Protein Alignment ft and PCDHA12

DIOPT Version :10

• Sequence 1: NP_477497.1
• Gene: ft / 33627
• FlyBaseID: FBgn0001075
• Length: 5147
• Species: Drosophila melanogaster
• Sequence 2: NP_061726.1
• Gene: PCDHA12 / 56137
• HGNCID: 8666
• Length: 941
• Species: Homo sapiens
• Alignment Length: 937
• Identity: 241/937 - (25%)
• Similarity: 391/937 - (41%)
• Gaps: 194/937 - (20%)

  Fly   928 VNIAIIDLNDNAPVFALDRESEPTISLPENAAVGQEIYLSRVRDRDAGVNSRISYSLTNNPNQQF 992
            |::.:.|:|||.|||   ||.|..:.:.|:|.:.....|....|.|.||||.::|:|:.|.|.:.
Human   119 VDVEVKDINDNPPVF---REREQKVPVSESAPLDSHFPLEGASDADIGVNSLLTYALSLNENFEL 180

  Fly   993 RI-----GPVTGVLYLQRPIRAEPGSLIHVELMATDAGSPPLSSKLSLSVLIADVNDHTPVFDHT 1052
            :|     ..:...|.|::.:..|....:::.||..|.|.|.|:..:.:.:.:.||||:.|.||..
Human   181 KIKTKKDKSILPELVLRKLLDREQTPKLNLLLMVIDGGKPELTGSVQIQITVLDVNDNGPAFDKP 245

  Fly  1053 SYETSLPETTKVNTRFFALAATDIDLGDNGRISY---EIIEGNTERMFGVFPD-GYLFVRAPLDR 1113
            ||:..|.|..:.:||...|.|:|.|.|.||.|||   .|:..:.:.||.:.|| |.:.:...||.
Human   246 SYKVVLSENVQNDTRVIQLNASDPDEGLNGEISYGIKMILPVSEKCMFSINPDTGEIRIYGELDF 310

  Fly  1114 EERDYYALTVSCRDAGQPSRSSVVPVVIHVIDENDNAPQFTNSTFTFSIPENAPADTFVGKLTAV 1178
            ||.:.|.:.|:..|.|.||.:....|::.|:|.|||.|:...::.:..:.|:|...|.:..::..
Human   311 EENNAYEIQVNAIDKGIPSMAGHSMVLVEVLDVNDNVPEVMVTSLSLPVQEDAQVGTVIALISVS 375

  Fly  1179 DRDIGRNAELSFTLSSQTQDFTIDTRNGFIKTLRPFDREALVKVSRNAEASGEDGSLRGSMAGNY 1243
            |||.|.|.::..:|:...                ||   .||...:|..:...|.:|.......|
Human   376 DRDSGANGQVICSLTPHV----------------PF---KLVSTYKNYYSLVLDSALDRESVSAY 421

  Fly  1244 MLLEATVSDNGIPRLQDKVKVKVIVTDVNDNAPEFLRAPYHVTISEGASEGTHITHVFTQDADEG 1308
            .|: .|..|.|.|.|....:|.|.|.|||||||.|.:..|.|.:.|....|.||..|...|||..
Human   422 ELV-VTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQ 485

  Fly  1309 LNGDVYYSLAKGNEAGQFNLDS------ATGQLSLGRRLDRESQEIHHLIVVAKDAALKHPLSSN 1367
            .|..|.|||.: ...|:..|.|      .:|::...:.||.|..|:....|.|:||.:. ||.||
Human   486 KNALVSYSLVE-RRVGEHALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVP-PLGSN 548

  Fly  1368 ASITIVVLDENDNAPEFTQS---SSEVSVLETSP----TGTELMRFRASDADQGVNSQVVFSI-- 1423
            .::.:.|||||||||....:   |:..:|.|..|    .|..:.:.||.|||.|.|:.:.:.:
Human   549 VTLQVFVLDENDNAPALLATPAGSAGGAVSELVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQP 613

  Fly  1424 SAGNRRDTFHIDSITGSLYLHKPLDYEDITSYTLNITASDCGTPSLSTTVLYNVLVVDDNDNPPI 1488
            :|......||:...||.:...:.||..|...:.|.:...|.|.|:|::|
Human   614 AAVGAHIPFHVGLYTGEISTTRILDEADAPRHRLLVLVKDHGEPALTST---------------- 662

  Fly  1489 FPSTAIVRQIKEG-IPLKTPIVTVTADDPDSGLNGKVSYAISKQEPQLPQGRHFGINTETGVIHT 1552
              :|.:|..::.| .|..:...:|.|.||::.|
Human   663 --ATVLVSLVENGQAPKTSSRASVGAVDPEAAL-------------------------------- 693

