DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ft and CDHR4

DIOPT Version :9

Sequence 1:	NP_477497.1	Gene:	ft / 33627	FlyBaseID:	FBgn0001075	Length:	5147	Species:	Drosophila melanogaster
Sequence 2:	XP_016861855.1	Gene:	CDHR4 / 389118	HGNCID:	34527	Length:	841	Species:	Homo sapiens

Alignment Length:	787	Identity:	175/787 - (22%)
Similarity:	274/787 - (34%)	Gaps:	230/787 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   780 PASMHWKPHY--KLLVSARDAGQRRSQQDAIVEIVLKSKLEMLECG-QAQAGGYEFQMVED--HE 839
            |:...|:..|  ||.:|:      .:|.||::....|.:|: ..|| ....|.....:..|  |.
Human   120 PSLARWQGTYVGKLTLSS------SAQLDALMVNHYKVQLK-FTCGNHVMEGSLSVDVQRDLSHI 177

  Fly   840 QQRNSQPNREVGIVQVKST------------NGKANSHIEYDIIQGDRAQN-------FRIDTRS 885
            |......:....::||..|            .|......:..||.   ||:       |.|:.:.
Human   178 QCAGQFASPAGEMIQVPETVTPGARLYTLLLPGLELHGAQMSIIS---AQDLPHFPGPFSINEQG 239

  Fly   886 GRITTARPLDREEQANYRLTILASSSSSSSAAASSVSYGQ---C--IVNIAIIDLNDNAPVFALD 945
            .....::.|..:.|..::|.|             |||:||   |  :|.:.::.:..:...|.
Human   240 WLQAPSQGLLGQAQKVFQLQI-------------SVSFGQRQSCQGMVIVKVLPVPSSQVSFL-- 289

  Fly   946 RESEPTISLPENAAVGQEIYLSRVRDRDAGVNSRISYSLTNNPNQQFRIGPVTGVLYLQRPI--- 1007
             |....|::|||.|.|.|:...:.|    ||:.|... |:..|:..|.||...||:....|:
Human   290 -EQAQNITIPENLAPGSEVVQVQAR----GVDLRYEI-LSPVPSPLFSIGRADGVVRTTTPLELA 348

  Fly  1008 RAEPGSLIHVELMATDAGSPPLSSKLSLSVLIADVNDHTPVFDHTSYETSLPETTKVNTRFFALA 1072
            |....::..:::.|.:.|....|:||:|::.:..||...|        ..||
Human   349 RTSGTAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNLWPP--------RCLP------------- 392

  Fly  1073 ATDIDLGDNGRISYEIIEGNTERMFGVFPDGYLFVRAPLDREERDYYALTVSCRDAGQPSRSSVV 1137
                                                           ||.||
Human   393 -----------------------------------------------ALLVS------------- 397

  Fly  1138 PVVIHVIDENDNAPQFTNSTFTFSIPENAPADTFVGKLTAVDRD-IGRNAELSFTLSSQTQDFTI 1201
                                   .|||.||..|.:..||..|.| :|.               |:
Human   398 -----------------------QIPETAPVGTVLNTLTCEDPDSVGA---------------TL 424

  Fly  1202 DTRNGFIKTLRP-----FDREALVKVSRNAEASGEDGSLRGSMAGNYMLLEATVSDNGIPRLQDK 1261
            |.:..|..:..|     :||...|..:.:.:..|.......|:         .|.|.|.|::..:
Human   425 DYKLWFRSSSNPASLCLYDRVLEVNATLDCDTPGACFQHAASI---------LVLDGGQPQMTTE 480

  Fly  1262 VKVKVIVTDVNDNAPEFLRAPYHVTISEGASEGTHITHVFTQDADEGLNGDVYYSLAKGNEAGQF 1326
            |.|.|:||.:|:.:|..  ||....:.|.|:..|.:..|...|.|...:...||:  .|... .|
Human   481 VPVLVMVTPINEFSPAC--APRTFRVQEDAAPHTLLGSVVGTDMDYPHDNIEYYT--SGGPT-TF 540

