Protein Alignment ft and PCDHA10

DIOPT Version :10

• Sequence 1: NP_477497.1
• Gene: ft / 33627
• FlyBaseID: FBgn0001075
• Length: 5147
• Species: Drosophila melanogaster
• Sequence 2: NP_061724.1
• Gene: PCDHA10 / 56139
• HGNCID: 8664
• Length: 948
• Species: Homo sapiens
• Alignment Length: 627
• Identity: 187/627 - (29%)
• Similarity: 295/627 - (47%)
• Gaps: 73/627 - (11%)

  Fly   110 GEVKTNVVLDREGM-------RDHYDLVVLSSQPTYPIEVRIKVLDVNDNSPEFPEPSIAISFSE 167
            |.:..|..:|||.:       ..|.:::|  .:|.....|.::|.|:|||.|.|......:|..|
Human    81 GILFVNSRIDREELCGRSVECSIHLEVIV--DRPLQVFHVDVEVKDINDNPPRFSVTEQKLSIPE 143

  Fly   168 SATSGTRLLLDAATDADVGENGVTDQYEIVAGNVDNKFRLVTTANPSGDTSYLHLETTGNLDRES 232
            |....:|..|:.|:|||||||.:. .|::    ..|::.::...|......:..|.....||||.
Human   144 SRLLDSRFPLEGASDADVGENALL-TYKL----SPNEYFVLDIINKKDKDKFPVLVLRKLLDREE 203

  Fly   233 RGSYQLNISARDGGSPPRFGYLQVNVTILDVNDNPPIFDHSDYNVSLNETALPGTPVVTVMASDN 297
            ....:|.::|.|||.|...|.:.:.:.:||.|||.||||...|.|.:.|..:..|.|:.:.|||:
Human   204 NPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPIFDRPVYEVKMYENQVNQTLVIRLNASDS 268

  Fly   298 DLGDNSKITYYLAE-----TEHQFTVNPETGVISTTERVNCPQQTNVKSSASQKSCVFTVFARDH 357
            |.|.|.::.|..:.     ...:|.:|..||.|...:.::.......:         ..|...|.
Human   269 DEGINKEMMYSFSSLVPPTIRRKFWINERTGEIKVNDAIDFEDSNTYE---------IHVDVTDK 324

  Fly   358 GSPRQDGRTYVTVNLLDTNDHDP--IISFRFFPDGGKVATVDENAVNGTVVAAVAVKDSDSGLNG 420
            |:|...|...|.|.|||.||:.|  |::....|       |.|:|..|||:|.::|.|.|||.||
Human   325 GNPPMVGHCTVLVELLDENDNSPEVIVTSLSLP-------VKEDAQVGTVIALISVSDHDSGANG 382

  Fly   421 RTSVRIVSGNELGH--FRLEEA-ADLHIVRVNGVLDREEIGKYNLTVVAMDQGTPARTTTAHLII 482
            :.:..:..     |  |:|... .:.:.:.::..||||.:..|.|.|.|.|.|:|....||.:.:
Human   383 QVTCSLTP-----HVPFKLVSTYKNYYSLVLDSALDRERVSAYELVVTARDGGSPPLWATASVSV 442

  Fly   483 DVNDVNDHEPVFEKSEYSAVLSELAPTGSFVASITATDEDTGVNAQVHYDI----LSGNEL-KWF 542
            :|.||||:.|.|.:|||:..:.|..|.|..:.:::|.|.|...||.|.|.:    |....| .:.
Human   443 EVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRLGERSLSSYV 507

  Fly   543 SMDPLTGLIVTTGPLDREIRDTVELSISARDGGPNPKFAYTQLKVIILDENDEAPQFSQRE---- 603
            |:...:|.:....|||.|..:.::..:||||||..|..:...|:|.:|||||.||......
Human   508 SVHAESGKVYALQPLDHEELELLQFQVSARDGGVPPLGSNLTLQVFVLDENDNAPALLASPAGSA 572

