DRSC/TRiP Functional Genomics Resources

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Protein Alignment ft and PCDHA8

DIOPT Version :10

Sequence 1:NP_477497.1 Gene:ft / 33627 FlyBaseID:FBgn0001075 Length:5147 Species:Drosophila melanogaster
Sequence 2:NP_061734.1 Gene:PCDHA8 / 56140 HGNCID:8674 Length:950 Species:Homo sapiens


Alignment Length:739 Identity:213/739 - (28%)
Similarity:336/739 - (45%) Gaps:121/739 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 RLLLLFFLLLAGRESLCQTGDTKLELLAPRGRSYATTYEQYAAFPRRRSSSSSPSGEMQSRAVDT 67
            |||||..||.|.:..                                       ||::.      
Human    13 RLLLLLLLLAAWKVG---------------------------------------SGQLH------ 32

  Fly    68 SADFEVLEGQPRGTTVG------------FIPTKPKFSYRFNEPPREFTLDPVTGEVKTNVVLDR 120
               :.|.|....||.||            .:|...:.:.:.:....|.:|.  .|.:..|..:||
Human    33 ---YSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRVASKRHRDLLEVSLQ--NGILFVNSRIDR 92

  Fly   121 EGM-------RDHYDLVVLSSQPTYPIEVRIKVLDVNDNSPEFPEPSIAISFSESATSGTRLLLD 178
            |.:       ..|.:::|  .:|.....|.::|.|||||.|.|......:..|||....:|..|:
Human    93 EELCGRSAECSIHLEVIV--DRPLQVFHVDVEVKDVNDNPPVFRVKDQKLFVSESRMPDSRFPLE 155

  Fly   179 AATDADVGENGVTDQYEIVAGNVDNKFRLVTTANPSGDTSYLHLETTGNLDRESRGSYQLNISAR 243
            .|:|||||.|.|. .|.:.:    :.:.::...:.:.:...:.|....:||||...::.|.::|.
Human   156 GASDADVGANSVL-TYRLSS----HDYFMLDVNSKNDENKLVELVLRKSLDREDAPAHHLFLTAT 215

  Fly   244 DGGSPPRFGYLQVNVTILDVNDNPPIFDHSDYNVSLNETALPGTPVVTVMASDNDLGDNSKITY- 307
            |||.|...|.:|:.||:||||||.|.|:.|:|.|.:.|.|..||.|:.:.|||.|.|.|..|:| 
Human   216 DGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYEVRIFENADNGTTVIKLNASDPDEGANGAISYS 280

  Fly   308 --YLAET---EHQFTVNPETGVISTTERVNCPQQTNVKSSASQKSCVFTVFARDHGSPRQDGRTY 367
              .|.||   :| |:::..||.|.....::..|:...|         ..:.|.|.|.|...|...
Human   281 FNSLVETMVIDH-FSIDRNTGEIVIRGNLDFEQENLYK---------ILIDATDKGHPPMAGHCT 335

  Fly   368 VTVNLLDTNDHDPIISFRFFPDGGKVATVDENAVNGTVVAAVAVKDSDSGLNGRTSVRIVSGNEL 432
            |.|.:||.||:.|.|:.....     ..|.|:|..|||:|.::|.|.|||.||:.:..:     :
Human   336 VLVRILDKNDNVPEIALTSLS-----LPVREDAQFGTVIALISVNDLDSGANGQVTCSL-----M 390

  Fly   433 GH--FRLEEA-ADLHIVRVNGVLDREEIGKYNLTVVAMDQGTPARTTTAHLIIDVNDVNDHEPVF 494
            .|  |:|... .:.:.:.::..||||.:..|.|.|.|.|.|:|:...||.|.::|.||||:.|.|
Human   391 PHVPFKLVSTFKNYYSLVLDSALDRERVSAYELVVTARDGGSPSLWATASLSVEVADVNDNAPAF 455

  Fly   495 EKSEYSAVLSELAPTGSFVASITATDEDTGVNAQVHYDILS---GNE--LKWFSMDPLTGLIVTT 554
            .:.||:..:.|..|.|..:.:::|.|.|...||.|.|.::.   |..  ..:.|:...:|.:...
Human   456 AQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERSLSSYISVHTESGKVYAL 520

