin_repeat 246..346 CDD:206637 30/108 (28%)
Cadherin_repeat 354..451 CDD:206637 33/106 (31%)
Cadherin_repeat 459..561 CDD:206637 30/101 (30%)
Cadherin_repeat 581..670 CDD:206637 26/90 (29%)
6 X 4 AA repeats of P-X-X-P 734..891
Required for interaction with FYN. /evidence=ECO:0000250|UniProtKB:O88689 738..947
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 754..805
Cadherin_tail 797..913 CDD:435046
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 828..853
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 868..947
Blue background indicates that the domain is not in the aligned region.

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