Protein Alignment ft and PCDHA5

DIOPT Version :10

• Sequence 1: NP_477497.1
• Gene: ft / 33627
• FlyBaseID: FBgn0001075
• Length: 5147
• Species: Drosophila melanogaster
• Sequence 2: NP_061731.1
• Gene: PCDHA5 / 56143
• HGNCID: 8671
• Length: 936
• Species: Homo sapiens
• Alignment Length: 622
• Identity: 191/622 - (30%)
• Similarity: 301/622 - (48%)
• Gaps: 63/622 - (10%)

  Fly   110 GEVKTNVVLDREGM-------RDHYDLVVLSSQPTYPIEVRIKVLDVNDNSPEFPEPSIAISFSE 167
            |.:..|..:|||.:       ..|.:::|  .:|.....|.:.|.|:|||.|.|......:...|
Human    81 GILFVNSRIDREELCRRRAECSIHLEVIV--DRPLQVFHVEVAVKDINDNPPRFSRQEQRLFILE 143

  Fly   168 SATSGTRLLLDAATDADVGENGVTDQYEIVAGNVDNKFRLVTTANPSGDTSYLHLETTGNLDRES 232
            |....:|..|:.|:|.|:|.|... :|.:   |.:..|.|....|.. :|::|.|....:||||.
Human   144 SRMPDSRFPLEGASDLDIGANAQL-RYRL---NPNEYFDLDVKTNEE-ETNFLELVLRKSLDREE 203

  Fly   233 RGSYQLNISARDGGSPPRFGYLQVNVTILDVNDNPPIFDHSDYNVSLNETALPGTPVVTVMASDN 297
            ...::|.:.|.|||.|...|.:|:.:.:||.|||.|.||.|.|||.|.|.|..||.|:.:.|||.
Human   204 TQEHRLLVIATDGGKPELTGTVQLLINVLDANDNAPEFDKSIYNVRLLENAPSGTLVIKLNASDA 268

  Fly   298 DLGDNSKITYY-----LAETEHQFTVNPETGVISTTERVNCPQQTNVKSSASQKSCVFTVFARDH 357
            |.|.|.:|.|:     |.:.:.:|.:|..||.|.....::.....:.:         ..:.|.|.
Human   269 DEGINKEIVYFFSNLVLDDVKSKFIINSNTGEIKVNGELDYEDYNSYE---------INIDAMDK 324

  Fly   358 GSPRQDGRTYVTVNLLDTNDHDP--IISFRFFPDGGKVATVDENAVNGTVVAAVAVKDSDSGLNG 420
            .:....|...|.|.|||.||:.|  .|:..|.|       |.|:|...||:|.::|.|.|||.||
Human   325 STFPLSGHCKVVVKLLDVNDNTPEMAITTLFLP-------VKEDAPLSTVIALISVSDRDSGANG 382

  Fly   421 RTSVRIVSGNELGH--FRLEEA-ADLHIVRVNGVLDREEIGKYNLTVVAMDQGTPARTTTAHLII 482
            :.:..:     :.|  |:|... .:.:.:.::..||||.:..|.|.|.|.|.|:|:...||.:.:
Human   383 QVTCSL-----MPHVPFKLVSTFKNYYSLVLDSALDRESVSVYELVVTARDGGSPSLWATASVSV 442

  Fly   483 DVNDVNDHEPVFEKSEYSAVLSELAPTGSFVASITATDEDTGVNAQVHYDILS---GNE--LKWF 542
            :|.||||:.|.|.:.:|:..:.|..|.|..:.:::|.|.|...||.|.|.::.   |..  ..:.
Human   443 EVADVNDNAPAFAQPQYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERPLSSYV 507

  Fly   543 SMDPLTGLIVTTGPLDREIRDTVELSISARDGGPNPKFAYTQLKVIILDENDEAPQFSQREQNVT 607
            |:...:|.:....|||.|..:.::..:||||.|..|..:...|:|.:|||||.||.........|
Human   508 SVHAESGKVYALQPLDHEEVELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLVPRVGGT 572