  Fly   555 GPLDREIRDTVELSISARDGGPNPKFAYTQLKVIILDENDEAPQFSQREQNVTLGEDAP--PQT- 616
            .|||.|..:.::..:||||.|..|..:...|:|.:|||||.||...:.....|.|..:.  |:: 
Human   521 QPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLEPRVGGTGGAASKLVPRSV 585

  Fly   617 ----IVALMTATDHDQGTNGSVTFALAPSVERLYP-LQFALDALTGQLTTRRPLDREKMSQYEIS 676
                :||.:.|.|.|.|.|..:::.|.|:...  | :.|.:...||:::|.|.||.....::.:.
Human   586 GAGHVVAKVRAVDADSGYNAWLSYELQPAASS--PRIPFRVGLYTGEISTTRVLDEADSPRHRLL 648

  Fly   677 VIARDQGAPTPQSATATVWLNVAD 700
            |:.:|.|.|. .:|||||.:::.:
Human   649 VLVKDHGEPA-LTATATVLVSLVE 671

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ftNP_477497.1 Cadherin_repeat 71..152 CDD:206637 22/99 (22%)
Cadherin_repeat 163..266 CDD:206637 33/102 (32%)
Cadherin_repeat 275..378 CDD:206637 35/108 (32%)
Cadherin_repeat 393..490 CDD:206637 35/99 (35%)
Cadherin_repeat 498..594 CDD:206637 30/100 (30%)
Cadherin_repeat 603..704 CDD:206637 29/106 (27%)
Cadherin_repeat 735..814 CDD:206637
Cadherin 843..>907 CDD:394985
Cadherin 950..1026 CDD:394985
Cadherin_repeat 1053..1149 CDD:206637
Cadherin_repeat 1157..1274 CDD:206637
Cadherin_repeat 1282..1380 CDD:206637
Cadherin_repeat 1390..1485 CDD:206637
Cadherin_repeat 1497..1597 CDD:206637
Cadherin_repeat 1621..1699 CDD:206637
Cadherin_repeat 1720..1818 CDD:206637
Cadherin_repeat 1827..1918 CDD:206637
Cadherin_repeat 1926..2023 CDD:206637
Cadherin_repeat 2031..2162 CDD:206637
Cadherin_repeat 2172..2274 CDD:206637
Cadherin_repeat 2282..2380 CDD:206637
Cadherin_repeat 2388..2487 CDD:206637
Cadherin_repeat 2495..2592 CDD:206637
Cadherin_repeat 2600..2694 CDD:206637
Cadherin_repeat 2710..2806 CDD:206637
Cadherin_repeat 2814..2909 CDD:206637
Cadherin_repeat 2917..3009 CDD:206637
Cadherin 3018..3114 CDD:394985
Cadherin 3129..3220 CDD:394985
Cadherin_repeat 3233..3330 CDD:206637
Cadherin_repeat 3338..3434 CDD:206637
Cadherin_repeat 3443..3541 CDD:206637
Cadherin_repeat 3550..3647 CDD:206637
Cadherin_repeat 3657..3753 CDD:206637
EGF 4017..4047 CDD:394967
EGF_CA 4056..4090 CDD:238011
EGF_CA 4094..4128 CDD:238011
Laminin_G_1 4156..4306 CDD:395008
LamG 4428..4543 CDD:238058
PCDHA8NP_061734.1 Cadherin_2 30..111 CDD:462413 16/93 (17%)
Cadherin_repeat 140..238 CDD:206637 33/102 (32%)
Cadherin_repeat 246..346 CDD:206637 35/109 (32%)
Cadherin_repeat 354..451 CDD:206637 35/106 (33%)
Cadherin_repeat 459..561 CDD:206637 31/101 (31%)
Cadherin_repeat 581..670 CDD:206637 27/91 (30%)
5 X 4 AA repeats of P-X-X-P 774..894
Cadherin_tail 800..916 CDD:435046
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 830..950
Blue background indicates that the domain is not in the aligned region.

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