DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ft and cdhr1a

DIOPT Version :9

Sequence 1:	NP_477497.1	Gene:	ft / 33627	FlyBaseID:	FBgn0001075	Length:	5147	Species:	Drosophila melanogaster
Sequence 2:	NP_001005402.1	Gene:	cdhr1a / 449008	ZFINID:	ZDB-GENE-040924-4	Length:	857	Species:	Danio rerio

Alignment Length:	953	Identity:	227/953 - (23%)
Similarity:	375/953 - (39%)	Gaps:	223/953 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  1816 KNDSPPQFLD--------TPFVYNVSEDLQIGHTISTLRAHDPD---TLGSVTFLLMDGHDGKFL 1869
            ::|..|.|.|        ...:.|:|||...|..|..|...||:   ....:||  ..|....|.
Zfish    24 QSDYAPYFYDNGPNSNNGNMALLNLSEDTPRGTQIYVLNGTDPEGQPVKYGITF--EPGSKEFFR 86

  Fly  1870 LEPSTGKLILNDTLDRETKSKYELRIRVSDGVQYTEAYATIQVSDTNDNPPLFEDTVYSFDIPEN 1934
            :.|.:|.:.|.:.||||.:.:.|:.:.:||.:.......::.:.|.||..|.|::.....|:|||
Zfish    87 VHPKSGVVTLIEDLDREAQDEIEVFVSISDSLNKVVEKVSVFIMDANDERPQFQNMPSIVDVPEN 151

  Fly  1935 AQRGYQVGQIVARDADLGQNAQLSYGVVSDWANDVFSLNPQTGMLTLT--ARLDYEEVQHYILIV 1997
            ...|..:.::.|.|.|.|....::|.:.|...:..|:::..:|:|.:.  ..||||:.:.:.:.|
Zfish   152 TTSGSSIYKVQAVDRDTGSGGSVTYFLQSSEQSPKFAIDHHSGVLRIKPGESLDYEKSRTHFITV 216

  Fly  1998 QAQDNG------QPSLSTTITVYCNVLDLNDNAPIFDPMSYSSEVFENVPIATEVVTVSAKDIDS 2056
            .|:|.|      |..:|::.|:..||:|..|:.|||....|...|:|.....:|:.||||||.|.
Zfish   217 VAKDGGGIYKGKQQVMSSSATLTINVIDTQDSPPIFIGTPYFGYVYEVSSPGSEIFTVSAKDGDM 281

  Fly  2057 GNNGLIEYSITAGDVDSEFGIDSNGTIRTRRNLDRE-HRSTYTLTVTARDCADEFASFSELEETQ 2120
            .|...|.||:.:| .|..|.|:....:.|......: .|..:.:.|.|.:.:.|
Zfish   282 DNPNTIIYSLDSG-ADGSFSINKTSGVITLNLYPADLRREVFNIKVKALEISPE----------- 334

  Fly  2121 LKLKYRSPRKYQQTRQEFLAHQKQQRLSSTVKVTILIKDVNDEVPVFISAN------ETAIMENV 2179
                        ..|.:|          :|..|||.:.|:|:..|.|...|      |..:.|:.
Zfish   335 ------------GKRLDF----------ATTTVTIRVVDLNNHPPTFYGENGPQNVFELTMYEHP 377

  Fly  2180 AINTVVIAVKAV--DNDEGRNGYIDYLMKEARDEDMGQSDPL---PFS-LNPTDGQLRVVD--AL 2236
            .....:..:|..  |:|:|.|...:..:       :|....|   |.: ||.....:.|.|  |:
Zfish   378 QEGEFLRGLKITVNDSDQGSNAKFNLRL-------VGPGRMLRVVPQTVLNEAQVTVLVEDSAAM 435

  Fly  2237 DRELRSSYLLNITARDRGEPPQ-STESQLLIRILDENDNSPVFDPKQYSASVAENASIGAMVLQV 2300
            |.|........:.|.:...|.: |..:.::|.:||.|||:|.|....|.|.:.||:..|:.|:.|
Zfish   436 DFEKSQFLTFKLLAVEIDTPERFSATADIIIHLLDTNDNAPKFTSDFYIARIPENSPGGSNVVSV 500

  Fly  2301 SATDVDEGANGRIRYSIVLGDQNHDFSISEDTGVVRVA--KNLNYERLSRYSLTVRAEDCALENP 2363
            :|.|.|.|..|.::||| .|.....|.|..|:|::...  .:|:.|..|:|:..|:|||     |
Zfish   501 TAMDPDSGIWGVVKYSI-YGSGADIFLIQADSGIIYTQPWASLDAEVKSKYNFYVKAED-----P 559

  Fly  2364 AG--DTAELTINILDINDNRPTFLDSPYLARVMENTVPPNGGYVLTVNAYDADTPPLNSQVRYFL 2426
            .|  ..||:.:.|.|:||:.|.|.::.     :|.|:..  |..:.:.|.|.|....|:.:.|.:
Zfish   560 EGKYSLAEVFVTITDLNDHPPAFNENS-----LEQTMVI--GAPVKIEAIDEDAEEPNNLIEYSI 617