  Fly   604 ---------QNVTLGEDAPPQTIVALMTATDHDQGTNGSVTFAL-APSVERLYPLQFALDALTGQ 658
                     ::|..|.      :||.:.|.|.|.|.|..:::.| :.:|....|  |.:...||:
Human   573 GGAVSELVLRSVVAGH------VVAKVRAVDADSGYNAWLSYELQSAAVGARIP--FRVGLYTGE 629

  Fly   659 LTTRRPLDREKMSQYEISVIARDQGAPTPQSATATVWLNVAD 700
            ::|.|.||.....:..:.|:.:|.|.|: .:|||||.:::.:
Human   630 ISTTRALDETDSPRQRLLVLVKDHGEPS-LTATATVLVSLVE 670

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ft	NP_477497.1	Cadherin_repeat	71..152	CDD:206637	12/48 (25%)
		Cadherin_repeat	163..266	CDD:206637	31/102 (30%)
		Cadherin_repeat	275..378	CDD:206637	28/107 (26%)
		Cadherin_repeat	393..490	CDD:206637	34/99 (34%)
		Cadherin_repeat	498..594	CDD:206637	32/100 (32%)
		Cadherin_repeat	603..704	CDD:206637	28/112 (25%)
		Cadherin_repeat	735..814	CDD:206637
		Cadherin	843..>907	CDD:394985
		Cadherin	950..1026	CDD:394985
		Cadherin_repeat	1053..1149	CDD:206637
		Cadherin_repeat	1157..1274	CDD:206637
		Cadherin_repeat	1282..1380	CDD:206637
		Cadherin_repeat	1390..1485	CDD:206637
		Cadherin_repeat	1497..1597	CDD:206637
		Cadherin_repeat	1621..1699	CDD:206637
		Cadherin_repeat	1720..1818	CDD:206637
		Cadherin_repeat	1827..1918	CDD:206637
		Cadherin_repeat	1926..2023	CDD:206637
		Cadherin_repeat	2031..2162	CDD:206637
		Cadherin_repeat	2172..2274	CDD:206637
		Cadherin_repeat	2282..2380	CDD:206637
		Cadherin_repeat	2388..2487	CDD:206637
		Cadherin_repeat	2495..2592	CDD:206637
		Cadherin_repeat	2600..2694	CDD:206637
		Cadherin_repeat	2710..2806	CDD:206637
		Cadherin_repeat	2814..2909	CDD:206637
		Cadherin_repeat	2917..3009	CDD:206637
		Cadherin	3018..3114	CDD:394985
		Cadherin	3129..3220	CDD:394985
		Cadherin_repeat	3233..3330	CDD:206637
		Cadherin_repeat	3338..3434	CDD:206637
		Cadherin_repeat	3443..3541	CDD:206637
		Cadherin_repeat	3550..3647	CDD:206637
		Cadherin_repeat	3657..3753	CDD:206637
		EGF	4017..4047	CDD:394967
		EGF_CA	4056..4090	CDD:238011
		EGF_CA	4094..4128	CDD:238011
		Laminin_G_1	4156..4306	CDD:395008
		LamG	4428..4543	CDD:238058
PCDHA10	NP_061724.1	Cadherin_2	29..110	CDD:462413	7/30 (23%)
		Cadherin_repeat	136..237	CDD:206637	31/105 (30%)
		Cadherin_repeat	245..345	CDD:206637	28/108 (26%)
		Cadherin_repeat	353..450	CDD:206637	35/108 (32%)
		Cadherin_repeat	458..560	CDD:206637	33/101 (33%)
		Cadherin_repeat	580..669	CDD:206637	28/97 (29%)
		6 X 4 AA repeats of P-X-X-P	732..892
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	783..804
		Cadherin_tail	798..914	CDD:435046
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	827..948