  Fly   608 LG--EDAPPQT-----IVALMTATDHDQGTNGSVTFAL--APSVERLYPLQFALDALTGQLTTRR 663
            .|  .:..|::     :||.:.|.|.|.|.|..:::.|  ||...|   :.|.:...||:::|.|
Human   573 GGAVSELVPRSVGAGHVVAKVRAVDPDSGYNAWLSYELQPAPGSAR---IPFRVGLYTGEISTTR 634

  Fly   664 PLDREKMSQYEISVIARDQGAPTPQSATATVWLNVAD 700
            .||..:..::.:.|:.:|.|.| |.:|||||.:::.:
Human   635 SLDETEAPRHRLLVLVKDHGEP-PLTATATVLVSLVE 670

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ft	NP_477497.1	Cadherin_repeat	71..152	CDD:206637	12/48 (25%)
		Cadherin_repeat	163..266	CDD:206637	32/102 (31%)
		Cadherin_repeat	275..378	CDD:206637	32/107 (30%)
		Cadherin_repeat	393..490	CDD:206637	33/99 (33%)
		Cadherin_repeat	498..594	CDD:206637	29/100 (29%)
		Cadherin_repeat	603..704	CDD:206637	31/107 (29%)
		Cadherin_repeat	735..814	CDD:206637
		Cadherin	843..>907	CDD:394985
		Cadherin	950..1026	CDD:394985
		Cadherin_repeat	1053..1149	CDD:206637
		Cadherin_repeat	1157..1274	CDD:206637
		Cadherin_repeat	1282..1380	CDD:206637
		Cadherin_repeat	1390..1485	CDD:206637
		Cadherin_repeat	1497..1597	CDD:206637
		Cadherin_repeat	1621..1699	CDD:206637
		Cadherin_repeat	1720..1818	CDD:206637
		Cadherin_repeat	1827..1918	CDD:206637
		Cadherin_repeat	1926..2023	CDD:206637
		Cadherin_repeat	2031..2162	CDD:206637
		Cadherin_repeat	2172..2274	CDD:206637
		Cadherin_repeat	2282..2380	CDD:206637
		Cadherin_repeat	2388..2487	CDD:206637
		Cadherin_repeat	2495..2592	CDD:206637
		Cadherin_repeat	2600..2694	CDD:206637
		Cadherin_repeat	2710..2806	CDD:206637
		Cadherin_repeat	2814..2909	CDD:206637
		Cadherin_repeat	2917..3009	CDD:206637
		Cadherin	3018..3114	CDD:394985
		Cadherin	3129..3220	CDD:394985
		Cadherin_repeat	3233..3330	CDD:206637
		Cadherin_repeat	3338..3434	CDD:206637
		Cadherin_repeat	3443..3541	CDD:206637
		Cadherin_repeat	3550..3647	CDD:206637
		Cadherin_repeat	3657..3753	CDD:206637
		EGF	4017..4047	CDD:394967
		EGF_CA	4056..4090	CDD:238011
		EGF_CA	4094..4128	CDD:238011
		Laminin_G_1	4156..4306	CDD:395008
		LamG	4428..4543	CDD:238058
PCDHA5	NP_061731.1	Cadherin_2	29..110	CDD:462413	7/30 (23%)
		Cadherin_repeat	136..237	CDD:206637	32/105 (30%)
		Cadherin_repeat	245..345	CDD:206637	32/108 (30%)
		Cadherin_repeat	358..450	CDD:206637	33/96 (34%)
		Cadherin_repeat	458..560	CDD:206637	30/101 (30%)
		Cadherin_repeat	580..669	CDD:206637	29/92 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	759..793
		5 X 4 AA repeats of P-X-X-P	773..890
		Cadherin_tail	786..902	CDD:435046
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	816..936