  Fly  2427 KEGDSD-LFRINASSGDIAL---LKPLD------REQQSEYTLTLVAMDTGSPPLTGTGIVRVEV 2481
            .:.|.| :|.|||.:|:|.|   :|.:|      .::...:::.:.|.|.|||..:.|.:|::
Zfish   618 MKADPDNIFDINADTGEIKLKPYIKSMDIVQNITNQRDCTWSVVVQAKDRGSPSFSTTTVVKI-- 680

  Fly  2482 QDINDNDPV-FELQSYHATVREN------------------------------------LPSGTH 2509
             ||.:..|: ..|.|:....|||                                    |||...
Zfish   681 -DITEATPLKGPLTSFFMNSRENPMHFLGLISGVILILVFVTVIISTVIFVRRNKANRILPSRRI 744

  Fly  2510 VLTPRATDKDEGLNAKLRFNLLGEHMHRFHIDSETGEISTATTLDREETSVYHLTLMAQDSSITE 2574
            :...|...|.:......                            |||..:
Zfish   745 IRKKRKPQKQDDFQEPF----------------------------REEQEI-------------- 767

  Fly  2575 PRASSVNLTISVSDVNDNIPKF--DSTTYNVAVPERISKGEFVFGARALDLDDGENAVVHYTISG 2637
            |||.:||...::...:...|..  ::......:|.....||                 ..:|:.
Zfish   768 PRADNVNFNNNIKVCSHRTPPSPPNAPVMPPPLPSHCRHGE-----------------REWTVP- 814

  Fly  2638 RDQHYFDINTKTGVVSTKLELKTKTKSH---DDLTYTIVISAM 2677
                         .||..:..|:|.|||   |:...|.::|.:
Zfish   815 -------------TVSASVASKSKKKSHRCKDNPVNTALVSEL 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ft	NP_477497.1	Cadherin_repeat	71..152	CDD:206637
		Cadherin_repeat	163..266	CDD:206637
		Cadherin_repeat	275..378	CDD:206637
		Cadherin_repeat	393..490	CDD:206637
		Cadherin_repeat	498..594	CDD:206637
		Cadherin_repeat	603..704	CDD:206637
		Cadherin_repeat	735..814	CDD:206637
		Cadherin	843..>907	CDD:278457
		Cadherin	950..1026	CDD:278457
		Cadherin_repeat	1053..1149	CDD:206637
		Cadherin_repeat	1157..1274	CDD:206637
		Cadherin_repeat	1282..1380	CDD:206637
		Cadherin_repeat	1390..1485	CDD:206637
		Cadherin_repeat	1497..1597	CDD:206637
		Cadherin_repeat	1621..1699	CDD:206637
		Cadherin_repeat	1720..1818	CDD:206637	0/1 (0%)
		Cadherin_repeat	1827..1918	CDD:206637	25/93 (27%)
		Cadherin_repeat	1926..2023	CDD:206637	28/104 (27%)
		Cadherin_repeat	2031..2162	CDD:206637	31/131 (24%)
		Cadherin_repeat	2172..2274	CDD:206637	24/110 (22%)
		Cadherin_repeat	2282..2380	CDD:206637	35/101 (35%)
		Cadherin_repeat	2388..2487	CDD:206637	28/108 (26%)
		Cadherin_repeat	2495..2592	CDD:206637	17/132 (13%)
		Cadherin_repeat	2600..2694	CDD:206637	14/81 (17%)
		Cadherin_repeat	2710..2806	CDD:206637
		Cadherin_repeat	2814..2909	CDD:206637
		Cadherin_repeat	2917..3009	CDD:206637
		Cadherin	3018..3114	CDD:278457
		Cadherin	3129..3220	CDD:278457
		Cadherin_repeat	3233..3330	CDD:206637
		Cadherin_repeat	3338..3434	CDD:206637
		Cadherin_repeat	3443..3541	CDD:206637
		Cadherin_repeat	3550..3647	CDD:206637
		Cadherin_repeat	3657..3753	CDD:206637
		EGF	4017..4047	CDD:278437
		EGF_CA	4056..4090	CDD:238011
		EGF_CA	4094..4128	CDD:238011
		Laminin_G_1	4156..4306	CDD:278483
		LamG	4428..4543	CDD:238058
cdhr1a	NP_001005402.1	Cadherin_repeat	46..134	CDD:206637	24/89 (27%)
		Cadherin_repeat	146..247	CDD:206637	28/100 (28%)
		Cadherin_repeat	256..355	CDD:206637	32/132 (24%)
		Cadherin_repeat	368..474	CDD:206637	24/112 (21%)
		Cadherin_repeat	483..578	CDD:206637	35/100 (35%)
		Cadherin_repeat	584..683	CDD:206637	27/108 (25%)
		OSTbeta	<714..>754	CDD:291707	4/39 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	746..765		4/46 (9%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000