  Fly  1327 NLDSATGQLSLGRRLDRESQEIHHLIVV----AKDAALKHPLSSNASITIVVLDENDNAPEFTQS 1387
            .:|..:|::.|...||.|.|.::.|.|:    .:|....|.||.:.:|||.|.|.||:|||....
Human   541 AVDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPECEPP 605

  Fly  1388 SSEVSVLETSPTGTELMRFRASDADQGVNSQVVFSISAGNRRDTF--------HIDSITGSLYLH 1444
            ..|:::........|:.:.......:.......:||..||.::.|        |.|.:.|..:..
Human   606 FQELTIYAPLGRSVEVTKMSCQIPQEPQRLIYSYSIVGGNSQNRFILQGAILVHSDLVLGPFWPE 670

  Fly  1445 KPLDYEDITSYTLNITASDCG--TPSLSTTVLYNVLVVDDNDNPPIFPSTAIVRQIKEGIP-LKT 1506
            :|..||      |.|..:|.|  ||.||||....|.:|      |...||......:..:| ..|
Human   671 QPRTYE------LLICVADAGPSTPHLSTTATIIVHLV------PRRASTVATSTHRTTVPSTMT 723

  Fly  1507 P-IVTVT 1512
            | :||.|
Human   724 PMLVTDT 730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ft	NP_477497.1	Cadherin_repeat	71..152	CDD:206637
		Cadherin_repeat	163..266	CDD:206637
		Cadherin_repeat	275..378	CDD:206637
		Cadherin_repeat	393..490	CDD:206637
		Cadherin_repeat	498..594	CDD:206637
		Cadherin_repeat	603..704	CDD:206637
		Cadherin_repeat	735..814	CDD:206637	9/35 (26%)
		Cadherin	843..>907	CDD:278457	13/82 (16%)
		Cadherin	950..1026	CDD:278457	21/78 (27%)
		Cadherin_repeat	1053..1149	CDD:206637	6/95 (6%)
		Cadherin_repeat	1157..1274	CDD:206637	30/122 (25%)
		Cadherin_repeat	1282..1380	CDD:206637	30/101 (30%)
		Cadherin_repeat	1390..1485	CDD:206637	25/104 (24%)
		Cadherin_repeat	1497..1597	CDD:206637	6/18 (33%)
		Cadherin_repeat	1621..1699	CDD:206637
		Cadherin_repeat	1720..1818	CDD:206637
		Cadherin_repeat	1827..1918	CDD:206637
		Cadherin_repeat	1926..2023	CDD:206637
		Cadherin_repeat	2031..2162	CDD:206637
		Cadherin_repeat	2172..2274	CDD:206637
		Cadherin_repeat	2282..2380	CDD:206637
		Cadherin_repeat	2388..2487	CDD:206637
		Cadherin_repeat	2495..2592	CDD:206637
		Cadherin_repeat	2600..2694	CDD:206637
		Cadherin_repeat	2710..2806	CDD:206637
		Cadherin_repeat	2814..2909	CDD:206637
		Cadherin_repeat	2917..3009	CDD:206637
		Cadherin	3018..3114	CDD:278457
		Cadherin	3129..3220	CDD:278457
		Cadherin_repeat	3233..3330	CDD:206637
		Cadherin_repeat	3338..3434	CDD:206637
		Cadherin_repeat	3443..3541	CDD:206637
		Cadherin_repeat	3550..3647	CDD:206637
		Cadherin_repeat	3657..3753	CDD:206637
		EGF	4017..4047	CDD:278437
		EGF_CA	4056..4090	CDD:238011
		EGF_CA	4094..4128	CDD:238011
		Laminin_G_1	4156..4306	CDD:278483
		LamG	4428..4543	CDD:238058
CDHR4	XP_016861855.1	Cadherin_repeat	294..384	CDD:206637	26/94 (28%)
		Cadherin_repeat	398..492	CDD:206637	29/117 (25%)
		Cadherin_repeat	499..598	CDD:206637	30/101 (30%)
		Cadherin_repeat	<638..702	CDD:206637	22/69 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1219
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810