Protein Alignment ft and PCDH8

DIOPT Version :10

• Sequence 1: NP_477497.1
• Gene: ft / 33627
• FlyBaseID: FBgn0001075
• Length: 5147
• Species: Drosophila melanogaster
• Sequence 2: NP_002581.2
• Gene: PCDH8 / 5100
• HGNCID: 8660
• Length: 1070
• Species: Homo sapiens
• Alignment Length: 710
• Identity: 209/710 - (29%)
• Similarity: 314/710 - (44%)
• Gaps: 107/710 - (15%)

  Fly    61 QSRAVDTSADFEVLEGQPRGTTVGFI----------PTKPKFSYRFNEP---PREFTLDPVTGEV 112
            ||:.|..|. ||  |..| ||.:|.:          .|..:...:||..   .||.......|:.
Human    28 QSKTVRYST-FE--EDAP-GTVIGTLAEDLHMKVSGDTSFRLMKQFNSSLLRVREGDGQLTVGDA 88

  Fly   113 KTNVVLDREGMRDH-------YDLVVLSSQPTYPIEVRIKVLDVNDNSPEFPEPSIAISFSESAT 170
            .    ||||.:...       :|:|..|.:....:.|.::|.||||::|.||...|.:..||.|.
Human    89 G----LDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAPRFPRAQIPVEVSEGAA 149

  Fly   171 SGTRLLLDAATDADVGENGVTDQYEIVAGNVDNKFR--LVTTANPSGDTSYLHLETTGNLDRESR 233
            .|||:.|:...|.|||.||:   ..:......:.||  |.|.|:.:.....:.|:   .|||||:
Human   150 VGTRIPLEVPVDEDVGANGL---QTVRLAEPHSPFRVELQTRADGAQCADLVLLQ---ELDRESQ 208

  Fly   234 GSYQLNISARDGGSPPRFGYLQVNVTILDVNDNPPIFDHSDY-NVSLNETALPGTPVVTVMASDN 297
            .:|.|.:.|:|||.|||.....::|.:||.||:.|.|..... .|.|.|.|..|:.::.:.|:|.
Human   209 AAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVELAEDAPVGSLLLDLDAADP 273

  Fly   298 DLGDNSKITYYLA-----ETEHQFTVNPETGVISTTERVNCPQQTNVKSSASQKSCVFTVFARDH 357
            |.|.|..:.:...     |....|.::|.:|.::....|:..:|...:         ..|.|:|.
Human   274 DEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVDYERQDTYE---------LDVRAQDR 329

  Fly   358 GSPRQDGRTYVTVNLLDTNDHDPIISFRFF---------------------------------PD 389
            |...:.....|.|.:.|.||:.|.|:....                                 |:
Human   330 GPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSPFAAAAAAAALGGADASSPAGAGTPE 394

  Fly   390 GGKVATVDENAVNGTVVAAVAVKDSDSGLNGRTSVRIVSGNELGHFRLEEA-ADLHIVRVNGVLD 453
            .|..:.|.|.|...::||.|:..|.|||.||:....:. |:|  ||||:.| |..::|.....||
Human   395 AGATSLVPEGAARESLVALVSTSDRDSGANGQVRCALY-GHE--HFRLQPAYAGSYLVVTAASLD 456

  Fly   454 REEIGKYNLTVVAMDQGTPARTTTAHLIIDVNDVNDHEPVFEKSEYSAVLSELAPTGSFVASITA 518
            ||.|.:||||:||.|:|.|...|.....:.|.|.||:.|:|.:..|...:.|..|.|:::|::.|
Human   457 RERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAA 521

  Fly   519 TDEDTGVNAQVHYDIL-------SGNELKWFSMDPLTGLIVTTGPLDREIRDTVELSISARDGGP 576
            .|.|.|.|.||.|.:|       .|....:.|:||.||.|......|.|....:::.|.|.|||
Human   522 RDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGG- 585

  Fly   577 NPKFAYTQL-KVIILDENDEAPQF-----SQREQNVTLGEDAPPQTIVALMTATDHDQGTNGSVT 635
            :|:.:.:.| :|.:||:||.||..     :.....|.:.......|:||.:.|.|.|:|.||.:.
Human   586 SPQLSSSALVQVRVLDQNDHAPVLVHPAPANGSLEVAVPGRTAKDTVVARVQARDADEGANGELA 650

  Fly   636 FALAPSVERLYPLQFALDALTGQLTTRRPLDREKMSQ-YEISVIARDQGAPTPQSATATV 694
            |.|.....|   ..||:...||::.....|.:|...: :...::..|.|.| |.:.||||
Human   651 FELQQQEPR---EAFAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRP-PLTTTATV 706

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ft	NP_477497.1	Cadherin_repeat	71..152	CDD:206637	25/100 (25%)
		Cadherin_repeat	163..266	CDD:206637	37/104 (36%)
		Cadherin_repeat	275..378	CDD:206637	24/108 (22%)
		Cadherin_repeat	393..490	CDD:206637	39/97 (40%)
		Cadherin_repeat	498..594	CDD:206637	33/103 (32%)
		Cadherin_repeat	603..704	CDD:206637	27/93 (29%)
		Cadherin_repeat	735..814	CDD:206637
		Cadherin	843..>907	CDD:394985
		Cadherin	950..1026	CDD:394985
		Cadherin_repeat	1053..1149	CDD:206637
		Cadherin_repeat	1157..1274	CDD:206637
		Cadherin_repeat	1282..1380	CDD:206637
		Cadherin_repeat	1390..1485	CDD:206637
		Cadherin_repeat	1497..1597	CDD:206637
		Cadherin_repeat	1621..1699	CDD:206637
		Cadherin_repeat	1720..1818	CDD:206637
		Cadherin_repeat	1827..1918	CDD:206637
		Cadherin_repeat	1926..2023	CDD:206637
		Cadherin_repeat	2031..2162	CDD:206637
		Cadherin_repeat	2172..2274	CDD:206637
		Cadherin_repeat	2282..2380	CDD:206637
		Cadherin_repeat	2388..2487	CDD:206637
		Cadherin_repeat	2495..2592	CDD:206637
		Cadherin_repeat	2600..2694	CDD:206637
		Cadherin_repeat	2710..2806	CDD:206637
		Cadherin_repeat	2814..2909	CDD:206637
		Cadherin_repeat	2917..3009	CDD:206637
		Cadherin	3018..3114	CDD:394985
		Cadherin	3129..3220	CDD:394985
		Cadherin_repeat	3233..3330	CDD:206637
		Cadherin_repeat	3338..3434	CDD:206637
		Cadherin_repeat	3443..3541	CDD:206637
		Cadherin_repeat	3550..3647	CDD:206637
		Cadherin_repeat	3657..3753	CDD:206637
		EGF	4017..4047	CDD:394967
		EGF_CA	4056..4090	CDD:238011
		EGF_CA	4094..4128	CDD:238011
		Laminin_G_1	4156..4306	CDD:395008
		LamG	4428..4543	CDD:238058
PCDH8	NP_002581.2	Cadherin_2	31..109	CDD:462413	20/85 (24%)
		Cadherin_repeat	139..241	CDD:206637	38/107 (36%)
		Cadherin_repeat	252..350	CDD:206637	24/106 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	382..401		2/18 (11%)
		Cadherin_repeat	401..493	CDD:206637	39/94 (41%)
		Cadherin_repeat	501..605	CDD:206637	34/104 (33%)
		Cadherin_repeat	618..711	CDD:206637	27/93 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	715..736
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	779..861
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	907..929
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1045..1070