  Fly  1553 LREIDRESIDTFRLTVVATDRAQPSERQLSTEKLVTVIV-EDINDNAPVFVSMNAAILPPKFSTS 1616
               :|   |:.:.:..:..         :|:..::|::: ..:..:||..||..|...|....:|
Human   694 ---VD---INVYLIIAICA---------VSSLLVLTLLLYTALRCSAPPTVSRCAPGKPTLVCSS 743

  Fly  1617 KGSSTAVMQVHAKDADSSSNGLVTYEIVSGPQELFKLQRNTGIITFTPGPQFKQE---------- 1671
            ...|.:..|...:...|:.         |.|:        |.::.|:|..|..:|
Human   744 AVGSWSYSQQRRQRVCSAE---------SPPK--------TDLMAFSPSLQLSREDCLNPPSEPR 791

  Fly  1672 -----VRYQLTLKSTDEAVQSERRSSEVYIT---IITPGSGGSE-------SSVPQFEQRSKLSG 1721
                 .||..:|::        ...|.|::.   |:..|.||.:       |:.|:.|     :|
Human   792 QPNPDWRYSASLRA--------GMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPE-----AG 843

  Fly  1722 SVYENEPIGTSILTVTAHLASAEIEYFVTNVTATGSRGQVDRLFDIDAKLGILS-----TAAELD 1781
            .|  :.|:|..:     :..|...:|...|...:|. |::...|.|.....|:|     |.:::|
Human   844 EV--SPPVGAGV-----NSNSWTFKYGPGNPKQSGP-GELPDKFIIPGSPAIISIRQEPTNSQID 900

  Fly  1782 REAGPEEYEVEVYAIALGGQPRTSRTK 1808
            :..          .|..|.:..|.:.|
Human   901 KSD----------FITFGKKEETKKKK 917

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ft	NP_477497.1	Cadherin_repeat	71..152	CDD:206637
		Cadherin_repeat	163..266	CDD:206637
		Cadherin_repeat	275..378	CDD:206637
		Cadherin_repeat	393..490	CDD:206637
		Cadherin_repeat	498..594	CDD:206637
		Cadherin_repeat	603..704	CDD:206637
		Cadherin_repeat	735..814	CDD:206637
		Cadherin	843..>907	CDD:394985
		Cadherin	950..1026	CDD:394985	20/80 (25%)
		Cadherin_repeat	1053..1149	CDD:206637	36/99 (36%)
		Cadherin_repeat	1157..1274	CDD:206637	29/116 (25%)
		Cadherin_repeat	1282..1380	CDD:206637	36/103 (35%)
		Cadherin_repeat	1390..1485	CDD:206637	25/100 (25%)
		Cadherin_repeat	1497..1597	CDD:206637	11/101 (11%)
		Cadherin_repeat	1621..1699	CDD:206637	14/95 (15%)
		Cadherin_repeat	1720..1818	CDD:206637	19/94 (20%)
		Cadherin_repeat	1827..1918	CDD:206637
		Cadherin_repeat	1926..2023	CDD:206637
		Cadherin_repeat	2031..2162	CDD:206637
		Cadherin_repeat	2172..2274	CDD:206637
		Cadherin_repeat	2282..2380	CDD:206637
		Cadherin_repeat	2388..2487	CDD:206637
		Cadherin_repeat	2495..2592	CDD:206637
		Cadherin_repeat	2600..2694	CDD:206637
		Cadherin_repeat	2710..2806	CDD:206637
		Cadherin_repeat	2814..2909	CDD:206637
		Cadherin_repeat	2917..3009	CDD:206637
		Cadherin	3018..3114	CDD:394985
		Cadherin	3129..3220	CDD:394985
		Cadherin_repeat	3233..3330	CDD:206637
		Cadherin_repeat	3338..3434	CDD:206637
		Cadherin_repeat	3443..3541	CDD:206637
		Cadherin_repeat	3550..3647	CDD:206637
		Cadherin_repeat	3657..3753	CDD:206637
		EGF	4017..4047	CDD:394967
		EGF_CA	4056..4090	CDD:238011
		EGF_CA	4094..4128	CDD:238011
		Laminin_G_1	4156..4306	CDD:395008
		LamG	4428..4543	CDD:238058
PCDHA12	NP_061726.1	Cadherin_2	30..111	CDD:462413
		Cadherin_repeat	137..238	CDD:206637	27/100 (27%)
		Cadherin_repeat	246..346	CDD:206637	36/99 (36%)
		Cadherin_repeat	354..451	CDD:206637	29/116 (25%)
		Cadherin_repeat	459..561	CDD:206637	36/103 (35%)
		Cadherin_repeat	581..670	CDD:206637	25/106 (24%)
		5 X 4 AA repeats of P-X-X-P	734..885		35/188 (19%)
		Cadherin_tail	791..907	CDD:435046	28/146 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	818..941		26/123 (21%)